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A6M229 (IOLC_CLOB8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-dehydro-2-deoxygluconokinase
EC=2.7.1.92
Alternative name(s):
2-deoxy-5-keto-D-gluconate kinase
Short name=DKG kinase
Gene names
Name:iolC
Ordered Locus Names:Cbei_4550
OrganismClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) [Complete proteome] [HAMAP]
Taxonomic identifier290402 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium ›

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the phosphorylation of 5-dehydro-2-deoxy-D-gluconate (2-deoxy-5-keto-D-gluconate or DKG) to 6-phospho-5-dehydro-2-deoxy-D-gluconate (DKGP) By similarity. HAMAP-Rule MF_01668

Catalytic activity

ATP + 5-dehydro-2-deoxy-D-gluconate = ADP + 6-phospho-5-dehydro-2-deoxy-D-gluconate. HAMAP-Rule MF_01668

Pathway

Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 5/7. HAMAP-Rule MF_01668

Sequence similarities

Belongs to the carbohydrate kinase PfkB family.

Ontologies

Keywords
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processinositol catabolic process

Inferred from electronic annotation. Source: HAMAP

   Molecular_function5-dehydro-2-deoxygluconokinase activity

Inferred from electronic annotation. Source: HAMAP

ATP binding

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3393395-dehydro-2-deoxygluconokinase HAMAP-Rule MF_01668
PRO_0000352293

Sequences

Sequence LengthMass (Da)Tools
A6M229 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 3340463172C91E71

FASTA33937,652
        10         20         30         40         50         60 
MEYIKFDKAR KMDIVPIGRV AIDFNPIDIN KPLSESSTFK KYLGGSPANI AVGLARLGKK 

        70         80         90        100        110        120 
IGFIGKVSKD QFGEFVVNYF DNEGIDTSQI KYSKNGENLG LTFTEIASPT ESSILMYRQG 

       130        140        150        160        170        180 
IADLELNVDE IDEEYIKNTK AIVISGTALA KSPSREAALK ALELAKRNNT VVIFDVDYRA 

       190        200        210        220        230        240 
YNWKNSDEIA IYYSIAGKQS DIIMGSREEF DLMEKLITRE KNSDEETAKR WLDYGNKIVV 

       250        260        270        280        290        300 
IKHGKEGSTA YTSDGKSYNI KPFPVKLLKS FGGGDAYASA FLYGLLEGWS IIDSLEFGSA 

       310        320        330 
SAAMLVASHS CSQDMPTVEA IRNFIKEEKE EYGDMVARA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000721 Genomic DNA. Translation: ABR36659.1.
RefSeqYP_001311615.1. NC_009617.1.

3D structure databases

ProteinModelPortalA6M229.
ModBaseSearch...

Protein-protein interaction databases

STRING290402.Cbei_4550.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR36659; ABR36659; Cbei_4550.
GeneID5295705.
KEGGcbe:Cbei_4550.
PATRIC19353422. VBICloBei69853_4726.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0524.
HOGENOMHOG000235951.
KOK03338.
OMAANEINRP.
ProtClustDBCLSK873289.

Enzyme and pathway databases

BioCycCBEI290402:GHL5-4689-MONOMER.
UniPathwayUPA00076; UER00146.

Family and domain databases

HAMAPMF_01668. IolC.
InterProIPR002173. Carboh/pur_kinase_PfkB_CS.
IPR022841. DKG_kinase.
IPR011611. PfkB_dom.
[Graphical view]
PfamPF00294. PfkB. 1 hit.
[Graphical view]
PROSITEPS00583. PFKB_KINASES_1. False negative.
PS00584. PFKB_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOLC_CLOB8
AccessionPrimary (citable) accession number: A6M229
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: July 24, 2007
Last modified: May 1, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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