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A6M1W7 (THIM_CLOB8) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:Cbei_4488
OrganismClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) [Complete proteome] [HAMAP]
Taxonomic identifier290402 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000383837

Sites

Binding site481Substrate; via amide nitrogen By similarity
Binding site1241ATP By similarity
Binding site1751ATP By similarity
Binding site2021Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
A6M1W7 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: CFDCDCEA9B1E2A87

FASTA27628,904
        10         20         30         40         50         60 
MSNEISIKIG SLLNEVRNKK PLVHNITNYV TVNDCANILL AIGASPIMAD DIKEAADITK 

        70         80         90        100        110        120 
ISSALVINIG TLNERTIESM IASGKKANEL NIPVVFDPVG AGASEFRNST TKRLLEEVKI 

       130        140        150        160        170        180 
SVLRGNMSEI KFISGLGSTT KGVDASENDA RTGNDEGIDV AKNLAKKLQC TVAITGATDI 

       190        200        210        220        230        240 
ISDGERVVIL ENGTKMLSNV TGTGCMTTAL IGAFCGAGSD YFIGAVSGII SMGISGEIAL 

       250        260        270 
DKAGKIGTGS FHIAIIDAIS NLTSNIIEKM NKIKEI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000721 Genomic DNA. Translation: ABR36597.1.
RefSeqYP_001311553.1. NC_009617.1.

3D structure databases

ProteinModelPortalA6M1W7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290402.Cbei_4488.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR36597; ABR36597; Cbei_4488.
GeneID5295643.
KEGGcbe:Cbei_4488.
PATRIC19353292. VBICloBei69853_4661.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMATISESTY.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycCBEI290402:GHL5-4590-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_CLOB8
AccessionPrimary (citable) accession number: A6M1W7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 24, 2007
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways