A6LHA9 (ACKA_PARD8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase
EC=2.7.2.1

Alternative name(s):
Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	BDI_3370

Organism

Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) [Complete proteome] [HAMAP]

Taxonomic identifier

435591 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Parabacteroides

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	Acetate kinase HAMAP MF_00020		PRO_1000002245

Sequences

	Sequence		Length	Mass (Da)
	A6LHA9 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: E545EA1C0C897BA2	FASTA	400	43,451
	10 20 30 40 50 60 MKILVLNCGS SSIKYKLFDM TSGEVMAQGG IEKIGLPGAF LKLTDKDGKK VVIEREIPGH 70 80 90 100 110 120 QEGIEFILSV LTDATYGCIK DYKEIDAVGH RVVHGGEEFA SSVLINQDVI NKVIECSDLA 130 140 150 160 170 180 PLHNPANLKG VRAMEALIPG IPQVAVFDTA FHQTMPDYAY MYGLPYEMYK KYGVRRYGFH 190 200 210 220 230 240 GTSHRYVSRR ACEILGVPYE DQKIITAHVG NGGSITAIKN GKSVDTSMGL TPVEGLLMGT 250 260 270 280 290 300 RCGDVDAGAL SFIMDKEGMD GAGLSDLINK RSGVAGLSGI SSDMREIEAA VAAGNPRAIM 310 320 330 340 350 360 TLNVYNYRIK KYIGAYAAAM GGCDILVWTG GVGENQWATR RAVCENMEYM GMKIDVEKNE 370 380 390 400 GMRGEEMVIS TPDSKVTIIV VPTDEEFMIA ADTLEILDKK

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8503 / DSM 20701 / NCTC 11152.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000140 Genomic DNA. Translation: ABR45073.1.
RefSeq	YP_001304695.1. NC_009615.1.
3D structure databases
ProteinModelPortal	A6LHA9.
SMR	A6LHA9. Positions 1-399.
ModBase	Search...
Protein-protein interaction databases
STRING	A6LHA9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5308519.
GenomeReviews	Gene locus BDI_3370 in contig CP000140_GR.
KEGG	pdi:BDI_3370.
PATRIC	22849952. VBIParDis29947_3330.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0282.
HOGENOM	HBG285863.
OMA	LIDMTNE.
ProtClustDB	PRK00180.
Enzyme and pathway databases
BioCyc	PDIS435591:BDI_3370-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_PARD8

Accession

Primary (citable) accession number: A6LHA9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program