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A6LMA9

- A6LMA9_THEM4

UniProt

A6LMA9 - A6LMA9_THEM4

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Protein
Thymidine kinase
Gene
tdk, Tmel_1206
Organism
Thermosipho melanesiensis (strain BI429 / DSM 12029)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841Proton acceptor By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATP By similarityUniRule annotation
Nucleotide bindingi83 – 864ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. thymidine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingSAAS annotations, Nucleotide-binding, ZincSAAS annotations

Enzyme and pathway databases

BioCyciTMEL391009:GHM1-1259-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Tmel_1206Imported
OrganismiThermosipho melanesiensis (strain BI429 / DSM 12029)Imported
Taxonomic identifieri391009 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
ProteomesiUP000001110: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Protein-protein interaction databases

STRINGi391009.Tmel_1206.

Structurei

3D structure databases

ProteinModelPortaliA6LMA9.
SMRiA6LMA9. Positions 2-181.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiQAICLSC.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6LMA9-1 [UniParc]FASTAAdd to Basket

« Hide

MVGKITVITG PMYSGKTTEL LSFVEIYNIG RKKTIVFKPS IDNRYGEDIV    50
STHTGFKVSA IRISKSREIL DYIRDSIDAV FVDEIQFFDL ELVDVVKELV 100
FKGIDVYCAG LDISYLENPF ETTAKLLAMA DEVIKKKAVC EKCGEHRATY 150
SYKIIPNGGE IDVGGKEKYI ALCRKCLSEI KKQEVIL 187
Length:187
Mass (Da):21,049
Last modified:July 24, 2007 - v1
Checksum:i60F8E0EE299DBDBC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000716 Genomic DNA. Translation: ABR31060.1.
RefSeqiYP_001306445.1. NC_009616.1.

Genome annotation databases

EnsemblBacteriaiABR31060; ABR31060; Tmel_1206.
GeneIDi5296911.
KEGGitme:Tmel_1206.
PATRICi23923671. VBITheMel19269_1256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000716 Genomic DNA. Translation: ABR31060.1 .
RefSeqi YP_001306445.1. NC_009616.1.

3D structure databases

ProteinModelPortali A6LMA9.
SMRi A6LMA9. Positions 2-181.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391009.Tmel_1206.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR31060 ; ABR31060 ; Tmel_1206 .
GeneIDi 5296911.
KEGGi tme:Tmel_1206.
PATRICi 23923671. VBITheMel19269_1256.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi QAICLSC.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci TMEL391009:GHM1-1259-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BI429 / DSM 12029.

Entry informationi

Entry nameiA6LMA9_THEM4
AccessioniPrimary (citable) accession number: A6LMA9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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