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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Thermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei145May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciTMEL391009:G1G91-557-MONOMER
UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Tmel_0531
OrganismiThermosipho melanesiensis (strain DSM 12029 / CIP 104789 / BI429)
Taxonomic identifieri391009 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesFervidobacteriaceaeThermosipho
Proteomesi
  • UP000001110 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000686711 – 259GTP cyclohydrolase FolE2Add BLAST259

Interactioni

Protein-protein interaction databases

STRINGi391009.Tmel_0531

Structurei

3D structure databases

ProteinModelPortaliA6LKE7
SMRiA6LKE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000280679
KOiK09007
OMAiHNQRGRG
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit
TIGRFAMsiTIGR00294 TIGR00294, 1 hit

Sequencei

Sequence statusi: Complete.

A6LKE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDVQSEKDT REIPLKHVGI KKLKYPVQVL DRENKVQNTV ADINMYVDLP
60 70 80 90 100
KDFRGTHMSR FLEVFNKFHL KIDPKTIKKI LDDLKQTLKA QSAKIEIMFP
110 120 130 140 150
YFLKKKAPVT KIESYMEYLC GFSAYDGPQK CEFYTIVEVS VQTLCPCSKE
160 170 180 190 200
ISKYNAHNQR ANVRIEVETS ELVWFEELIE IAEDSASVPL FSLLKRPDEK
210 220 230 240 250
FVTEKAYENP KFVEDVARDI AIRLKDNPKI NWFKVEVESY ESIHNHNAFA

CVDSTIMEV
Length:259
Mass (Da):30,197
Last modified:July 24, 2007 - v1
Checksum:iF2C4AC7DE655927F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000716 Genomic DNA Translation: ABR30398.1
RefSeqiWP_012056759.1, NC_009616.1

Genome annotation databases

EnsemblBacteriaiABR30398; ABR30398; Tmel_0531
KEGGitme:Tmel_0531

Similar proteinsi

Entry informationi

Entry nameiGCH4_THEM4
AccessioniPrimary (citable) accession number: A6LKE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 24, 2007
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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