A6LUH4 (A6LUH4_CLOB8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Altronate oxidoreductase 1 HAMAP MF_00670
EC=1.1.1.58 HAMAP MF_00670

Alternative name(s):
Tagaturonate dehydrogenase 1 HAMAP MF_00670
Tagaturonate reductase 1 HAMAP MF_00670

Gene names

Name:	uxaB1 HAMAP MF_00670
Ordered Locus Names:	Cbei_1833

Organism

Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) [Complete proteome] [HAMAP] EMBL ABR34004.1

Taxonomic identifier

290402 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	482 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-altronate + NAD+ = D-tagaturonate + NADH. HAMAP MF_00670
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00670
Sequence similarities	Belongs to the mannitol dehydrogenase family. UxaB subfamily. HAMAP MF_00670

Ontologies

Keywords
Ligand	NAD HAMAP MF_00670
Molecular function	Oxidoreductase HAMAP MF_00670
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro tagaturonate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	18 – 29	12	NAD By similarity HAMAP MF_00670

Sequences

	Sequence		Length	Mass (Da)
	A6LUH4 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 97A50B8F4513A91A	FASTA	482	55,169
	10 20 30 40 50 60 MKLNKKLYKE FKTYPEKVLQ FGEGNFLRAF VDWQIDKMND EADFNGSVVV VQPLENGLVD 70 80 90 100 110 120 MLNDQDCLYT LYLQGVQNGQ ASKTHKVINS ISRGINPYRD YNEYLKVAEN PDLRFIVSNT 130 140 150 160 170 180 TEAGIAFDEN DTLNGGCQKS YPGKLTAFLY HRFNAFNGDD SKGFIIIPCE LIDRNGEKLK 190 200 210 220 230 240 EIVLKYAEVW NLGQDFIDWI NNANTFCCSL VDRIVPGYPR DTIDEVREEL GYDDNLVDVG 250 260 270 280 290 300 EIFHLWVIEG PQSIKDELPI EKAGLNVKVV DDMTPYRTRK VRILNGPHTA MVPVAYLYGL 310 320 330 340 350 360 ETVGESVDHE VIGKYVHDVI YDEIIETLDL PHEELVEFAD AIIERFQNPY VKHYLMSIAL 370 380 390 400 410 420 NSLSKYKTRD LPSLTEYLKR KGALPKKLVF SLASLIEFYK GKRGEEDIQL ADDEDILELF 430 440 450 460 470 480 KELWGKHDGT KEGLNKIVTS VLAYEKNWGS NLNEIPNLTD EVSRYLEIIE KVGMKDAVKE VL

References

[1]

"Complete sequence of Clostridium beijerinckii NCIMB 8052." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Tapia R., Brainard J., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Mikhailova N., Bennet G., Cann I., Chen J.-S., Contreras A.L., Jones D., Kashket E., Mitchell W., Stoddard S., Schwarz W., Qureshi N., Young M., Shi Z., Ezeji T., White B., Blaschek H., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51743 / NCIMB 8052.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000721 Genomic DNA. Translation: ABR34004.1.
RefSeq	YP_001308960.1. NC_009617.1.
3D structure databases
ProteinModelPortal	A6LUH4.
ModBase	Search...
Protein-protein interaction databases
STRING	A6LUH4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5293048.
GenomeReviews	Gene locus Cbei_1833 in contig CP000721_GR.
KEGG	cbe:Cbei_1833.
PATRIC	19347704. VBICloBei69853_1891.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0246.
HOGENOM	HBG297101.
OMA	CSEVELV.
ProtClustDB	PRK03643.
Family and domain databases
HAMAP	MF_00670. Altron_oxidoreduct. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR023668. Altronate_OxRdtase. IPR013328. DH_multihelical. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00041.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A6LUH4_CLOB8

Accession

Primary (citable) accession number: A6LUH4

Entry history

Integrated into UniProtKB/TrEMBL:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)