A6LJ62 (A6LJ62_THEM4) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
NH(3)-dependent NAD(+) synthetase RuleBase RU003812
EC=6.3.1.5 RuleBase RU003812

Gene names

Ordered Locus Names:

Tmel_0086

Organism

Thermosipho melanesiensis (strain BI429 / DSM 12029) [Complete proteome] [HAMAP]

Taxonomic identifier

391009 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermosipho

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. RuleBase RU003812 SAAS SAAS003694
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1. RuleBase RU004252 SAAS SAAS003694
Sequence similarities	Belongs to the NAD synthetase family. RuleBase RU003811

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU003811 SAAS SAAS003694 NAD SAAS SAAS003694 RuleBase RU003811 Nucleotide-binding
Molecular function	Ligase RuleBase RU003811 SAAS SAAS003694
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ synthase (glutamine-hydrolyzing) activity Inferred from electronic annotation. Source: InterPro NAD+ synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A6LJ62 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: A43505B4A13F22B5	FASTA	279	32,573
	10 20 30 40 50 60 MLEKIENFLY EFFKKYNFSG AVLGVSGGVD SAVVLGLLVR VLDKEKIKCF ILPERDSPKK 70 80 90 100 110 120 AINDAKLVCR HFNVDYEVKN VTKIIRVFGV YRYYPPAFFV PFKIKESFAK KRWNRYKDNS 130 140 150 160 170 180 FEYDVLGVDD EEFLKGISYY RIKHRVRMVY LYKEAEKRNF AVVGTTNKTE FLTGLYVKWG 190 200 210 220 230 240 DDSTDVEPLL HLYKTQVFEL AKVLSIPEKI LNKPASPDLI PGLNDEDIFG LDYPTLDRIL 250 260 270 KKLEENIPID DEDPNTVEKV RKLYNLGKIR NQIRNISIE

References

[1]

"Complete sequence of Thermosipho melanesiensis BI429." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BI429 / DSM 12029.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000716 Genomic DNA. Translation: ABR29963.1.
RefSeq	YP_001305348.1. NC_009616.1.
3D structure databases
ProteinModelPortal	A6LJ62.
ModBase	Search...
Protein-protein interaction databases
STRING	A6LJ62.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5297085.
GenomeReviews	Gene locus Tmel_0086 in contig CP000716_GR.
KEGG	tme:Tmel_0086.
NMPDR	fig|391009.4.peg.89.
PATRIC	23921259. VBITheMel19269_0091.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0171.
HOGENOM	HBG351567.
OMA	AHLYKSQ.
ProtClustDB	CLSK875266.
Family and domain databases
InterPro	IPR022310. NAD/GMP_synthase. IPR003694. NAD_synthase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 2 hits.
KO	K01916.
Pfam	PF02540. NAD_synthase. 2 hits. [Graphical view]
TIGRFAMs	TIGR00552. NadE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A6LJ62_THEM4

Accession

Primary (citable) accession number: A6LJ62

Entry history

Integrated into UniProtKB/TrEMBL:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)