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A6LSB3 (PUR9_CLOB8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:Cbei_1059
OrganismClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) [Complete proteome] [HAMAP]
Taxonomic identifier290402 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 502502Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000076478

Sequences

Sequence LengthMass (Da)Tools
A6LSB3 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 73FC8E2B42D35974

FASTA50256,188
        10         20         30         40         50         60 
MKKRALISVF DKEGVLDFAK FLVSKDVEIV STGGTYKYLK ENGLNVIEIN EVTDFPEMLD 

        70         80         90        100        110        120 
GRVKTLHPLV HAGILAIRDN EEHMNTLKGR NIHTIDYVVV NLYPFFEKVK EDLEFEEKVE 

       130        140        150        160        170        180 
FIDIGGPTML RAAAKNFQDV VVISDKNDYK VVMEEIEANG ETSYKTKKKL AGKVFNLMSA 

       190        200        210        220        230        240 
YDGAISNFLL ADEEEEYPEY LSVSYKKMQS LRYGENSHQT AAVYASTMLD GAMNTFETLN 

       250        260        270        280        290        300 
GKELSYNNFK DVDIAWKCAN EFDEPACCAL KHNTPCGVAI GKDSYEAYMK AYEVDPTSIF 

       310        320        330        340        350        360 
GGIIGFNRKV DKKTAEEMVK IFLEVIAAPE YDEDALEVLK TKKNLRVLKF HNTPKADKYM 

       370        380        390        400        410        420 
VTVDGAMLVQ EEDNKLVEEI KVVTEKKPTD EEMKDLLFGM KVVKYVKSNA IVVAHNGIAL 

       430        440        450        460        470        480 
GIGGGQVNRI WPTEDALKRG KGATILASDA YFPFGDVAET AAKAGIKAII QPGGSIRDQE 

       490        500 
SIDVCNKYGI SMVFTGYRHF KH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000721 Genomic DNA. Translation: ABR33243.1.
RefSeqYP_001308199.1. NC_009617.1.

3D structure databases

ProteinModelPortalA6LSB3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290402.Cbei_1059.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR33243; ABR33243; Cbei_1059.
GeneID5292287.
KEGGcbe:Cbei_1059.
PATRIC19346078. VBICloBei69853_1085.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMAQENELAD.
OrthoDBEOG6QCDFF.
ProtClustDBPRK00881.

Enzyme and pathway databases

BioCycCBEI290402:GHL5-1131-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_CLOB8
AccessionPrimary (citable) accession number: A6LSB3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways