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A6LJM9

- SYL_THEM4

UniProt

A6LJM9 - SYL_THEM4

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Thermosipho melanesiensis (strain BI429 / DSM 12029)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei583 – 5831ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTMEL391009:GHM1-269-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Tmel_0256
OrganismiThermosipho melanesiensis (strain BI429 / DSM 12029)
Taxonomic identifieri391009 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
ProteomesiUP000001110: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 823823Leucine--tRNA ligasePRO_1000071115Add
BLAST

Proteomic databases

PRIDEiA6LJM9.

Interactioni

Protein-protein interaction databases

STRINGi391009.Tmel_0256.

Structurei

3D structure databases

ProteinModelPortaliA6LJM9.
SMRiA6LJM9. Positions 1-759.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 5111"HIGH" regionAdd
BLAST
Motifi580 – 5845"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6LJM9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEYIPGEIE PKWQKVWAES KVFETPQRSD KKKFYNLVMF PYPSGTLHVG
60 70 80 90 100
HVKNYVIGDI VARYKRMKGY NVLHPFGYDA FGLPAENAAI KNKIHPEVWT
110 120 130 140 150
FKNIDIIRNQ IKKIGISYDW SREVITCTEE YYKWTQWIFL KLYENGLAYK
160 170 180 190 200
KKAAVNWCPS CQTVLANEQV VDGKCERCGT EVTMKHLEQW YFKITDYAEK
210 220 230 240 250
LLNDIDKLRG WPENVKIMQK NWIGKSTGAE IDFPVDRLDM KIKVFTTRPD
260 270 280 290 300
TIWGVTFMAI APESPLVEML VTDERKDELS QFLKKVSLED RFKRTSLEAE
310 320 330 340 350
KEGFFLGRYA INPVTGEKIP IYVANYILYE YGTGAIMAVP AHDQRDFDFA
360 370 380 390 400
KKYGISIRVV IDNPEESIDV EKMEKAYEEE GIMVNSGPFN GMRSTLALEK
410 420 430 440 450
IIEYLEEKGI GKRSVQYKLR DWLISRQRYW GAPIPIVYCE KCGIVPVPEK
460 470 480 490 500
DLPVKLPKDV EFLPTGQSPL SLDEQFLNTT CPKCGGPAKR EADTMDTFVD
510 520 530 540 550
SSWYYLRYIN PKLEDKPFDT EDINYWMPVD QYIGGVEHAV LHLLYSRFIT
560 570 580 590 600
KVLYDLGYLK FEEPFENLFT QGMIYKDGWK MSKSKGNVVS PDEMIEKYGA
610 620 630 640 650
DTLRTYILFM APPEKDAEWS DAGIEGVNRF LKRLWNNIYS ILPRIKDVKV
660 670 680 690 700
EKIELKNKQE KDLRRKLHQS IKKITEDIEG GFKFNTAIAG LMELNNNLSE
710 720 730 740 750
YLNSAKDLNL PLLRELVEKL TLILSPFAPH MAEEIWHDLG NDTLVVNEEW
760 770 780 790 800
PAYDENALKV DEVTVIIQIN GKVRGKIQTK VDVSEGEIKK LAFENAKIAS
810 820
YVDGREIVKV IYVKNKLLNI VVK
Length:823
Mass (Da):95,319
Last modified:July 24, 2007 - v1
Checksum:i3202B8451A516850
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000716 Genomic DNA. Translation: ABR30130.1.
RefSeqiYP_001305515.1. NC_009616.1.

Genome annotation databases

EnsemblBacteriaiABR30130; ABR30130; Tmel_0256.
GeneIDi5297116.
KEGGitme:Tmel_0256.
PATRICi23921623. VBITheMel19269_0265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000716 Genomic DNA. Translation: ABR30130.1 .
RefSeqi YP_001305515.1. NC_009616.1.

3D structure databases

ProteinModelPortali A6LJM9.
SMRi A6LJM9. Positions 1-759.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391009.Tmel_0256.

Proteomic databases

PRIDEi A6LJM9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR30130 ; ABR30130 ; Tmel_0256 .
GeneIDi 5297116.
KEGGi tme:Tmel_0256.
PATRICi 23921623. VBITheMel19269_0265.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci TMEL391009:GHM1-269-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BI429 / DSM 12029.

Entry informationi

Entry nameiSYL_THEM4
AccessioniPrimary (citable) accession number: A6LJM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3