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A6LPL1

- FTHS_CLOB8

UniProt

A6LPL1 - FTHS_CLOB8

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBEI290402:GHL5-121-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Cbei_0101
    OrganismiClostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) (Clostridium acetobutylicum)
    Taxonomic identifieri290402 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000565: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000087650Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi290402.Cbei_0101.

    Structurei

    3D structure databases

    ProteinModelPortaliA6LPL1.
    SMRiA6LPL1. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6LPL1-1 [UniParc]FASTAAdd to Basket

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    MKSDIQIAQE AKMEPIKNVA EKLGLCEDDI EYYGKYKCKI SLDVYDKVKN    50
    NNNGKLVLVT AINPTPAGEG KSTVTVGLGQ ALNRIGKKAV IALREPSLGP 100
    VFGIKGGAAG GGYAQVVPME DINLHFTGDM HAITSANNLL SAAIDNHIHQ 150
    GNVLRIDSRR IVFKRVMDMN DRALRHIIVG MGGKVNGFVR EDGFNITVAS 200
    EIMAILCLAS DLEDLKERMG NIVIAYNLDG NPVYAKELEI QGAMALLMKD 250
    AIKPNLVQTL ENTPALIHGG PFANIAHGCN SIMATKLALK LGDVVITEAG 300
    FGADLGAEKF FDIKCRYGNL EPECVVVVAT IRALKHHGGV AKTELNIPNV 350
    EALKDGIANL EKQIENIKKF KITPVVAINK FVTDSSEEVE FIKDFCDRIG 400
    VKVALCDVWA KGGEGGIDLA NIVLDALENS ESNFEPIYDK EKSIREKIFT 450
    IASEIYGADK VNYTPAAKKQ IDELEKFKLD KLPICMAKTQ YSLSDNPSLL 500
    ARPTGFDITV KEVRVSNGAG FIVVQTGDIM TMPGLPKVPA ANKMDVLKSG 550
    EIIGLF 556
    Length:556
    Mass (Da):60,270
    Last modified:July 24, 2007 - v1
    Checksum:iD32E9899A16C3302
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000721 Genomic DNA. Translation: ABR32291.1.
    RefSeqiYP_001307247.1. NC_009617.1.

    Genome annotation databases

    EnsemblBacteriaiABR32291; ABR32291; Cbei_0101.
    GeneIDi5291335.
    KEGGicbe:Cbei_0101.
    PATRICi19344016. VBICloBei69853_0104.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000721 Genomic DNA. Translation: ABR32291.1 .
    RefSeqi YP_001307247.1. NC_009617.1.

    3D structure databases

    ProteinModelPortali A6LPL1.
    SMRi A6LPL1. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 290402.Cbei_0101.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR32291 ; ABR32291 ; Cbei_0101 .
    GeneIDi 5291335.
    KEGGi cbe:Cbei_0101.
    PATRICi 19344016. VBICloBei69853_0104.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CBEI290402:GHL5-121-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51743 / NCIMB 8052.

    Entry informationi

    Entry nameiFTHS_CLOB8
    AccessioniPrimary (citable) accession number: A6LPL1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3