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A6LKE7

- GCH4_THEM4

UniProt

A6LKE7 - GCH4_THEM4

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Thermosipho melanesiensis (strain BI429 / DSM 12029)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei145 – 1451May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciTMEL391009:GHM1-555-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Tmel_0531
    OrganismiThermosipho melanesiensis (strain BI429 / DSM 12029)
    Taxonomic identifieri391009 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
    ProteomesiUP000001110: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 259259GTP cyclohydrolase FolE2PRO_1000068671Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391009.Tmel_0531.

    Structurei

    3D structure databases

    ProteinModelPortaliA6LKE7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6LKE7-1 [UniParc]FASTAAdd to Basket

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    MKDVQSEKDT REIPLKHVGI KKLKYPVQVL DRENKVQNTV ADINMYVDLP    50
    KDFRGTHMSR FLEVFNKFHL KIDPKTIKKI LDDLKQTLKA QSAKIEIMFP 100
    YFLKKKAPVT KIESYMEYLC GFSAYDGPQK CEFYTIVEVS VQTLCPCSKE 150
    ISKYNAHNQR ANVRIEVETS ELVWFEELIE IAEDSASVPL FSLLKRPDEK 200
    FVTEKAYENP KFVEDVARDI AIRLKDNPKI NWFKVEVESY ESIHNHNAFA 250
    CVDSTIMEV 259
    Length:259
    Mass (Da):30,197
    Last modified:July 24, 2007 - v1
    Checksum:iF2C4AC7DE655927F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000716 Genomic DNA. Translation: ABR30398.1.
    RefSeqiYP_001305783.1. NC_009616.1.

    Genome annotation databases

    EnsemblBacteriaiABR30398; ABR30398; Tmel_0531.
    GeneIDi5298114.
    KEGGitme:Tmel_0531.
    PATRICi23922223. VBITheMel19269_0557.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000716 Genomic DNA. Translation: ABR30398.1 .
    RefSeqi YP_001305783.1. NC_009616.1.

    3D structure databases

    ProteinModelPortali A6LKE7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391009.Tmel_0531.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR30398 ; ABR30398 ; Tmel_0531 .
    GeneIDi 5298114.
    KEGGi tme:Tmel_0531.
    PATRICi 23922223. VBITheMel19269_0557.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci TMEL391009:GHM1-555-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BI429 / DSM 12029.

    Entry informationi

    Entry nameiGCH4_THEM4
    AccessioniPrimary (citable) accession number: A6LKE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3