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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (Cbei_0485), Pyruvate kinase (Cbei_1412), Pyruvate kinase (Cbei_4851)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38Substrate1
Binding sitei117Substrate1
Binding sitei150Substrate1
Binding sitei201ATP1
Binding sitei291ATP; via carbonyl oxygen1
Binding sitei322ATP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi348 – 351ATP4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:Cbei_0598
OrganismiClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Taxonomic identifieri290402 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000565 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000765841 – 391Phosphoglycerate kinaseAdd BLAST391

Proteomic databases

PRIDEiA6LR05.

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi290402.Cbei_0598.

Structurei

3D structure databases

ProteinModelPortaliA6LR05.
SMRiA6LR05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 25Substrate binding3
Regioni61 – 64Substrate binding4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.

Phylogenomic databases

eggNOGiENOG4105BZA. Bacteria.
COG0126. LUCA.
HOGENOMiHOG000227108.
KOiK00927.
OMAiDMIFDIG.
OrthoDBiPOG091H00YN.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 2 hits.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiView protein in InterPro
IPR001576. Phosphoglycerate_kinase.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
IPR036043. Phosphoglycerate_kinase_sf.
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiView protein in Pfam
PF00162. PGK. 1 hit.
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiView protein in PROSITE
PS00111. PGLYCERATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

A6LR05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFNKKTIED IEVSGKKVLV RCDFNVPLKD GVITDENRLV GALPTIKYLV
60 70 80 90 100
EKGAKVILCS HLGKDASKSL APVATRLSEM LGKEVVFARD EEVVGENAKK
110 120 130 140 150
AVSEMKDGDI VLLENTRCRK EETKNIPEFS KELASLADVF VNDAFGTAHR
160 170 180 190 200
AHCSTVGVTD YLDTAVCGYL IQKELKFLGN AVESPVRPFV AILGGAKVSD
210 220 230 240 250
KIAVINNLLD KVNTIIIGGG MAYTFLKAQG YEIGTSLVEE DRLEYAKEMV
260 270 280 290 300
AKAAEKGVKF LLPVDHRVAA EFKDVEATIT EDQNIPVGNM GLDIGPKTET
310 320 330 340 350
LYADAIKDAK TVIWNGPMGV FEFENYNKGT IAVAKAMADA DATTIIGGGD
360 370 380 390
SAAAVNILGF GDKMTHISTG GGASLEFLEG KVLPGIAALN D
Length:391
Mass (Da):41,877
Last modified:July 24, 2007 - v1
Checksum:i9061088C6A5B02A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000721 Genomic DNA. Translation: ABR32785.1.
RefSeqiWP_011967946.1. NC_009617.1.

Genome annotation databases

EnsemblBacteriaiABR32785; ABR32785; Cbei_0598.
KEGGicbe:Cbei_0598.

Similar proteinsi

Entry informationi

Entry nameiPGK_CLOB8
AccessioniPrimary (citable) accession number: A6LR05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: October 25, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families