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A6LR05 (PGK_CLOB8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:Cbei_0598
OrganismClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) [Complete proteome] [HAMAP]
Taxonomic identifier290402 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_1000076584

Regions

Nucleotide binding348 – 3514ATP By similarity
Region23 – 253Substrate binding By similarity
Region61 – 644Substrate binding By similarity

Sites

Binding site381Substrate By similarity
Binding site1171Substrate By similarity
Binding site1501Substrate By similarity
Binding site2011ATP By similarity
Binding site2911ATP; via carbonyl oxygen By similarity
Binding site3221ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A6LR05 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 9061088C6A5B02A8

FASTA39141,877
        10         20         30         40         50         60 
MNFNKKTIED IEVSGKKVLV RCDFNVPLKD GVITDENRLV GALPTIKYLV EKGAKVILCS 

        70         80         90        100        110        120 
HLGKDASKSL APVATRLSEM LGKEVVFARD EEVVGENAKK AVSEMKDGDI VLLENTRCRK 

       130        140        150        160        170        180 
EETKNIPEFS KELASLADVF VNDAFGTAHR AHCSTVGVTD YLDTAVCGYL IQKELKFLGN 

       190        200        210        220        230        240 
AVESPVRPFV AILGGAKVSD KIAVINNLLD KVNTIIIGGG MAYTFLKAQG YEIGTSLVEE 

       250        260        270        280        290        300 
DRLEYAKEMV AKAAEKGVKF LLPVDHRVAA EFKDVEATIT EDQNIPVGNM GLDIGPKTET 

       310        320        330        340        350        360 
LYADAIKDAK TVIWNGPMGV FEFENYNKGT IAVAKAMADA DATTIIGGGD SAAAVNILGF 

       370        380        390 
GDKMTHISTG GGASLEFLEG KVLPGIAALN D 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000721 Genomic DNA. Translation: ABR32785.1.
RefSeqYP_001307741.1. NC_009617.1.

3D structure databases

ProteinModelPortalA6LR05.
SMRA6LR05. Positions 4-391.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290402.Cbei_0598.

Proteomic databases

PRIDEA6LR05.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR32785; ABR32785; Cbei_0598.
GeneID5291829.
KEGGcbe:Cbei_0598.
PATRIC19345126. VBICloBei69853_0614.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227108.
KOK00927.
OMAFGLADKM.
OrthoDBEOG64N9Z0.
ProtClustDBPRK00073.

Enzyme and pathway databases

BioCycCBEI290402:GHL5-663-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_CLOB8
AccessionPrimary (citable) accession number: A6LR05
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways