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A6LXU8 (ALF1_CLOB8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase class 1

EC=4.1.2.13
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name=FBP aldolase
Gene names
Name:fda
Ordered Locus Names:Cbei_3039
OrganismClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) [Complete proteome] [HAMAP]
Taxonomic identifier290402 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. HAMAP-Rule MF_00729

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. HAMAP-Rule MF_00729

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Fructose-bisphosphate aldolase class 1 HAMAP-Rule MF_00729
PRO_1000083323

Sites

Active site1761Proton acceptor By similarity
Active site2131Schiff-base intermediate with dihydroxyacetone-P By similarity

Sequences

Sequence LengthMass (Da)Tools
A6LXU8 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 5576E1369D51F0EE

FASTA29533,349
        10         20         30         40         50         60 
MNENQMKRIH TGKGFIAALD QSGGSTPKAL LEYGIKENSY SNEDEMFGLV HEMRKRIIKS 

        70         80         90        100        110        120 
PAFTLEYILG AILFEDTMYR TIDNQYTPDY LWKEKNIVPF LKVDKGLTEI ENGVQLMKPI 

       130        140        150        160        170        180 
SNLDDLLKHA VEKNIFGTKM RSVIKEANAK GIKMLVNQQF EIGKQIVEAG LVPIIEPEVD 

       190        200        210        220        230        240 
IHSTDKEESE KLLKLEILEQ LSKLDKETKV MLKLSIPTQD NFYIDLIDDP HVVRVVALSG 

       250        260        270        280        290 
GYSQAEAKER LGRNHGLIAS FSRALSQGLT AQQTEEEFNG TISKSIKEIY EASIK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000721 Genomic DNA. Translation: ABR35178.1.
RefSeqYP_001310134.1. NC_009617.1.

3D structure databases

ProteinModelPortalA6LXU8.
SMRA6LXU8. Positions 1-295.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290402.Cbei_3039.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR35178; ABR35178; Cbei_3039.
GeneID5294224.
KEGGcbe:Cbei_3039.
PATRIC19350262. VBICloBei69853_3154.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3588.
HOGENOMHOG000073502.
KOK01623.
OMAGTKMRSV.
OrthoDBEOG6M6JJT.
ProtClustDBPRK05377.

Enzyme and pathway databases

BioCycCBEI290402:GHL5-3133-MONOMER.
UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00729. FBP_aldolase_1.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
IPR023014. FBP_aldolase_I_bac.
[Graphical view]
PfamPF00274. Glycolytic. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALF1_CLOB8
AccessionPrimary (citable) accession number: A6LXU8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways