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Protein

Aminomethyltransferase

Gene

gcvT

Organism
Thermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine.UniRule annotation

Catalytic activityi

[Protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

BioCyciTMEL391009:G1G91-1942-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
AminomethyltransferaseUniRule annotation (EC:2.1.2.10UniRule annotation)
Alternative name(s):
Glycine cleavage system T proteinUniRule annotation
Gene namesi
Name:gcvTUniRule annotation
Ordered Locus Names:Tmel_1885
OrganismiThermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429)
Taxonomic identifieri391009 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesFervidobacteriaceaeThermosipho
Proteomesi
  • UP000001110 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000477241 – 363AminomethyltransferaseAdd BLAST363

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi391009.Tmel_1885

Structurei

3D structure databases

ProteinModelPortaliA6LP67
SMRiA6LP67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D43 Bacteria
COG0404 LUCA
HOGENOMiHOG000239381
KOiK00605
OMAiMPVQYPA
OrthoDBiPOG091H04FV

Family and domain databases

Gene3Di3.30.1360.1202 hits
HAMAPiMF_00259 GcvT, 1 hit
InterProiView protein in InterPro
IPR006223 GCS_T
IPR022903 GCS_T_bac
IPR028896 GCST/YgfZ/DmdA
IPR013977 GCV_T_C
IPR006222 GCV_T_N
IPR029043 GcvT/YgfZ_C
IPR027266 TrmE/GcvT_dom1
PfamiView protein in Pfam
PF01571 GCV_T, 1 hit
PF08669 GCV_T_C, 1 hit
PIRSFiPIRSF006487 GcvT, 1 hit
SUPFAMiSSF101790 SSF101790, 1 hit
TIGRFAMsiTIGR00528 gcvT, 1 hit

Sequencei

Sequence statusi: Complete.

A6LP67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYTPLYEEH VKLGAKMVDF AGFNMPIQYT SIKDEVLAVR KNVGMFDVSH
60 70 80 90 100
MGEVIVEGKD STKFVDFLIT NDFKNLKPGE IVYTAMCNEN GGFVDDLLAY
110 120 130 140 150
KISEEKAMLV INASNIEKDF SWMKKISESF DVTLENKSDE YVLIAVQGPN
160 170 180 190 200
AQKTLQKITN VDLEQIGYYT FTEGNVLDIK AIISRTGYTG EDGFEIYTTD
210 220 230 240 250
KDGIIKIWKK LLNLNVIPAG LGARDCLRLE ASLLLYGNDM DETITPLEVG
260 270 280 290 300
IKWAVKFEKD FMGKEALKRQ LEEGTSRRLK GFKIIDKGIA RHGYKVFKDG
310 320 330 340 350
KEIGYVTSGT FSPTLNQAIG MALIEKGYKS GEIIEIEIRN KLVKAEIVKM
360
PFYRGSVKSK KKG
Length:363
Mass (Da):40,855
Last modified:July 24, 2007 - v1
Checksum:i93B118746EFFAD7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000716 Genomic DNA Translation: ABR31718.1
RefSeqiWP_012058076.1, NC_009616.1

Genome annotation databases

EnsemblBacteriaiABR31718; ABR31718; Tmel_1885
KEGGitme:Tmel_1885

Similar proteinsi

Entry informationi

Entry nameiGCST_THEM4
AccessioniPrimary (citable) accession number: A6LP67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome