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Protein

Fructose-bisphosphate aldolase class 1

Gene

fda

Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei176 – 1761Proton acceptorUniRule annotation
Active sitei213 – 2131Schiff-base intermediate with dihydroxyacetone-PUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

BioCyciCBEI290402:GHL5-3133-MONOMER.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase class 1UniRule annotation (EC:4.1.2.13UniRule annotation)
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name:
FBP aldolaseUniRule annotation
Gene namesi
Name:fdaUniRule annotation
Ordered Locus Names:Cbei_3039
OrganismiClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Taxonomic identifieri290402 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000565 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Fructose-bisphosphate aldolase class 1PRO_1000083323Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290402.Cbei_3039.

Structurei

3D structure databases

ProteinModelPortaliA6LXU8.
SMRiA6LXU8. Positions 1-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I fructose-bisphosphate aldolase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3588.
HOGENOMiHOG000073502.
KOiK01623.
OMAiEPEVDIH.
OrthoDBiEOG6M6JJT.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00729. FBP_aldolase_1.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
IPR023014. FBA_I_Gram+-type.
[Graphical view]
PfamiPF00274. Glycolytic. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6LXU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNENQMKRIH TGKGFIAALD QSGGSTPKAL LEYGIKENSY SNEDEMFGLV
60 70 80 90 100
HEMRKRIIKS PAFTLEYILG AILFEDTMYR TIDNQYTPDY LWKEKNIVPF
110 120 130 140 150
LKVDKGLTEI ENGVQLMKPI SNLDDLLKHA VEKNIFGTKM RSVIKEANAK
160 170 180 190 200
GIKMLVNQQF EIGKQIVEAG LVPIIEPEVD IHSTDKEESE KLLKLEILEQ
210 220 230 240 250
LSKLDKETKV MLKLSIPTQD NFYIDLIDDP HVVRVVALSG GYSQAEAKER
260 270 280 290
LGRNHGLIAS FSRALSQGLT AQQTEEEFNG TISKSIKEIY EASIK
Length:295
Mass (Da):33,349
Last modified:July 24, 2007 - v1
Checksum:i5576E1369D51F0EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000721 Genomic DNA. Translation: ABR35178.1.
RefSeqiWP_012059231.1. NC_009617.1.
YP_001310134.1. NC_009617.1.

Genome annotation databases

EnsemblBacteriaiABR35178; ABR35178; Cbei_3039.
KEGGicbe:Cbei_3039.
PATRICi19350262. VBICloBei69853_3154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000721 Genomic DNA. Translation: ABR35178.1.
RefSeqiWP_012059231.1. NC_009617.1.
YP_001310134.1. NC_009617.1.

3D structure databases

ProteinModelPortaliA6LXU8.
SMRiA6LXU8. Positions 1-295.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi290402.Cbei_3039.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR35178; ABR35178; Cbei_3039.
KEGGicbe:Cbei_3039.
PATRICi19350262. VBICloBei69853_3154.

Phylogenomic databases

eggNOGiCOG3588.
HOGENOMiHOG000073502.
KOiK01623.
OMAiEPEVDIH.
OrthoDBiEOG6M6JJT.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.
BioCyciCBEI290402:GHL5-3133-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00729. FBP_aldolase_1.
InterProiIPR013785. Aldolase_TIM.
IPR000741. FBA_I.
IPR023014. FBA_I_Gram+-type.
[Graphical view]
PfamiPF00274. Glycolytic. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51743 / NCIMB 8052.

Entry informationi

Entry nameiALF1_CLOB8
AccessioniPrimary (citable) accession number: A6LXU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: May 27, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.