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A6LJS5

- FTHS_THEM4

UniProt

A6LJS5 - FTHS_THEM4

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Tmel_0304
Organism
Thermosipho melanesiensis (strain BI429 / DSM 12029)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTMEL391009:GHM1-320-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Tmel_0304
OrganismiThermosipho melanesiensis (strain BI429 / DSM 12029)
Taxonomic identifieri391009 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
ProteomesiUP000001110: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 551551Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000068798Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391009.Tmel_0304.

Structurei

3D structure databases

ProteinModelPortaliA6LJS5.
SMRiA6LJS5. Positions 4-549.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6LJS5-1 [UniParc]FASTAAdd to Basket

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MKTDIEIARE AKLKRISDIA KDIGIEEKYL EPYGKYIAKV DLKFLKTLNN    50
KKDGKLILVT AITPTPAGEG KTTTSIGLSM ALNRLGKKSI VTLREPSLGP 100
VFGIKGGAAG GGYSQVLPME NINLHFTGDI HAISSAHNLI SAVIDSHIKF 150
GNNLNINPTK VFWKRTMDMN DRALRQIIVG LGGNANGLPR EDGFIITAAS 200
EIMAILCLAK DLKDLKERLG NIVVAESFDK KLVRVKDLKI EGALTALLKD 250
AINPNIVQTI ENTPAFIHGG PFANIAHGTN SIIATKLALK LTDYVVTEAG 300
FAADLGAEKF LDFVTQVGNF DVNAVVLVAT IKALKYHGGI KKDELNKENV 350
DAMLKGMENL KTHIENLKLY NVPVVVALNV FASDTTNELK AFSEHCNAPH 400
ALVRAFEKGS KGTIELANTV LENISDSKHI PILNPEMSIE EKIETLATKV 450
YRARKVIYTD TAKSKLKFLK RHGFETLPVI VAKTQSSISD DPKKLNAPRD 500
YNFTIRDFEL SAGAGFVVAL AGEIMRMPGL SKIPNAVNID VDEDGNIVGL 550
S 551
Length:551
Mass (Da):59,916
Last modified:July 24, 2007 - v1
Checksum:i1ACF712B6DCC63BF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000716 Genomic DNA. Translation: ABR30176.1.
RefSeqiWP_012056537.1. NC_009616.1.
YP_001305561.1. NC_009616.1.

Genome annotation databases

EnsemblBacteriaiABR30176; ABR30176; Tmel_0304.
GeneIDi5296808.
KEGGitme:Tmel_0304.
PATRICi23921725. VBITheMel19269_0314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000716 Genomic DNA. Translation: ABR30176.1 .
RefSeqi WP_012056537.1. NC_009616.1.
YP_001305561.1. NC_009616.1.

3D structure databases

ProteinModelPortali A6LJS5.
SMRi A6LJS5. Positions 4-549.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391009.Tmel_0304.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR30176 ; ABR30176 ; Tmel_0304 .
GeneIDi 5296808.
KEGGi tme:Tmel_0304.
PATRICi 23921725. VBITheMel19269_0314.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci TMEL391009:GHM1-320-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BI429 / DSM 12029.

Entry informationi

Entry nameiFTHS_THEM4
AccessioniPrimary (citable) accession number: A6LJS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 24, 2007
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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