Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A6LJS5 (FTHS_THEM4) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Tmel_0304
OrganismThermosipho melanesiensis (strain BI429 / DSM 12029) [Complete proteome] [HAMAP]
Taxonomic identifier391009 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000068798

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A6LJS5 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 1ACF712B6DCC63BF

FASTA55159,916
        10         20         30         40         50         60 
MKTDIEIARE AKLKRISDIA KDIGIEEKYL EPYGKYIAKV DLKFLKTLNN KKDGKLILVT 

        70         80         90        100        110        120 
AITPTPAGEG KTTTSIGLSM ALNRLGKKSI VTLREPSLGP VFGIKGGAAG GGYSQVLPME 

       130        140        150        160        170        180 
NINLHFTGDI HAISSAHNLI SAVIDSHIKF GNNLNINPTK VFWKRTMDMN DRALRQIIVG 

       190        200        210        220        230        240 
LGGNANGLPR EDGFIITAAS EIMAILCLAK DLKDLKERLG NIVVAESFDK KLVRVKDLKI 

       250        260        270        280        290        300 
EGALTALLKD AINPNIVQTI ENTPAFIHGG PFANIAHGTN SIIATKLALK LTDYVVTEAG 

       310        320        330        340        350        360 
FAADLGAEKF LDFVTQVGNF DVNAVVLVAT IKALKYHGGI KKDELNKENV DAMLKGMENL 

       370        380        390        400        410        420 
KTHIENLKLY NVPVVVALNV FASDTTNELK AFSEHCNAPH ALVRAFEKGS KGTIELANTV 

       430        440        450        460        470        480 
LENISDSKHI PILNPEMSIE EKIETLATKV YRARKVIYTD TAKSKLKFLK RHGFETLPVI 

       490        500        510        520        530        540 
VAKTQSSISD DPKKLNAPRD YNFTIRDFEL SAGAGFVVAL AGEIMRMPGL SKIPNAVNID 

       550 
VDEDGNIVGL S 

« Hide

References

[1]"Complete sequence of Thermosipho melanesiensis BI429."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BI429 / DSM 12029.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000716 Genomic DNA. Translation: ABR30176.1.
RefSeqYP_001305561.1. NC_009616.1.

3D structure databases

ProteinModelPortalA6LJS5.
SMRA6LJS5. Positions 4-549.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING391009.Tmel_0304.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR30176; ABR30176; Tmel_0304.
GeneID5296808.
KEGGtme:Tmel_0304.
PATRIC23921725. VBITheMel19269_0314.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycTMEL391009:GHM1-320-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_THEM4
AccessionPrimary (citable) accession number: A6LJS5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways