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A6LSC2 (FABH_CLOB8) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
EC=2.3.1.180
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III
Beta-ketoacyl-ACP synthase III
Short name=KAS III
Gene names
Name:fabH
Ordered Locus Names:Cbei_1068
OrganismClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) [Complete proteome] [HAMAP]
Taxonomic identifier290402 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815

Subunit structure

Homodimer By similarity. HAMAP MF_01815

Subcellular location

Cytoplasm Probable HAMAP MF_01815.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3233233-oxoacyl-[acyl-carrier-protein] synthase 3 HAMAP MF_01815
PRO_1000088306

Regions

Region251 – 2555ACP-binding By similarity

Sites

Active site1121 By similarity
Active site2501 By similarity
Active site2801 By similarity

Sequences

Sequence LengthMass (Da)Tools
A6LSC2 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 07F11C29080E3313

FASTA32335,132
        10         20         30         40         50         60 
MSNIKIAGIG AYLPSLVVTN DRISEFVETS DEWIVQRTGM RERRISEGEN TSDISTKAAK 

        70         80         90        100        110        120 
LALERAGIDA KDLELIIVAT ISPDMFIPSV ACLVQSNLDA SKAACFDISV ACSGFVYGLE 

       130        140        150        160        170        180 
TAKALMMSMN YKNALVVGAE VLSKVTDWTD RSTCILFGDG AGAAVLKRDE APGIIKSYLR 

       190        200        210        220        230        240 
ADGKKGEALT IGATDFDTPF SKEKKLAKRT IDMNGREILR FAVSAIDEAV TEVMKDTNVS 

       250        260        270        280        290        300 
FDDIKYIVPH QANYRIIKLA AEKLKLSEDK FYLNLEKVGN TSAATVPIAL NEMYEKGLLN 

       310        320 
KGDKIILVAF GGGLTYAATL LEW

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000721 Genomic DNA. Translation: ABR33252.1.
RefSeqYP_001308208.1. NC_009617.1.

3D structure databases

ProteinModelPortalA6LSC2.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6LSC2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5292296.
GenomeReviewsGene locus Cbei_1068 in contig CP000721_GR.
KEGGcbe:Cbei_1068.
PATRIC19346096. VBICloBei69853_1094.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0332.
HOGENOMHBG649927.
OMAKEIGAIN.
ProtClustDBCLSK2326990.

Enzyme and pathway databases

BioCycCBEI290402:CBEI_1068-MONOMER.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK00648.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFABH_CLOB8
AccessionPrimary (citable) accession number: A6LSC2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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