A6LI67 (ARLY_PARD8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	BDI_3689

Organism

Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) [Complete proteome] [HAMAP]

Taxonomic identifier

435591 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Parabacteroides

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	Argininosuccinate lyase HAMAP MF_00006		PRO_1000116337

Sequences

	Sequence		Length	Mass (Da)
	A6LI67 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 418DB936D7700687	FASTA	446	50,368
	10 20 30 40 50 60 MAQKLWEKNV QVDHEVDIFT VGKDREMDLY LAKYDVLGSM AHITMLESIG LLTKEELNVL 70 80 90 100 110 120 LAELRNIYAV ADRGEFIIEE GIEDVHSQVE LMLTRRLGDM GKKIHSGRSR NDQVLLDLKL 130 140 150 160 170 180 FTRSQIQELV ELVSGLFDVL ISQSNRYKDV LLPGYTHLQV AMPSSFGLWF GAYAESLVDD 190 200 210 220 230 240 LQLMQAAYRI CNRNPLGSAA GYGSSFPLNR QMTTDLLGFD SLDYNVVYAQ MGRGKMERTV 250 260 270 280 290 300 AFAMAGIAAT LSKLAFDACM FNSQNFGFIK LPDQFTTGSS IMPHKKNPDV FELTRAKCNK 310 320 330 340 350 360 LQGLPQQIIL ISNNLPSGYF RDLQIIKEVF LPAFDELKDC LRMVTHMMRE VKVNEHILDD 370 380 390 400 410 420 DKYSLLFSVE EVNRRVLAGM PFRDAYKQVG LDIEAGKFIP SKSVNHTHEG SIGNLCNESI 430 440 TAMMRSVIGS FSFERMNEAE KKLIHG

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8503 / DSM 20701 / NCTC 11152.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000140 Genomic DNA. Translation: ABR45381.1.
RefSeq	YP_001305003.1. NC_009615.1.
3D structure databases
ProteinModelPortal	A6LI67.
ModBase	Search...
Protein-protein interaction databases
STRING	A6LI67.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5308838.
GenomeReviews	Gene locus BDI_3689 in contig CP000140_GR.
KEGG	pdi:BDI_3689.
PATRIC	22850606. VBIParDis29947_3647.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0165.
HOGENOM	HBG539632.
OMA	KKNPDVF.
ProtClustDB	PRK00855.
Enzyme and pathway databases
BioCyc	PDIS435591:BDI_3689-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_PARD8

Accession

Primary (citable) accession number: A6LI67

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program