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A6LJM9

- SYL_THEM4

UniProt

A6LJM9 - SYL_THEM4

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Protein

Leucine--tRNA ligase

Gene
leuS, Tmel_0256
Organism
Thermosipho melanesiensis (strain BI429 / DSM 12029)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei583 – 5831ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTMEL391009:GHM1-269-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Tmel_0256
OrganismiThermosipho melanesiensis (strain BI429 / DSM 12029)
Taxonomic identifieri391009 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
ProteomesiUP000001110: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 823823Leucine--tRNA ligaseUniRule annotationPRO_1000071115Add
BLAST

Proteomic databases

PRIDEiA6LJM9.

Interactioni

Protein-protein interaction databases

STRINGi391009.Tmel_0256.

Structurei

3D structure databases

ProteinModelPortaliA6LJM9.
SMRiA6LJM9. Positions 1-759.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5111"HIGH" regionUniRule annotationAdd
BLAST
Motifi580 – 5845"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6LJM9-1 [UniParc]FASTAAdd to Basket

« Hide

MKEYIPGEIE PKWQKVWAES KVFETPQRSD KKKFYNLVMF PYPSGTLHVG    50
HVKNYVIGDI VARYKRMKGY NVLHPFGYDA FGLPAENAAI KNKIHPEVWT 100
FKNIDIIRNQ IKKIGISYDW SREVITCTEE YYKWTQWIFL KLYENGLAYK 150
KKAAVNWCPS CQTVLANEQV VDGKCERCGT EVTMKHLEQW YFKITDYAEK 200
LLNDIDKLRG WPENVKIMQK NWIGKSTGAE IDFPVDRLDM KIKVFTTRPD 250
TIWGVTFMAI APESPLVEML VTDERKDELS QFLKKVSLED RFKRTSLEAE 300
KEGFFLGRYA INPVTGEKIP IYVANYILYE YGTGAIMAVP AHDQRDFDFA 350
KKYGISIRVV IDNPEESIDV EKMEKAYEEE GIMVNSGPFN GMRSTLALEK 400
IIEYLEEKGI GKRSVQYKLR DWLISRQRYW GAPIPIVYCE KCGIVPVPEK 450
DLPVKLPKDV EFLPTGQSPL SLDEQFLNTT CPKCGGPAKR EADTMDTFVD 500
SSWYYLRYIN PKLEDKPFDT EDINYWMPVD QYIGGVEHAV LHLLYSRFIT 550
KVLYDLGYLK FEEPFENLFT QGMIYKDGWK MSKSKGNVVS PDEMIEKYGA 600
DTLRTYILFM APPEKDAEWS DAGIEGVNRF LKRLWNNIYS ILPRIKDVKV 650
EKIELKNKQE KDLRRKLHQS IKKITEDIEG GFKFNTAIAG LMELNNNLSE 700
YLNSAKDLNL PLLRELVEKL TLILSPFAPH MAEEIWHDLG NDTLVVNEEW 750
PAYDENALKV DEVTVIIQIN GKVRGKIQTK VDVSEGEIKK LAFENAKIAS 800
YVDGREIVKV IYVKNKLLNI VVK 823
Length:823
Mass (Da):95,319
Last modified:July 24, 2007 - v1
Checksum:i3202B8451A516850
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000716 Genomic DNA. Translation: ABR30130.1.
RefSeqiYP_001305515.1. NC_009616.1.

Genome annotation databases

EnsemblBacteriaiABR30130; ABR30130; Tmel_0256.
GeneIDi5297116.
KEGGitme:Tmel_0256.
PATRICi23921623. VBITheMel19269_0265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000716 Genomic DNA. Translation: ABR30130.1 .
RefSeqi YP_001305515.1. NC_009616.1.

3D structure databases

ProteinModelPortali A6LJM9.
SMRi A6LJM9. Positions 1-759.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391009.Tmel_0256.

Proteomic databases

PRIDEi A6LJM9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR30130 ; ABR30130 ; Tmel_0256 .
GeneIDi 5297116.
KEGGi tme:Tmel_0256.
PATRICi 23921623. VBITheMel19269_0265.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci TMEL391009:GHM1-269-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BI429 / DSM 12029.

Entry informationi

Entry nameiSYL_THEM4
AccessioniPrimary (citable) accession number: A6LJM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 24, 2007
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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