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A6M129 (A6M129_CLOB8) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length402 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR000108-3 PIRNR PIRNR000108

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding307 – 3126NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2581NADP By similarity PIRSR PIRSR000108-4
Binding site3251NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
A6M129 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 047EC017DE1C8D6F

FASTA40245,692
        10         20         30         40         50         60 
MEKIKMSTPL VEMDGDEMTR IIWGAIKEEL LNPFIELNTE YYDLGLEYRN ETDDQVTVDA 

        70         80         90        100        110        120 
AEAIKKYKVG VKCATITPNA ARVKEYNLKE MWKSPNGTIR AILDGTVFRA PIIVEPVKPY 

       130        140        150        160        170        180 
VRTWKKPITI ARHAYGDVYR DVEMKIEGKG KCELVFTSET GEEKRELVHN FAGDGVVLGM 

       190        200        210        220        230        240 
HNLNKSIESF ARACFNFALD TKQDLWFATK DTISKKYDHT FKDIFQDIFD DEYKIKFDEA 

       250        260        270        280        290        300 
GIEYFYTLID DVVARVVKSE GGIIWACKNY DGDVMSDMVA TAFGSLAMMT SVLVSPEGNY 

       310        320        330        340        350        360 
EYEAAHGTVQ RHYYKHLQGE ETSTNSIATI FAWSGALKKR GELDNNADLV NFADKLEKAS 

       370        380        390        400 
IKTIEDGIMT KDLSLLAEHD NIQTLNTFDF IKAIRKTLEE IL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000721 Genomic DNA. Translation: ABR36309.1.
RefSeqYP_001311265.1. NC_009617.1.

3D structure databases

ProteinModelPortalA6M129.
SMRA6M129. Positions 3-401.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290402.Cbei_4199.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR36309; ABR36309; Cbei_4199.
GeneID5295355.
KEGGcbe:Cbei_4199.
PATRIC19352690. VBICloBei69853_4360.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.
OrthoDBEOG628F3X.
ProtClustDBPRK08299.

Enzyme and pathway databases

BioCycCBEI290402:GHL5-4301-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA6M129_CLOB8
AccessionPrimary (citable) accession number: A6M129
Entry history
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)