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A6LMA9

- A6LMA9_THEM4

UniProt

A6LMA9 - A6LMA9_THEM4

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Protein

Thymidine kinase

Gene

tdk

Organism
Thermosipho melanesiensis (strain BI429 / DSM 12029)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATPUniRule annotation
Nucleotide bindingi83 – 864ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
  3. thymidine kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingSAAS annotation, Nucleotide-binding, ZincSAAS annotation

Enzyme and pathway databases

BioCyciTMEL391009:GHM1-1259-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Tmel_1206Imported
OrganismiThermosipho melanesiensis (strain BI429 / DSM 12029)Imported
Taxonomic identifieri391009 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
ProteomesiUP000001110: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi391009.Tmel_1206.

Structurei

3D structure databases

ProteinModelPortaliA6LMA9.
SMRiA6LMA9. Positions 2-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiQAICLSC.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6LMA9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGKITVITG PMYSGKTTEL LSFVEIYNIG RKKTIVFKPS IDNRYGEDIV
60 70 80 90 100
STHTGFKVSA IRISKSREIL DYIRDSIDAV FVDEIQFFDL ELVDVVKELV
110 120 130 140 150
FKGIDVYCAG LDISYLENPF ETTAKLLAMA DEVIKKKAVC EKCGEHRATY
160 170 180
SYKIIPNGGE IDVGGKEKYI ALCRKCLSEI KKQEVIL
Length:187
Mass (Da):21,049
Last modified:July 24, 2007 - v1
Checksum:i60F8E0EE299DBDBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000716 Genomic DNA. Translation: ABR31060.1.
RefSeqiWP_012057419.1. NC_009616.1.
YP_001306445.1. NC_009616.1.

Genome annotation databases

EnsemblBacteriaiABR31060; ABR31060; Tmel_1206.
GeneIDi5296911.
KEGGitme:Tmel_1206.
PATRICi23923671. VBITheMel19269_1256.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000716 Genomic DNA. Translation: ABR31060.1 .
RefSeqi WP_012057419.1. NC_009616.1.
YP_001306445.1. NC_009616.1.

3D structure databases

ProteinModelPortali A6LMA9.
SMRi A6LMA9. Positions 2-181.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391009.Tmel_1206.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR31060 ; ABR31060 ; Tmel_1206 .
GeneIDi 5296911.
KEGGi tme:Tmel_1206.
PATRICi 23923671. VBITheMel19269_1256.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi QAICLSC.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci TMEL391009:GHM1-1259-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BI429 / DSM 12029Imported.

Entry informationi

Entry nameiA6LMA9_THEM4
AccessioniPrimary (citable) accession number: A6LMA9
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: November 26, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3