Reviewed, UniProtKB/Swiss-Prot A6LWG6 (GCH1_CLOB8)

Names and origin

Protein names

Recommended name:
    GTP cyclohydrolase 1
    EC=3.5.4.16
Alternative name(s):
    GTP cyclohydrolase I
      Short name=GTP-CH-I

Gene names

Name:	folE
Ordered Locus Names:	Cbei_2540

Organism

Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) [Complete proteome] [HAMAP]

Taxonomic identifier

290402 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223
Subunit structure	Homopolymer By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	GTP cyclohydrolase 1 HAMAP MF_00223		PRO_1000100166
Sites
	Metal binding	88	1	Zinc By similarity
	Metal binding	91	1	Zinc By similarity
	Metal binding	160	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6LWG6-1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: B97C129FDB7D62E7	FASTA	197	22,225
	10 20 30 40 50 60 MPKKIDTKKI EECIREIIVA LGDDPNREGL LDTPKRVSKM YEEVFQGMTL SNREIAEAFG 70 80 90 100 110 120 TTFENEDYDS ETHNNMVVVK DIPIHSYCEH HLALMYNMKV TVVYIPKDKI IGLSKISRIA 130 140 150 160 170 180 DMVGRRLQLQ ERIGTDIAEI VSMVTKSSDV GVLITGEHGC MTSRGIKKPG TLTTTTTFTG 190 KFQTNDLLRQ EALLIMK

References

[1]

"Complete sequence of Clostridium beijerinckii NCIMB 8052." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Tapia R., Brainard J., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Mikhailova N., Bennet G., Cann I., Chen J.-S., Contreras A.L., Jones D., Kashket E., Mitchell W., Stoddard S., Schwarz W., Qureshi N., Young M., Shi Z., Ezeji T., White B., Blaschek H., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000721 Genomic DNA. Translation: ABR34696.1.
RefSeq	YP_001309652.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6LWG6.
Genome annotation databases
GeneID	5293741.
GenomeReviews	Gene locus Cbei_2540 in contig CP000721_GR.
KEGG	cbe:Cbei_2540.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	ARIVEMF.
Family and domain databases
HAMAP	MF_00223. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
ProDom	PD003330. GTP_cyclohydroI. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00063. folE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH1_CLOB8

Accession

Primary (citable) accession number: A6LWG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	July 24, 2007
Last modified:	November 3, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)