A6LIJ8 (A6LIJ8_PARD8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 3 HAMAP MF_00108
EC=2.7.7.60 HAMAP MF_00108

Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase 3 HAMAP MF_00108
MEP cytidylyltransferase 3 HAMAP MF_00108

Gene names

Name:	ispD3 HAMAP MF_00108
Ordered Locus Names:	BDI_3828

Organism

Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) [Complete proteome] [HAMAP]

Taxonomic identifier

435591 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Parabacteroides

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108 SAAS SAAS018294 RuleBase RU003490
Catalytic activity	CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108 SAAS SAAS018294 RuleBase RU003490
Pathway	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108 SAAS SAAS018294 RuleBase RU004138
Sequence similarities	Belongs to the IspD family. HAMAP MF_00108 RuleBase RU004393

Ontologies

Keywords
Biological process	Isoprene biosynthesis HAMAP MF_00108 SAAS SAAS018294 RuleBase RU004393
Molecular function	Nucleotidyltransferase HAMAP MF_00108 SAAS SAAS018294 RuleBase RU004393 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Site	15	1	Transition state stabilizer By similarity HAMAP MF_00108
	Site	23	1	Transition state stabilizer By similarity HAMAP MF_00108
	Site	161	1	Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108
	Site	218	1	Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108

Sequences

	Sequence		Length	Mass (Da)
	A6LIJ8 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: BE1DF0B07817B813	FASTA	243	27,456
	10 20 30 40 50 60 MKNIAVIFAG GSGVRMNTRS KPKQFLELRG KPIIIYTLEL FDNHPLIDGI VVVCLESWIP 70 80 90 100 110 120 FLKKMLKKFE INKVVKIVSG GDSGQDSIYR GLCAVEDYCK DKGEENAVVL IHDGVRPLIV 130 140 150 160 170 180 DETITRNIEK VHEKGSAITV VPAIETFVIQ KEEGQMVIPD RSSCLLARAP QSFYLKDILS 190 200 210 220 230 240 IHRKNKENGN ITFIDSCSMM SYFGYKMATI EGPMENIKIT TPTDYFIFRA MVEVHENQQI FGF

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000140 Genomic DNA. Translation: ABR45512.1.
RefSeq	YP_001305134.1. NC_009615.1.
3D structure databases
ProteinModelPortal	A6LIJ8.
ModBase	Search...
Protein-protein interaction databases
STRING	A6LIJ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5308977.
GenomeReviews	Gene locus BDI_3828 in contig CP000140_GR.
KEGG	pdi:BDI_3828.
PATRIC	22850900. VBIParDis29947_3786.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1211.
HOGENOM	HBG672839.
OMA	VDETITR.
ProtClustDB	CLSK904510.
Enzyme and pathway databases
BioCyc	PDIS435591:BDI_3828-MONOMER.
Family and domain databases
HAMAP	MF_00108. IspD. [Tree]
InterPro	IPR001228. ISPD_synthase. IPR018294. ISPD_synthase_CS. [Graphical view]
KO	K00991.
Pfam	PF01128. IspD. 1 hit. [Graphical view]
PROSITE	PS01295. ISPD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A6LIJ8_PARD8

Accession

Primary (citable) accession number: A6LIJ8

Entry history

Integrated into UniProtKB/TrEMBL:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)