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A6LJI3 (UPPP_THEM4) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Tmel_0210
OrganismThermosipho melanesiensis (strain BI429 / DSM 12029) [Complete proteome] [HAMAP]
Taxonomic identifier391009 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermosipho

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000318867

Regions

Transmembrane35 – 5521Helical; Potential
Transmembrane73 – 9321Helical; Potential
Transmembrane100 – 12021Helical; Potential
Transmembrane146 – 16621Helical; Potential
Transmembrane171 – 19121Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane229 – 24921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A6LJI3 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 13CDA6B9F4E09334

FASTA25027,087
        10         20         30         40         50         60 
MEIILGIVQG LTEFLPISSS GHLSVFSKLF NLKPDLSVFA LLHLATLAAI VIFVGKELTE 

        70         80         90        100        110        120 
IIKGLIKLEK NYINLTLKII VSTIPAAIFG VLLESKIEAS LSNLKIISFF FLVTSAALLI 

       130        140        150        160        170        180 
SDKIKGNKDL STLTYKDALV IGIMQALAIF PGISRSGFTL FGSLLIGLER EIALKYSFLV 

       190        200        210        220        230        240 
SIPVILGAGL LEIKNISLNS YSISSAIVAF FFGLLSLFIL KKATISKNLK IFSAYCIFIS 

       250 
IFSFVLGGIK 

« Hide

References

[1]"Complete sequence of Thermosipho melanesiensis BI429."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BI429 / DSM 12029.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000716 Genomic DNA. Translation: ABR30084.1.
RefSeqYP_001305469.1. NC_009616.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING391009.Tmel_0210.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR30084; ABR30084; Tmel_0210.
GeneID5298418.
KEGGtme:Tmel_0210.
PATRIC23921531. VBITheMel19269_0219.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAWEFLATG.
OrthoDBEOG6QP13M.
ProtClustDBCLSK2791989.

Enzyme and pathway databases

BioCycTMEL391009:GHM1-223-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_THEM4
AccessionPrimary (citable) accession number: A6LJI3
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families