A6LIA1 (SYN_PARD8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Asparagine--tRNA ligase
EC=6.1.1.22

Alternative name(s):
Asparaginyl-tRNA synthetase
Short name=AsnRS

Gene names

Name:	asnS
Ordered Locus Names:	BDI_3727

Organism

Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) [Complete proteome] [HAMAP]

Taxonomic identifier

435591 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Parabacteroides

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn). HAMAP MF_00534
Subunit structure	Homodimer By similarity. HAMAP MF_00534
Subcellular location	Cytoplasm HAMAP MF_00534.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	asparaginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW asparagine-tRNA ligase activity Inferred from electronic annotation. Source: EC nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Asparagine--tRNA ligase HAMAP MF_00534		PRO_1000051412

Sequences

	Sequence		Length	Mass (Da)
	A6LIA1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 5FABEE7694285350	FASTA	468	53,353
	10 20 30 40 50 60 METIKRTKIV DVLKSDAFGT TVNVKGWVRT RRGSKQVNFI ALNDGSTINN VQIVVDVDKL 70 80 90 100 110 120 GDEFLKPITT GASISVNGIL TQSQGKGQSV EIQATEIEIF GTADPATYPL QKKGHSMEFL 130 140 150 160 170 180 REIAHLRPRT NTFGAVFRIR HNMAYAIHKF FHDRGFFYFH TPIITASDCE GAGQMFQVTT 190 200 210 220 230 240 KNLYDLKKDE NGSIIYEDDF FGKQASLTVS GQLEGELAAT ALGQIYTFGP TFRAENSNTP 250 260 270 280 290 300 RHLAEFWMIE PEVAFNDITD NMELAEEFIK YCVQWALDNC MEDIKFLNDM FDKELIARLE 310 320 330 340 350 360 GVLKDSFVRL PYTEGIKILE EAVAKGHKFE FPVYWGVDLA SEHERFLVED HFKRPVILTD 370 380 390 400 410 420 YPKEIKAFYM KQNEDGKTVR AMDVLFPKIG EIIGGSEREA DYDKLMTRID ELGIPMKDMW 430 440 450 460 WYLDTRRFGT VPHSGFGLGF ERLLLFVTGM ANIRDVIPFP RTPNNAEF

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8503 / DSM 20701 / NCTC 11152.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000140 Genomic DNA. Translation: ABR45415.1.
RefSeq	YP_001305037.1. NC_009615.1.
3D structure databases
ProteinModelPortal	A6LIA1.
ModBase	Search...
Protein-protein interaction databases
STRING	A6LIA1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5308876.
GenomeReviews	Gene locus BDI_3727 in contig CP000140_GR.
KEGG	pdi:BDI_3727.
PATRIC	22850686. VBIParDis29947_3683.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0017.
HOGENOM	HBG745843.
OMA	AIHRFFH.
ProtClustDB	PRK03932.
Enzyme and pathway databases
BioCyc	PDIS435591:BDI_3727-MONOMER.
Family and domain databases
HAMAP	MF_00534. Asn_tRNA_synth. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II. IPR004522. Asn-tRNA-synth_IIb. IPR002312. Asp/Asn-tRNA-synth_IIb. IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR004365. NA-bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
KO	K01893.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF6. PTHR22594:SF6. 1 hit.
Pfam	PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMs	TIGR00457. AsnS. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYN_PARD8

Accession

Primary (citable) accession number: A6LIA1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program