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A6LP67 (GCST_THEM4) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Aminomethyltransferase
EC=2.1.2.10
Alternative name(s):
Glycine cleavage system T protein
Gene names
Name:gcvT
Ordered Locus Names:Tmel_1885
OrganismThermosipho melanesiensis (strain BI429 / DSM 12029) [Complete proteome] [HAMAP]
Taxonomic identifier391009 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermosipho

Protein attributes

Sequence length363 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259

Catalytic activity

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvT family.

Ontologies

Keywords
   Molecular functionAminotransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycine catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular functionaminomethyltransferase activity

Inferred from electronic annotation. Source: EC

transaminase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 363363Aminomethyltransferase HAMAP MF_00259
PRO_1000047724

Sequences

Sequence LengthMass (Da)Tools
A6LP67 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 93B118746EFFAD7A

FASTA36340,855
        10         20         30         40         50         60 
MKYTPLYEEH VKLGAKMVDF AGFNMPIQYT SIKDEVLAVR KNVGMFDVSH MGEVIVEGKD 

        70         80         90        100        110        120 
STKFVDFLIT NDFKNLKPGE IVYTAMCNEN GGFVDDLLAY KISEEKAMLV INASNIEKDF 

       130        140        150        160        170        180 
SWMKKISESF DVTLENKSDE YVLIAVQGPN AQKTLQKITN VDLEQIGYYT FTEGNVLDIK 

       190        200        210        220        230        240 
AIISRTGYTG EDGFEIYTTD KDGIIKIWKK LLNLNVIPAG LGARDCLRLE ASLLLYGNDM 

       250        260        270        280        290        300 
DETITPLEVG IKWAVKFEKD FMGKEALKRQ LEEGTSRRLK GFKIIDKGIA RHGYKVFKDG 

       310        320        330        340        350        360 
KEIGYVTSGT FSPTLNQAIG MALIEKGYKS GEIIEIEIRN KLVKAEIVKM PFYRGSVKSK 


KKG

« Hide

References

[1]"Complete sequence of Thermosipho melanesiensis BI429."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BI429 / DSM 12029.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000716 Genomic DNA. Translation: ABR31718.1.
RefSeqYP_001307103.1. NC_009616.1.

3D structure databases

ProteinModelPortalA6LP67.
SMRA6LP67. Positions 1-358.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6LP67.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5297571.
GenomeReviewsGene locus Tmel_1885 in contig CP000716_GR.
KEGGtme:Tmel_1885.
NMPDRfig|391009.4.peg.1928.
PATRIC23925085. VBITheMel19269_1955.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0404.
HOGENOMHBG299834.
OMAKALYGGM.
ProtClustDBPRK00389.

Family and domain databases

HAMAPMF_00259. GcvT.
[Tree]
InterProIPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR006223. GcvT.
IPR022903. NH2_Me_Trfase.
[Graphical view]
KOK00605.
PANTHERPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFPIRSF006487. GcvT. 1 hit.
TIGRFAMsTIGR00528. GcvT. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCST_THEM4
AccessionPrimary (citable) accession number: A6LP67
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: January 25, 2012
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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