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A6M129

- A6M129_CLOB8

UniProt

A6M129 - A6M129_CLOB8

Protein

Isocitrate dehydrogenase [NADP]

Gene

Cbei_4199

Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771SubstrateUniRule annotation
    Binding sitei82 – 821NADP
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei210 – 2101Critical for catalysisUniRule annotation
    Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
    Binding sitei258 – 2581NADP
    Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation
    Binding sitei325 – 3251NADP; via amide nitrogen and carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADP
    Nucleotide bindingi307 – 3126NADP

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciCBEI290402:GHL5-4301-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:Cbei_4199Imported
    OrganismiClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)Imported
    Taxonomic identifieri290402 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000565: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi290402.Cbei_4199.

    Structurei

    3D structure databases

    ProteinModelPortaliA6M129.
    SMRiA6M129. Positions 3-401.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000019858.
    KOiK00031.
    OMAiCVNTVET.
    OrthoDBiEOG628F3X.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6M129-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKIKMSTPL VEMDGDEMTR IIWGAIKEEL LNPFIELNTE YYDLGLEYRN    50
    ETDDQVTVDA AEAIKKYKVG VKCATITPNA ARVKEYNLKE MWKSPNGTIR 100
    AILDGTVFRA PIIVEPVKPY VRTWKKPITI ARHAYGDVYR DVEMKIEGKG 150
    KCELVFTSET GEEKRELVHN FAGDGVVLGM HNLNKSIESF ARACFNFALD 200
    TKQDLWFATK DTISKKYDHT FKDIFQDIFD DEYKIKFDEA GIEYFYTLID 250
    DVVARVVKSE GGIIWACKNY DGDVMSDMVA TAFGSLAMMT SVLVSPEGNY 300
    EYEAAHGTVQ RHYYKHLQGE ETSTNSIATI FAWSGALKKR GELDNNADLV 350
    NFADKLEKAS IKTIEDGIMT KDLSLLAEHD NIQTLNTFDF IKAIRKTLEE 400
    IL 402
    Length:402
    Mass (Da):45,692
    Last modified:July 24, 2007 - v1
    Checksum:i047EC017DE1C8D6F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000721 Genomic DNA. Translation: ABR36309.1.
    RefSeqiWP_012060356.1. NC_009617.1.
    YP_001311265.1. NC_009617.1.

    Genome annotation databases

    EnsemblBacteriaiABR36309; ABR36309; Cbei_4199.
    GeneIDi5295355.
    KEGGicbe:Cbei_4199.
    PATRICi19352690. VBICloBei69853_4360.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000721 Genomic DNA. Translation: ABR36309.1 .
    RefSeqi WP_012060356.1. NC_009617.1.
    YP_001311265.1. NC_009617.1.

    3D structure databases

    ProteinModelPortali A6M129.
    SMRi A6M129. Positions 3-401.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290402.Cbei_4199.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR36309 ; ABR36309 ; Cbei_4199 .
    GeneIDi 5295355.
    KEGGi cbe:Cbei_4199.
    PATRICi 19352690. VBICloBei69853_4360.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000019858.
    KOi K00031.
    OMAi CVNTVET.
    OrthoDBi EOG628F3X.

    Enzyme and pathway databases

    BioCyci CBEI290402:GHL5-4301-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51743 / NCIMB 8052Imported.

    Entry informationi

    Entry nameiA6M129_CLOB8
    AccessioniPrimary (citable) accession number: A6M129
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 24, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3