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A6LKE7

- GCH4_THEM4

UniProt

A6LKE7 - GCH4_THEM4

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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Thermosipho melanesiensis (strain BI429 / DSM 12029)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei145 – 1451May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciTMEL391009:GHM1-555-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Tmel_0531
OrganismiThermosipho melanesiensis (strain BI429 / DSM 12029)
Taxonomic identifieri391009 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
ProteomesiUP000001110: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259GTP cyclohydrolase FolE2PRO_1000068671Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391009.Tmel_0531.

Structurei

3D structure databases

ProteinModelPortaliA6LKE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiDVQSSRD.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

A6LKE7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKDVQSEKDT REIPLKHVGI KKLKYPVQVL DRENKVQNTV ADINMYVDLP
60 70 80 90 100
KDFRGTHMSR FLEVFNKFHL KIDPKTIKKI LDDLKQTLKA QSAKIEIMFP
110 120 130 140 150
YFLKKKAPVT KIESYMEYLC GFSAYDGPQK CEFYTIVEVS VQTLCPCSKE
160 170 180 190 200
ISKYNAHNQR ANVRIEVETS ELVWFEELIE IAEDSASVPL FSLLKRPDEK
210 220 230 240 250
FVTEKAYENP KFVEDVARDI AIRLKDNPKI NWFKVEVESY ESIHNHNAFA

CVDSTIMEV
Length:259
Mass (Da):30,197
Last modified:July 24, 2007 - v1
Checksum:iF2C4AC7DE655927F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000716 Genomic DNA. Translation: ABR30398.1.
RefSeqiYP_001305783.1. NC_009616.1.

Genome annotation databases

EnsemblBacteriaiABR30398; ABR30398; Tmel_0531.
GeneIDi5298114.
KEGGitme:Tmel_0531.
PATRICi23922223. VBITheMel19269_0557.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000716 Genomic DNA. Translation: ABR30398.1 .
RefSeqi YP_001305783.1. NC_009616.1.

3D structure databases

ProteinModelPortali A6LKE7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391009.Tmel_0531.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR30398 ; ABR30398 ; Tmel_0531 .
GeneIDi 5298114.
KEGGi tme:Tmel_0531.
PATRICi 23922223. VBITheMel19269_0557.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi DVQSSRD.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci TMEL391009:GHM1-555-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BI429 / DSM 12029.

Entry informationi

Entry nameiGCH4_THEM4
AccessioniPrimary (citable) accession number: A6LKE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 24, 2007
Last modified: October 1, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3