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A6LTC5

- SYE_CLOB8

UniProt

A6LTC5 - SYE_CLOB8

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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei296 – 2961ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBEI290402:GHL5-1499-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Cbei_1427
OrganismiClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Taxonomic identifieri290402 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000565: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Glutamate--tRNA ligasePRO_0000367647Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi290402.Cbei_1427.

Structurei

3D structure databases

ProteinModelPortaliA6LTC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5111"HIGH" regionAdd
BLAST
Motifi293 – 2975"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000252720.
KOiK01885.
OMAiDISFPEN.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

A6LTC5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFEKLADII FGNVEHTTEY YVEKYPKRSL KEGARVTRYA PSPTGFQHIG
60 70 80 90 100
GVFAALINER LASQSEGVFY LRIEDTDQKR EVEGAIEDTI ATMHNFGMDF
110 120 130 140 150
SEGMTGEETS KGEYGPYRQS QRAEIYNTFA KDLLIKGLAY PDFCTPEELA
160 170 180 190 200
QLRERQIANK ITPGYYGEYA KFRNITEEEA IKRIENGEKY IIRLKSPGNP
210 220 230 240 250
EKRVEFHDLI KGDISFPENN QDVVLIKGDG LPTYHFAHAI DDYLMRTTDV
260 270 280 290 300
IRGEEWLSSL PIHVQLFEVL GFEAPRYAHI PTIMKQDGGS KRKLSKRKDA
310 320 330 340 350
EAAVSYYKEV GFPVVTVIEY LLNIVNSTYE EWRAENPKAD YHEFEVHLEK
360 370 380 390 400
MGKSGALFDL VKLNDVSKDR IAAMKATDVY EYYTAWAKEF DAEMYKLVTE
410 420 430 440 450
NETMAKEIFN IDKEGPKPRK DFAKWDEVKD KIFYFFDELF YKESAEQIEL
460 470 480 490 500
PKGVTLEAAK EIVETYKKEF KFDVESQEAW FDDLKEIGIR LGYCANRKEF
510 520 530 540 550
KANPDQYKGM ISDVAGAVRA ALTHRTNSPD IYTIMQIIGE ENTRNRFDKF

LNI
Length:553
Mass (Da):63,868
Last modified:July 24, 2007 - v1
Checksum:iA0CF47228E421ED5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000721 Genomic DNA. Translation: ABR33605.1.
RefSeqiYP_001308561.1. NC_009617.1.

Genome annotation databases

EnsemblBacteriaiABR33605; ABR33605; Cbei_1427.
GeneIDi5292649.
KEGGicbe:Cbei_1427.
PATRICi19346844. VBICloBei69853_1468.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000721 Genomic DNA. Translation: ABR33605.1 .
RefSeqi YP_001308561.1. NC_009617.1.

3D structure databases

ProteinModelPortali A6LTC5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290402.Cbei_1427.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR33605 ; ABR33605 ; Cbei_1427 .
GeneIDi 5292649.
KEGGi cbe:Cbei_1427.
PATRICi 19346844. VBICloBei69853_1468.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000252720.
KOi K01885.
OMAi DISFPEN.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci CBEI290402:GHL5-1499-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51743 / NCIMB 8052.

Entry informationi

Entry nameiSYE_CLOB8
AccessioniPrimary (citable) accession number: A6LTC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3