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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei296ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Cbei_1427
OrganismiClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Taxonomic identifieri290402 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000565 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003676471 – 553Glutamate--tRNA ligaseAdd BLAST553

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi290402.Cbei_1427

Structurei

3D structure databases

ProteinModelPortaliA6LTC5
SMRiA6LTC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 51"HIGH" regionUniRule annotationAdd BLAST11
Motifi293 – 297"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252720
KOiK01885
OMAiALTHRTN
OrthoDBiPOG091H021W

Family and domain databases

Gene3Di1.10.10.3501 hit
3.40.50.6201 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit

Sequencei

Sequence statusi: Complete.

A6LTC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFEKLADII FGNVEHTTEY YVEKYPKRSL KEGARVTRYA PSPTGFQHIG
60 70 80 90 100
GVFAALINER LASQSEGVFY LRIEDTDQKR EVEGAIEDTI ATMHNFGMDF
110 120 130 140 150
SEGMTGEETS KGEYGPYRQS QRAEIYNTFA KDLLIKGLAY PDFCTPEELA
160 170 180 190 200
QLRERQIANK ITPGYYGEYA KFRNITEEEA IKRIENGEKY IIRLKSPGNP
210 220 230 240 250
EKRVEFHDLI KGDISFPENN QDVVLIKGDG LPTYHFAHAI DDYLMRTTDV
260 270 280 290 300
IRGEEWLSSL PIHVQLFEVL GFEAPRYAHI PTIMKQDGGS KRKLSKRKDA
310 320 330 340 350
EAAVSYYKEV GFPVVTVIEY LLNIVNSTYE EWRAENPKAD YHEFEVHLEK
360 370 380 390 400
MGKSGALFDL VKLNDVSKDR IAAMKATDVY EYYTAWAKEF DAEMYKLVTE
410 420 430 440 450
NETMAKEIFN IDKEGPKPRK DFAKWDEVKD KIFYFFDELF YKESAEQIEL
460 470 480 490 500
PKGVTLEAAK EIVETYKKEF KFDVESQEAW FDDLKEIGIR LGYCANRKEF
510 520 530 540 550
KANPDQYKGM ISDVAGAVRA ALTHRTNSPD IYTIMQIIGE ENTRNRFDKF

LNI
Length:553
Mass (Da):63,868
Last modified:July 24, 2007 - v1
Checksum:iA0CF47228E421ED5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000721 Genomic DNA Translation: ABR33605.1
RefSeqiWP_011968759.1, NC_009617.1

Genome annotation databases

EnsemblBacteriaiABR33605; ABR33605; Cbei_1427
KEGGicbe:Cbei_1427

Similar proteinsi

Entry informationi

Entry nameiSYE_CLOB8
AccessioniPrimary (citable) accession number: A6LTC5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: July 24, 2007
Last modified: February 28, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome