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A6LMG3

- PGK_THEM4

UniProt

A6LMG3 - PGK_THEM4

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Thermosipho melanesiensis (strain BI429 / DSM 12029)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361SubstrateUniRule annotation
    Binding sitei118 – 1181SubstrateUniRule annotation
    Binding sitei151 – 1511SubstrateUniRule annotation
    Binding sitei201 – 2011ATPUniRule annotation
    Binding sitei293 – 2931ATP; via carbonyl oxygenUniRule annotation
    Binding sitei324 – 3241ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi353 – 3564ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTMEL391009:GHM1-1319-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
    Gene namesi
    Name:pgkUniRule annotation
    Ordered Locus Names:Tmel_1265
    OrganismiThermosipho melanesiensis (strain BI429 / DSM 12029)
    Taxonomic identifieri391009 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
    ProteomesiUP000001110: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 402402Phosphoglycerate kinasePRO_1000058085Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi391009.Tmel_1265.

    Structurei

    3D structure databases

    ProteinModelPortaliA6LMG3.
    SMRiA6LMG3. Positions 2-398.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 233Substrate bindingUniRule annotation
    Regioni59 – 624Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227108.
    KOiK00927.
    OMAiFPVDYVT.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6LMG3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKLTIRDID IKNKKVIMRV DFNVPLKDGK ITDDTRIVEA LPTIKYAIEN    50
    NAVVILLSHL GRPKGERKPE FSLKPVSERL SELLGKQVTF VPELYGEEVK 100
    MAIDNAKPGD VILLENTRFD KGETKNDPEL AKKWADLADI HVNDAFGTAH 150
    RAHASNVGIS QYIPSVAGFL MEKEIKFLSK ATLNPEKPYV VILGGAKVSD 200
    KIGVITNLLN KADKILIGGA MMFTFLKALG KNVGSSLVEE DKLDLAKRIL 250
    EEAKEKGVEF VLPVDAVCAQ KIESGVETKT FRINDGIPEG WMGLDIGPES 300
    IKLFKEKISG AKTIVWNGPM GVFEIEDFET GTKEVAISIA AETEKGATTV 350
    IGGGDSAAAI AKFNLKNKVS HVSTGGGASL EFLEGKELPG IASIASKKKI 400
    EN 402
    Length:402
    Mass (Da):43,611
    Last modified:July 24, 2007 - v1
    Checksum:i51D4CC3FE60AF0F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000716 Genomic DNA. Translation: ABR31114.1.
    RefSeqiYP_001306499.1. NC_009616.1.

    Genome annotation databases

    EnsemblBacteriaiABR31114; ABR31114; Tmel_1265.
    GeneIDi5297643.
    KEGGitme:Tmel_1265.
    PATRICi23923795. VBITheMel19269_1317.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000716 Genomic DNA. Translation: ABR31114.1 .
    RefSeqi YP_001306499.1. NC_009616.1.

    3D structure databases

    ProteinModelPortali A6LMG3.
    SMRi A6LMG3. Positions 2-398.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391009.Tmel_1265.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR31114 ; ABR31114 ; Tmel_1265 .
    GeneIDi 5297643.
    KEGGi tme:Tmel_1265.
    PATRICi 23923795. VBITheMel19269_1317.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227108.
    KOi K00927.
    OMAi FPVDYVT.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci TMEL391009:GHM1-1319-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BI429 / DSM 12029.

    Entry informationi

    Entry nameiPGK_THEM4
    AccessioniPrimary (citable) accession number: A6LMG3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3