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A6LN85

- NADK_THEM4

UniProt

A6LN85 - NADK_THEM4

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Protein

NAD kinase

Gene
nadK, Tmel_1541
Organism
Thermosipho melanesiensis (strain BI429 / DSM 12029)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511Proton acceptor By similarity
Binding sitei56 – 561NAD By similarity
Binding sitei124 – 1241NAD By similarity
Binding sitei140 – 1401NAD By similarity
Binding sitei142 – 1421NAD By similarity
Binding sitei177 – 1771NAD; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi51 – 522NAD By similarity
Nucleotide bindingi113 – 1142NAD By similarity
Nucleotide bindingi153 – 1586NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciTMEL391009:GHM1-1602-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:Tmel_1541
OrganismiThermosipho melanesiensis (strain BI429 / DSM 12029)
Taxonomic identifieri391009 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
ProteomesiUP000001110: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 251251NAD kinaseUniRule annotationPRO_1000005452Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391009.Tmel_1541.

Structurei

3D structure databases

ProteinModelPortaliA6LN85.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiGPIMLPN.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

A6LN85-1 [UniParc]FASTAAdd to Basket

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MKVLGIFHKP SLKSVAEKFS EILFDENFHV EYVGSEIPSI EVDLTLVLGG    50
DGTFLKAAHK VRNPLVGFKG GRLGFLSSYT LGDFDKFLED LKNENFERDI 100
RYFLKAGDFY TLNEVLLIRD PVQKMVDIQI FFQDGDFYFH ADGLIISTPT 150
GSTGYSLSLG GPIMLPNVNS FVITPVAPQF LASRSIIVPD DEEIIVRIDQ 200
EINLILDGMD FGKVREVNLK KSRRRIVILR PKDYNFSKSI KEKLGYGKRF 250
L 251
Length:251
Mass (Da):28,453
Last modified:July 24, 2007 - v1
Checksum:i913D3822AAA77512
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000716 Genomic DNA. Translation: ABR31386.1.
RefSeqiYP_001306771.1. NC_009616.1.

Genome annotation databases

EnsemblBacteriaiABR31386; ABR31386; Tmel_1541.
GeneIDi5297193.
KEGGitme:Tmel_1541.
PATRICi23924371. VBITheMel19269_1600.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000716 Genomic DNA. Translation: ABR31386.1 .
RefSeqi YP_001306771.1. NC_009616.1.

3D structure databases

ProteinModelPortali A6LN85.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391009.Tmel_1541.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR31386 ; ABR31386 ; Tmel_1541 .
GeneIDi 5297193.
KEGGi tme:Tmel_1541.
PATRICi 23924371. VBITheMel19269_1600.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi GPIMLPN.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci TMEL391009:GHM1-1602-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BI429 / DSM 12029.

Entry informationi

Entry nameiNADK_THEM4
AccessioniPrimary (citable) accession number: A6LN85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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