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Protein

Thymidine kinase

Gene

tdk

Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptorUniRule annotation1
Metal bindingi146ZincUniRule annotation1
Metal bindingi148ZincUniRule annotation1
Metal bindingi184ZincUniRule annotation1
Metal bindingi187ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi88 – 91ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciCBEI290402:G1G93-462-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Cbei_0402Imported
OrganismiClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)Imported
Taxonomic identifieri290402 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000565 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi290402.Cbei_0402

Structurei

3D structure databases

ProteinModelPortaliA6LQG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107SV9 Bacteria
COG1435 LUCA
HOGENOMiHOG000076391
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

A6LQG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLYFRYGA MNSGKSTHLM QVAYNYEERG MKVVIIKPRI DNKGGDTLVS
60 70 80 90 100
RLGVNRRVDL LVSDQDDIFQ IISNYIKENN KIDCILVDEV QFLRESQIDQ
110 120 130 140 150
LFEIAVKINI PIICYGLRTD FKRNGFEGST RLLLLAHSIE EMKTICACGR
160 170 180 190
KAVFNGRKIN NKFVFEGEQI AIDDEDNVEY ESLCGECYYK YKEN
Length:194
Mass (Da):22,436
Last modified:July 24, 2007 - v1
Checksum:i1656D2A3F53614E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000721 Genomic DNA Translation: ABR32590.1
RefSeqiWP_011967751.1, NC_009617.1

Genome annotation databases

EnsemblBacteriaiABR32590; ABR32590; Cbei_0402
KEGGicbe:Cbei_0402

Similar proteinsi

Entry informationi

Entry nameiA6LQG0_CLOB8
AccessioniPrimary (citable) accession number: A6LQG0
Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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