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A6M268

- SYL_CLOB8

UniProt

A6M268 - SYL_CLOB8

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Protein
Leucine--tRNA ligase
Gene
leuS, Cbei_4590
Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBEI290402:GHL5-4692-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Cbei_4590
OrganismiClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Taxonomic identifieri290402 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000565: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 816816Leucine--tRNA ligaseUniRule annotation
PRO_1000074828Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290402.Cbei_4590.

Structurei

3D structure databases

ProteinModelPortaliA6M268.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A6M268-1 [UniParc]FASTAAdd to Basket

« Hide

MANYGTKIDE KWQKFWDENE VYKFNPENSG KKLYTLEMFS YPSGAQLHAG    50
HWFNYGPTDS WARLKRMQGY NVFQPMGFDA FGLPAENYAI KTGIHPQDST 100
LKNIETMEKQ LKSMGAMFNW ENEVVTCLPD YYKWTQWLFL KLYEKGLAYR 150
KKAPVNWCPS CNTVLANEQV VDGVCERCST EVTKKDLTQW FFKITEYGDE 200
LLDKLDGLDW PEKTKSMQKH WIGRSYGAEV TFKVKDSDLK FDVFTTRVDT 250
LNGVTYVVLA PENKLVDELT IPEYKAAVEE YKEAAAKQSE IERQSVSKEK 300
TGVFTGSYAI NPINGKVVPI WISDYVLATY GTGCVMAVPA HDERDFAFAT 350
KFNLPIERVI TDKENTNPDL PYCEYGVLVN SGKFDGLTTD EAKKKIVEEL 400
EKDELGAMKK NFRLRDWLVS RQRYWGAPIP VIYCDDCGIV PVPEKDLPVK 450
LPYNVEFTPD GKSPLGKCED FVNTTCPHCG KPAKREADTL DTFVCSSFYY 500
LRYVDNKNDD APFDSEKVNK MLPVDKYVGG PEHACMHLLY ARFITKALRD 550
MGYLNFDEPF LSLTHQGLIL GPDGLKMSKS KGNTISPDDY IKEYGADVFR 600
MYLMFGFGYT EGGAWSDDGI KSVGKFVDRI ERILENCRNI INSNESTKDS 650
IDSAEKELNF WKHNTIKGVT EDGDKMQFNT AIARLMELTN ALNKYTQENI 700
KNANFLKETI VDFIKLLAPF APHFAEEQWS LLGNNSTIFN EKWPEFNPAA 750
LVKDEVEIAI QINGKIKAKI MVASNLDEEG IKAASLENET IKENTEGKTI 800
VKVIVIKGRL VNIVVK 816
Length:816
Mass (Da):92,942
Last modified:July 24, 2007 - v1
Checksum:iF6D655DD20488AA7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000721 Genomic DNA. Translation: ABR36698.1.
RefSeqiYP_001311654.1. NC_009617.1.

Genome annotation databases

EnsemblBacteriaiABR36698; ABR36698; Cbei_4590.
GeneIDi5295744.
KEGGicbe:Cbei_4590.
PATRICi19353506. VBICloBei69853_4768.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000721 Genomic DNA. Translation: ABR36698.1 .
RefSeqi YP_001311654.1. NC_009617.1.

3D structure databases

ProteinModelPortali A6M268.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290402.Cbei_4590.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR36698 ; ABR36698 ; Cbei_4590 .
GeneIDi 5295744.
KEGGi cbe:Cbei_4590.
PATRICi 19353506. VBICloBei69853_4768.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CBEI290402:GHL5-4692-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51743 / NCIMB 8052.

Entry informationi

Entry nameiSYL_CLOB8
AccessioniPrimary (citable) accession number: A6M268
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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