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Protein

Thymidine kinase

Gene

tdk

Organism
Thermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei84Proton acceptorUniRule annotation1
Metal bindingi140ZincUniRule annotation1
Metal bindingi143ZincUniRule annotation1
Metal bindingi173ZincUniRule annotation1
Metal bindingi176ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17ATPUniRule annotation8
Nucleotide bindingi83 – 86ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Tmel_1206Imported
OrganismiThermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429)Imported
Taxonomic identifieri391009 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesFervidobacteriaceaeThermosipho
Proteomesi
  • UP000001110 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi391009.Tmel_1206.

Structurei

3D structure databases

ProteinModelPortaliA6LMA9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076390.
KOiK00857.
OMAiKEQFGWI.
OrthoDBiPOG091H0659.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

A6LMA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGKITVITG PMYSGKTTEL LSFVEIYNIG RKKTIVFKPS IDNRYGEDIV
60 70 80 90 100
STHTGFKVSA IRISKSREIL DYIRDSIDAV FVDEIQFFDL ELVDVVKELV
110 120 130 140 150
FKGIDVYCAG LDISYLENPF ETTAKLLAMA DEVIKKKAVC EKCGEHRATY
160 170 180
SYKIIPNGGE IDVGGKEKYI ALCRKCLSEI KKQEVIL
Length:187
Mass (Da):21,049
Last modified:July 24, 2007 - v1
Checksum:i60F8E0EE299DBDBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000716 Genomic DNA. Translation: ABR31060.1.
RefSeqiWP_012057419.1. NC_009616.1.

Genome annotation databases

EnsemblBacteriaiABR31060; ABR31060; Tmel_1206.
KEGGitme:Tmel_1206.

Similar proteinsi

Entry informationi

Entry nameiA6LMA9_THEM4
AccessioniPrimary (citable) accession number: A6LMA9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: September 27, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported