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A6LP69

- GCSPB_THEM4

UniProt

A6LP69 - GCSPB_THEM4

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Thermosipho melanesiensis (strain BI429 / DSM 12029)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTMEL391009:GHM1-1950-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:Tmel_1887
OrganismiThermosipho melanesiensis (strain BI429 / DSM 12029)
Taxonomic identifieri391009 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
ProteomesiUP000001110: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000045707Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei265 – 2651N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi391009.Tmel_1887.

Structurei

3D structure databases

ProteinModelPortaliA6LP69.
SMRiA6LP69. Positions 2-477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A6LP69-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTIFELSKEG RKAYNLPKNN IKDYGFDFPN HLMRGKEPRL PQVSELDIVR
60 70 80 90 100
HYTNLAAKNY AVDVGFYPLG SCTMKYNPKI NEKLASLEGF TMIHPCQPRE
110 120 130 140 150
VTQGALQLMY ELKEMLCEIS GMDDMTLIPS AGAHGELTGM LIARAYHLSR
160 170 180 190 200
GDTKRKKAIV PDSAHGTNPA SAMMAGFEVV ELKSGKDGRI DLEELEKHLD
210 220 230 240 250
DEVAVLLLTN PNTLGLFEKD IIKIAETVHK HGALLYYDGA NLNAILGRTR
260 270 280 290 300
PGDMGFDIVH LNLHKTFSTP HGMGGPGSGP VGVKKHLAKF LPIPEIIKES
310 320 330 340 350
DVYKFNYNKS ESIGFIRSFY GNFSVLVRAY VYIKTMGNDG LKKVGQMAVL
360 370 380 390 400
NANYLRKKVS KIMDIAYPDM CMHEFVATCE KLTKETGVKA LDIAKRLLDY
410 420 430 440 450
GIHAPTMYFP LIVHEDFMIE PTETESKDTL DEFTKILEKI FIEAKENPEL
460 470 480
VKNAPYTTPV RRLDEASASR KPIVKYNFEE E
Length:481
Mass (Da):54,036
Last modified:July 24, 2007 - v1
Checksum:iE620A2A7190D3AF9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000716 Genomic DNA. Translation: ABR31720.1.
RefSeqiYP_001307105.1. NC_009616.1.

Genome annotation databases

EnsemblBacteriaiABR31720; ABR31720; Tmel_1887.
GeneIDi5297775.
KEGGitme:Tmel_1887.
PATRICi23925089. VBITheMel19269_1957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000716 Genomic DNA. Translation: ABR31720.1 .
RefSeqi YP_001307105.1. NC_009616.1.

3D structure databases

ProteinModelPortali A6LP69.
SMRi A6LP69. Positions 2-477.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391009.Tmel_1887.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR31720 ; ABR31720 ; Tmel_1887 .
GeneIDi 5297775.
KEGGi tme:Tmel_1887.
PATRICi 23925089. VBITheMel19269_1957.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci TMEL391009:GHM1-1950-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BI429 / DSM 12029.

Entry informationi

Entry nameiGCSPB_THEM4
AccessioniPrimary (citable) accession number: A6LP69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3