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A6LSB3

- PUR9_CLOB8

UniProt

A6LSB3 - PUR9_CLOB8

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Cbei_1059
Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciCBEI290402:GHL5-1131-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Cbei_1059
OrganismiClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Taxonomic identifieri290402 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000565: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000076478Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290402.Cbei_1059.

Structurei

3D structure databases

ProteinModelPortaliA6LSB3.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiMGESEAN.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A6LSB3-1 [UniParc]FASTAAdd to Basket

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MKKRALISVF DKEGVLDFAK FLVSKDVEIV STGGTYKYLK ENGLNVIEIN    50
EVTDFPEMLD GRVKTLHPLV HAGILAIRDN EEHMNTLKGR NIHTIDYVVV 100
NLYPFFEKVK EDLEFEEKVE FIDIGGPTML RAAAKNFQDV VVISDKNDYK 150
VVMEEIEANG ETSYKTKKKL AGKVFNLMSA YDGAISNFLL ADEEEEYPEY 200
LSVSYKKMQS LRYGENSHQT AAVYASTMLD GAMNTFETLN GKELSYNNFK 250
DVDIAWKCAN EFDEPACCAL KHNTPCGVAI GKDSYEAYMK AYEVDPTSIF 300
GGIIGFNRKV DKKTAEEMVK IFLEVIAAPE YDEDALEVLK TKKNLRVLKF 350
HNTPKADKYM VTVDGAMLVQ EEDNKLVEEI KVVTEKKPTD EEMKDLLFGM 400
KVVKYVKSNA IVVAHNGIAL GIGGGQVNRI WPTEDALKRG KGATILASDA 450
YFPFGDVAET AAKAGIKAII QPGGSIRDQE SIDVCNKYGI SMVFTGYRHF 500
KH 502
Length:502
Mass (Da):56,188
Last modified:July 24, 2007 - v1
Checksum:i73FC8E2B42D35974
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000721 Genomic DNA. Translation: ABR33243.1.
RefSeqiWP_011968402.1. NC_009617.1.
YP_001308199.1. NC_009617.1.

Genome annotation databases

EnsemblBacteriaiABR33243; ABR33243; Cbei_1059.
GeneIDi5292287.
KEGGicbe:Cbei_1059.
PATRICi19346078. VBICloBei69853_1085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000721 Genomic DNA. Translation: ABR33243.1 .
RefSeqi WP_011968402.1. NC_009617.1.
YP_001308199.1. NC_009617.1.

3D structure databases

ProteinModelPortali A6LSB3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290402.Cbei_1059.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR33243 ; ABR33243 ; Cbei_1059 .
GeneIDi 5292287.
KEGGi cbe:Cbei_1059.
PATRICi 19346078. VBICloBei69853_1085.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi MGESEAN.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci CBEI290402:GHL5-1131-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51743 / NCIMB 8052.

Entry informationi

Entry nameiPUR9_CLOB8
AccessioniPrimary (citable) accession number: A6LSB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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