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A6LSB3

- PUR9_CLOB8

UniProt

A6LSB3 - PUR9_CLOB8

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciCBEI290402:GHL5-1131-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:Cbei_1059
    OrganismiClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
    Taxonomic identifieri290402 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000565: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Bifunctional purine biosynthesis protein PurHPRO_1000076478Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290402.Cbei_1059.

    Structurei

    3D structure databases

    ProteinModelPortaliA6LSB3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiMGESEAN.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6LSB3-1 [UniParc]FASTAAdd to Basket

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    MKKRALISVF DKEGVLDFAK FLVSKDVEIV STGGTYKYLK ENGLNVIEIN    50
    EVTDFPEMLD GRVKTLHPLV HAGILAIRDN EEHMNTLKGR NIHTIDYVVV 100
    NLYPFFEKVK EDLEFEEKVE FIDIGGPTML RAAAKNFQDV VVISDKNDYK 150
    VVMEEIEANG ETSYKTKKKL AGKVFNLMSA YDGAISNFLL ADEEEEYPEY 200
    LSVSYKKMQS LRYGENSHQT AAVYASTMLD GAMNTFETLN GKELSYNNFK 250
    DVDIAWKCAN EFDEPACCAL KHNTPCGVAI GKDSYEAYMK AYEVDPTSIF 300
    GGIIGFNRKV DKKTAEEMVK IFLEVIAAPE YDEDALEVLK TKKNLRVLKF 350
    HNTPKADKYM VTVDGAMLVQ EEDNKLVEEI KVVTEKKPTD EEMKDLLFGM 400
    KVVKYVKSNA IVVAHNGIAL GIGGGQVNRI WPTEDALKRG KGATILASDA 450
    YFPFGDVAET AAKAGIKAII QPGGSIRDQE SIDVCNKYGI SMVFTGYRHF 500
    KH 502
    Length:502
    Mass (Da):56,188
    Last modified:July 24, 2007 - v1
    Checksum:i73FC8E2B42D35974
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000721 Genomic DNA. Translation: ABR33243.1.
    RefSeqiWP_011968402.1. NC_009617.1.
    YP_001308199.1. NC_009617.1.

    Genome annotation databases

    EnsemblBacteriaiABR33243; ABR33243; Cbei_1059.
    GeneIDi5292287.
    KEGGicbe:Cbei_1059.
    PATRICi19346078. VBICloBei69853_1085.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000721 Genomic DNA. Translation: ABR33243.1 .
    RefSeqi WP_011968402.1. NC_009617.1.
    YP_001308199.1. NC_009617.1.

    3D structure databases

    ProteinModelPortali A6LSB3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290402.Cbei_1059.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR33243 ; ABR33243 ; Cbei_1059 .
    GeneIDi 5292287.
    KEGGi cbe:Cbei_1059.
    PATRICi 19346078. VBICloBei69853_1085.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi MGESEAN.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci CBEI290402:GHL5-1131-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51743 / NCIMB 8052.

    Entry informationi

    Entry nameiPUR9_CLOB8
    AccessioniPrimary (citable) accession number: A6LSB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3