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A6LSZ4 (KHSE_CLOB8) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39
Gene names
Name:thrB
Ordered Locus Names:Cbei_1294
OrganismClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) [Complete proteome] [HAMAP]
Taxonomic identifier290402 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384

Subcellular location

Cytoplasm Potential HAMAP MF_00384.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

homoserine kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298Homoserine kinase HAMAP MF_00384
PRO_1000080119

Regions

Nucleotide binding83 – 9311ATP Potential

Sequences

Sequence LengthMass (Da)Tools
A6LSZ4 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 234FFAA4EDC53FB6

FASTA29832,929
        10         20         30         40         50         60 
MITVRVPATS ANMGPGFDTL GIALNLYNDF GFREIEDGLK FNGMPEEFCN EDNIIYKAMK 

        70         80         90        100        110        120 
YCFDKAGYKI KGLEISEIKQ DVPVSRGLGS SSTCIVGGLV GANEILGKKF SEEELLEMAV 

       130        140        150        160        170        180 
EIEGHPDNVA PALLGGMVVA IFDENKTYYD KIDVKNGIKF ISIIPNFRLS TEEARKVLPK 

       190        200        210        220        230        240 
EISLKDGVYN VSRAALMVAC FSSGKYELLR YACKDAFHQN YRSKLIPGFE EVYNKSYELG 

       250        260        270        280        290 
ALACYLSGAG PTIMAIIDEK DERFSNKLKE FLQIKGLEWN ILGLSLDNAG ATIIEGTK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000721 Genomic DNA. Translation: ABR33474.1.
RefSeqYP_001308430.1. NC_009617.1.

3D structure databases

ProteinModelPortalA6LSZ4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6LSZ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5292518.
GenomeReviewsGene locus Cbei_1294 in contig CP000721_GR.
KEGGcbe:Cbei_1294.
PATRIC19346564. VBICloBei69853_1328.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0083.
HOGENOMHBG646290.
OMANNALMST.
ProtClustDBPRK01212.

Enzyme and pathway databases

BioCycCBEI290402:CBEI_1294-MONOMER.

Family and domain databases

HAMAPMF_00384. Homoser_kinase.
[Tree]
InterProIPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
Gene3DG3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KOK00872.
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. ThrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKHSE_CLOB8
AccessionPrimary (citable) accession number: A6LSZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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