A6LS61 (SURE_CLOB8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	Cbei_1007

Organism

Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) [Complete proteome] [HAMAP]

Taxonomic identifier

290402 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	5'-nucleotidase surE HAMAP MF_00060		PRO_1000075021
Sites
	Metal binding	8	1	Divalent metal cation By similarity
	Metal binding	9	1	Divalent metal cation By similarity
	Metal binding	39	1	Divalent metal cation By similarity
	Metal binding	95	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6LS61 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 19F5FF8A6BAD89C4	FASTA	253	27,948
	10 20 30 40 50 60 MNILITNDDG INAPGIIALA KEISKEHKVT IVAPKDQKSA SSHSISIHSP IKIKEEFIEG 70 80 90 100 110 120 LDCKAYSVSG TPADCTQVGL SFLKENIELV ISGINKGPNV GTDILYSGTV SAAIEGTIYG 130 140 150 160 170 180 IPSIAVSMDV EYGKDDEDYS KAVKWAIKVL DIAKEEYLKS DVVLNLNIPN FNERDIKGIK 190 200 210 220 230 240 VCKIGRSTYK TEYILLESNE EGDLYTTKGT RNAIKEEESD LYYLYQGYVT LTPLHFDFTD 250 FAILSDVTKI FEK

References

[1]

"Complete sequence of Clostridium beijerinckii NCIMB 8052." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Tapia R., Brainard J., Schmutz J., Larimer F. , Land M., Hauser L., Kyrpides N., Mikhailova N., Bennet G., Cann I., Chen J.-S., Contreras A.L., Jones D., Kashket E., Mitchell W., Stoddard S., Schwarz W., Qureshi N., Young M., Shi Z., Ezeji T., White B., Blaschek H., Richardson P. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51743 / NCIMB 8052.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000721 Genomic DNA. Translation: ABR33191.1.
RefSeq	YP_001308147.1. NC_009617.1.
3D structure databases
ProteinModelPortal	A6LS61.
ModBase	Search...
Protein-protein interaction databases
STRING	A6LS61.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5292235.
GenomeReviews	Gene locus Cbei_1007 in contig CP000721_GR.
KEGG	cbe:Cbei_1007.
PATRIC	19345972. VBICloBei69853_1032.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0496.
HOGENOM	HBG600532.
OMA	MEGAARS.
ProtClustDB	PRK13933.
Enzyme and pathway databases
BioCyc	CBEI290402:CBEI_1007-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_CLOB8

Accession

Primary (citable) accession number: A6LS61

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	July 24, 2007
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program