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A6LJS5

- FTHS_THEM4

UniProt

A6LJS5 - FTHS_THEM4

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermosipho melanesiensis (strain BI429 / DSM 12029)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTMEL391009:GHM1-320-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Tmel_0304
    OrganismiThermosipho melanesiensis (strain BI429 / DSM 12029)
    Taxonomic identifieri391009 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
    ProteomesiUP000001110: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 551551Formate--tetrahydrofolate ligasePRO_1000068798Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391009.Tmel_0304.

    Structurei

    3D structure databases

    ProteinModelPortaliA6LJS5.
    SMRiA6LJS5. Positions 4-549.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6LJS5-1 [UniParc]FASTAAdd to Basket

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    MKTDIEIARE AKLKRISDIA KDIGIEEKYL EPYGKYIAKV DLKFLKTLNN    50
    KKDGKLILVT AITPTPAGEG KTTTSIGLSM ALNRLGKKSI VTLREPSLGP 100
    VFGIKGGAAG GGYSQVLPME NINLHFTGDI HAISSAHNLI SAVIDSHIKF 150
    GNNLNINPTK VFWKRTMDMN DRALRQIIVG LGGNANGLPR EDGFIITAAS 200
    EIMAILCLAK DLKDLKERLG NIVVAESFDK KLVRVKDLKI EGALTALLKD 250
    AINPNIVQTI ENTPAFIHGG PFANIAHGTN SIIATKLALK LTDYVVTEAG 300
    FAADLGAEKF LDFVTQVGNF DVNAVVLVAT IKALKYHGGI KKDELNKENV 350
    DAMLKGMENL KTHIENLKLY NVPVVVALNV FASDTTNELK AFSEHCNAPH 400
    ALVRAFEKGS KGTIELANTV LENISDSKHI PILNPEMSIE EKIETLATKV 450
    YRARKVIYTD TAKSKLKFLK RHGFETLPVI VAKTQSSISD DPKKLNAPRD 500
    YNFTIRDFEL SAGAGFVVAL AGEIMRMPGL SKIPNAVNID VDEDGNIVGL 550
    S 551
    Length:551
    Mass (Da):59,916
    Last modified:July 24, 2007 - v1
    Checksum:i1ACF712B6DCC63BF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000716 Genomic DNA. Translation: ABR30176.1.
    RefSeqiWP_012056537.1. NC_009616.1.
    YP_001305561.1. NC_009616.1.

    Genome annotation databases

    EnsemblBacteriaiABR30176; ABR30176; Tmel_0304.
    GeneIDi5296808.
    KEGGitme:Tmel_0304.
    PATRICi23921725. VBITheMel19269_0314.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000716 Genomic DNA. Translation: ABR30176.1 .
    RefSeqi WP_012056537.1. NC_009616.1.
    YP_001305561.1. NC_009616.1.

    3D structure databases

    ProteinModelPortali A6LJS5.
    SMRi A6LJS5. Positions 4-549.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391009.Tmel_0304.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR30176 ; ABR30176 ; Tmel_0304 .
    GeneIDi 5296808.
    KEGGi tme:Tmel_0304.
    PATRICi 23921725. VBITheMel19269_0314.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci TMEL391009:GHM1-320-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BI429 / DSM 12029.

    Entry informationi

    Entry nameiFTHS_THEM4
    AccessioniPrimary (citable) accession number: A6LJS5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3