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A6LPL1 (FTHS_CLOB8) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Cbei_0101
OrganismClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum) [Complete proteome] [HAMAP]
Taxonomic identifier290402 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000087650

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A6LPL1 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: D32E9899A16C3302

FASTA55660,270
        10         20         30         40         50         60 
MKSDIQIAQE AKMEPIKNVA EKLGLCEDDI EYYGKYKCKI SLDVYDKVKN NNNGKLVLVT 

        70         80         90        100        110        120 
AINPTPAGEG KSTVTVGLGQ ALNRIGKKAV IALREPSLGP VFGIKGGAAG GGYAQVVPME 

       130        140        150        160        170        180 
DINLHFTGDM HAITSANNLL SAAIDNHIHQ GNVLRIDSRR IVFKRVMDMN DRALRHIIVG 

       190        200        210        220        230        240 
MGGKVNGFVR EDGFNITVAS EIMAILCLAS DLEDLKERMG NIVIAYNLDG NPVYAKELEI 

       250        260        270        280        290        300 
QGAMALLMKD AIKPNLVQTL ENTPALIHGG PFANIAHGCN SIMATKLALK LGDVVITEAG 

       310        320        330        340        350        360 
FGADLGAEKF FDIKCRYGNL EPECVVVVAT IRALKHHGGV AKTELNIPNV EALKDGIANL 

       370        380        390        400        410        420 
EKQIENIKKF KITPVVAINK FVTDSSEEVE FIKDFCDRIG VKVALCDVWA KGGEGGIDLA 

       430        440        450        460        470        480 
NIVLDALENS ESNFEPIYDK EKSIREKIFT IASEIYGADK VNYTPAAKKQ IDELEKFKLD 

       490        500        510        520        530        540 
KLPICMAKTQ YSLSDNPSLL ARPTGFDITV KEVRVSNGAG FIVVQTGDIM TMPGLPKVPA 

       550 
ANKMDVLKSG EIIGLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000721 Genomic DNA. Translation: ABR32291.1.
RefSeqYP_001307247.1. NC_009617.1.

3D structure databases

ProteinModelPortalA6LPL1.
SMRA6LPL1. Positions 4-554.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING290402.Cbei_0101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR32291; ABR32291; Cbei_0101.
GeneID5291335.
KEGGcbe:Cbei_0101.
PATRIC19344016. VBICloBei69853_0104.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycCBEI290402:GHL5-121-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_CLOB8
AccessionPrimary (citable) accession number: A6LPL1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways