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A6LPL1

- FTHS_CLOB8

UniProt

A6LPL1 - FTHS_CLOB8

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBEI290402:GHL5-121-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Cbei_0101
OrganismiClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Taxonomic identifieri290402 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000565: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000087650Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi290402.Cbei_0101.

Structurei

3D structure databases

ProteinModelPortaliA6LPL1.
SMRiA6LPL1. Positions 4-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6LPL1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSDIQIAQE AKMEPIKNVA EKLGLCEDDI EYYGKYKCKI SLDVYDKVKN
60 70 80 90 100
NNNGKLVLVT AINPTPAGEG KSTVTVGLGQ ALNRIGKKAV IALREPSLGP
110 120 130 140 150
VFGIKGGAAG GGYAQVVPME DINLHFTGDM HAITSANNLL SAAIDNHIHQ
160 170 180 190 200
GNVLRIDSRR IVFKRVMDMN DRALRHIIVG MGGKVNGFVR EDGFNITVAS
210 220 230 240 250
EIMAILCLAS DLEDLKERMG NIVIAYNLDG NPVYAKELEI QGAMALLMKD
260 270 280 290 300
AIKPNLVQTL ENTPALIHGG PFANIAHGCN SIMATKLALK LGDVVITEAG
310 320 330 340 350
FGADLGAEKF FDIKCRYGNL EPECVVVVAT IRALKHHGGV AKTELNIPNV
360 370 380 390 400
EALKDGIANL EKQIENIKKF KITPVVAINK FVTDSSEEVE FIKDFCDRIG
410 420 430 440 450
VKVALCDVWA KGGEGGIDLA NIVLDALENS ESNFEPIYDK EKSIREKIFT
460 470 480 490 500
IASEIYGADK VNYTPAAKKQ IDELEKFKLD KLPICMAKTQ YSLSDNPSLL
510 520 530 540 550
ARPTGFDITV KEVRVSNGAG FIVVQTGDIM TMPGLPKVPA ANKMDVLKSG

EIIGLF
Length:556
Mass (Da):60,270
Last modified:July 24, 2007 - v1
Checksum:iD32E9899A16C3302
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000721 Genomic DNA. Translation: ABR32291.1.
RefSeqiYP_001307247.1. NC_009617.1.

Genome annotation databases

EnsemblBacteriaiABR32291; ABR32291; Cbei_0101.
GeneIDi5291335.
KEGGicbe:Cbei_0101.
PATRICi19344016. VBICloBei69853_0104.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000721 Genomic DNA. Translation: ABR32291.1 .
RefSeqi YP_001307247.1. NC_009617.1.

3D structure databases

ProteinModelPortali A6LPL1.
SMRi A6LPL1. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 290402.Cbei_0101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR32291 ; ABR32291 ; Cbei_0101 .
GeneIDi 5291335.
KEGGi cbe:Cbei_0101.
PATRICi 19344016. VBICloBei69853_0104.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CBEI290402:GHL5-121-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51743 / NCIMB 8052.

Entry informationi

Entry nameiFTHS_CLOB8
AccessioniPrimary (citable) accession number: A6LPL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: October 1, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3