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A6LJM9

- SYL_THEM4

UniProt

A6LJM9 - SYL_THEM4

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Thermosipho melanesiensis (strain BI429 / DSM 12029)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei583 – 5831ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTMEL391009:GHM1-269-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Tmel_0256
    OrganismiThermosipho melanesiensis (strain BI429 / DSM 12029)
    Taxonomic identifieri391009 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho
    ProteomesiUP000001110: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 823823Leucine--tRNA ligasePRO_1000071115Add
    BLAST

    Proteomic databases

    PRIDEiA6LJM9.

    Interactioni

    Protein-protein interaction databases

    STRINGi391009.Tmel_0256.

    Structurei

    3D structure databases

    ProteinModelPortaliA6LJM9.
    SMRiA6LJM9. Positions 1-759.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 5111"HIGH" regionAdd
    BLAST
    Motifi580 – 5845"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6LJM9-1 [UniParc]FASTAAdd to Basket

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    MKEYIPGEIE PKWQKVWAES KVFETPQRSD KKKFYNLVMF PYPSGTLHVG    50
    HVKNYVIGDI VARYKRMKGY NVLHPFGYDA FGLPAENAAI KNKIHPEVWT 100
    FKNIDIIRNQ IKKIGISYDW SREVITCTEE YYKWTQWIFL KLYENGLAYK 150
    KKAAVNWCPS CQTVLANEQV VDGKCERCGT EVTMKHLEQW YFKITDYAEK 200
    LLNDIDKLRG WPENVKIMQK NWIGKSTGAE IDFPVDRLDM KIKVFTTRPD 250
    TIWGVTFMAI APESPLVEML VTDERKDELS QFLKKVSLED RFKRTSLEAE 300
    KEGFFLGRYA INPVTGEKIP IYVANYILYE YGTGAIMAVP AHDQRDFDFA 350
    KKYGISIRVV IDNPEESIDV EKMEKAYEEE GIMVNSGPFN GMRSTLALEK 400
    IIEYLEEKGI GKRSVQYKLR DWLISRQRYW GAPIPIVYCE KCGIVPVPEK 450
    DLPVKLPKDV EFLPTGQSPL SLDEQFLNTT CPKCGGPAKR EADTMDTFVD 500
    SSWYYLRYIN PKLEDKPFDT EDINYWMPVD QYIGGVEHAV LHLLYSRFIT 550
    KVLYDLGYLK FEEPFENLFT QGMIYKDGWK MSKSKGNVVS PDEMIEKYGA 600
    DTLRTYILFM APPEKDAEWS DAGIEGVNRF LKRLWNNIYS ILPRIKDVKV 650
    EKIELKNKQE KDLRRKLHQS IKKITEDIEG GFKFNTAIAG LMELNNNLSE 700
    YLNSAKDLNL PLLRELVEKL TLILSPFAPH MAEEIWHDLG NDTLVVNEEW 750
    PAYDENALKV DEVTVIIQIN GKVRGKIQTK VDVSEGEIKK LAFENAKIAS 800
    YVDGREIVKV IYVKNKLLNI VVK 823
    Length:823
    Mass (Da):95,319
    Last modified:July 24, 2007 - v1
    Checksum:i3202B8451A516850
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000716 Genomic DNA. Translation: ABR30130.1.
    RefSeqiYP_001305515.1. NC_009616.1.

    Genome annotation databases

    EnsemblBacteriaiABR30130; ABR30130; Tmel_0256.
    GeneIDi5297116.
    KEGGitme:Tmel_0256.
    PATRICi23921623. VBITheMel19269_0265.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000716 Genomic DNA. Translation: ABR30130.1 .
    RefSeqi YP_001305515.1. NC_009616.1.

    3D structure databases

    ProteinModelPortali A6LJM9.
    SMRi A6LJM9. Positions 1-759.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391009.Tmel_0256.

    Proteomic databases

    PRIDEi A6LJM9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR30130 ; ABR30130 ; Tmel_0256 .
    GeneIDi 5297116.
    KEGGi tme:Tmel_0256.
    PATRICi 23921623. VBITheMel19269_0265.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci TMEL391009:GHM1-269-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BI429 / DSM 12029.

    Entry informationi

    Entry nameiSYL_THEM4
    AccessioniPrimary (citable) accession number: A6LJM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3