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A6LNF5

- PNP_THEM4

UniProt

A6LNF5 - PNP_THEM4

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, Tmel_1612
Organism
Thermosipho melanesiensis (strain BI429 / DSM 12029)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi493 – 4931Magnesium By similarity
Metal bindingi499 – 4991Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciTMEL391009:GHM1-1674-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Tmel_1612
OrganismiThermosipho melanesiensis (strain BI429 / DSM 12029)
Taxonomic identifieri391009 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
ProteomesiUP000001110: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 699699Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329911Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391009.Tmel_1612.

Structurei

3D structure databases

ProteinModelPortaliA6LNF5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini560 – 62061KH
Add
BLAST
Domaini630 – 69768S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6LNF5-1 [UniParc]FASTAAdd to Basket

« Hide

MLKFREWSKE FFGRKLTIQY GKVAKQSSGA AWVQFGDSVV LATANISDRV    50
IEGVDFVPLT VEYQEKFYAA GKIPGGFIKR EGKPTESAIL SARLIDRPIR 100
PLFPKYLRND VQLIVTVLSV DGDTPPDVTG IFAASLALNF SKIPFQGIVA 150
GVRIGYVDGE FVIFPTEEQL KNSKLDIVVA GSKDAITMVE GEAKEVTEEE 200
MVQALMVAHE AIKKLIEFEE EILREFNVEK MEIEEPKPKD ELIGRFEELL 250
VENELRKRLL IKEKLERSLK LKEYKEELIS KIFEEFEIDD EEKLTQEMLL 300
KELFDEKAKK LMRKIIINEG IRADGRTPEE IRPITCEVGV LPRTHGSALF 350
TRGETQSLGI VTLGAPMEEQ IVDTIMEEGT KRFILHYNFP PFSVGEVKPL 400
RGPGRREIGH GHLAERALKA VAPDEEDFPY VVRVVSEILE SNGSSSMATV 450
CSGSLALMDA GVPIKTHVAG VAMGLIVDEE NEVVLTDIQG LEDHWGDMDF 500
KVAGTRNGIT AFQMDCKIAG VGEELLKKAL KQARVARMRI LDIMFETIKE 550
PRKSLSPYAP LIANIEIDPM KVGELIGPGG KVIKSIVKEF DVEISIDDVT 600
GKVSVYGKDQ NKVNQAIEYI KTLTREIEVG DMFEGKITRI EPYGLFVELM 650
PGKIGLAHSS KLGNDSKEFR KKYKVGDVIK VVVVNIDDSG RIQLGKAEE 699
Length:699
Mass (Da):78,031
Last modified:July 24, 2007 - v1
Checksum:i32BA1193D8A26D06
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000716 Genomic DNA. Translation: ABR31456.1.
RefSeqiWP_012057815.1. NC_009616.1.
YP_001306841.1. NC_009616.1.

Genome annotation databases

EnsemblBacteriaiABR31456; ABR31456; Tmel_1612.
GeneIDi5296783.
KEGGitme:Tmel_1612.
PATRICi23924515. VBITheMel19269_1671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000716 Genomic DNA. Translation: ABR31456.1 .
RefSeqi WP_012057815.1. NC_009616.1.
YP_001306841.1. NC_009616.1.

3D structure databases

ProteinModelPortali A6LNF5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391009.Tmel_1612.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR31456 ; ABR31456 ; Tmel_1612 .
GeneIDi 5296783.
KEGGi tme:Tmel_1612.
PATRICi 23924515. VBITheMel19269_1671.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci TMEL391009:GHM1-1674-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BI429 / DSM 12029.

Entry informationi

Entry nameiPNP_THEM4
AccessioniPrimary (citable) accession number: A6LNF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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