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A6LGA2 (SYL_PARD8) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:BDI_3008
OrganismParabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) [Complete proteome] [HAMAP]
Taxonomic identifier435591 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeParabacteroides

Protein attributes

Sequence length946 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 946946Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009385

Regions

Motif40 – 5112"HIGH" region HAMAP-Rule MF_00049
Motif719 – 7235"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site7221ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A6LGA2 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 735FA3BCA5F4A5AE

FASTA946108,495
        10         20         30         40         50         60 
MEYNFREIEK KWHDYWIAEK VYKVEKDTNK PKYYVLDMFP YPSGAGLHVG HPLGYIASDI 

        70         80         90        100        110        120 
YSRFKRLQGF NVLHPMGYDA YGLPAEQYAI QTGQHPEITT KNNIARYREQ LEKIGFCYDW 

       130        140        150        160        170        180 
SREIRTCDPE YYKWTQWAFI RMFNSYYCND EKQARPISEL IQAFETSGTE GLNVACGEEL 

       190        200        210        220        230        240 
SFTAEEWKAK SDKEKQEILL NYRIAYRGET MVNWCAALGT VLANDEVVNG VSERGGYPVE 

       250        260        270        280        290        300 
QKIMRQWCLR VSAYAQRLLD GLDTIDWTDS LKETQKNWIG RSEGAEVRFK VKDSDKEFTI 

       310        320        330        340        350        360 
FTTRADTMFG VTFMVLAPES ELVQQLTTAD QKAEVDAYLD RTKKRTERER IADRQVTGVF 

       370        380        390        400        410        420 
SGSYAINPFT GEAVPIWISD YVLAGYGTGA IMAVPAHDSR DYAFAKHFGL EIRPLVEGCD 

       430        440        450        460        470        480 
VSKESFDAKE GIVCNSPRTG VTPYCDLSLN GLTIKEAIAA TKKYVKDHDL GRVKINYRLR 

       490        500        510        520        530        540 
DAIFSRQRYW GEPFPVYYDA DSMPQMLPEE CLPLLLPEVD KFLPTETGEP PLGHAVKWAW 

       550        560        570        580        590        600 
DTVNQKVTEV SKIDNQTIFP LELCTMPGFA GSSAYYLRYM DPHNDKALVA KDVDEYWRNV 

       610        620        630        640        650        660 
DLYIGGTEHA TGHLIYSRFW NKFLFDLGIV CEEEPFKKLI NQGMIQGRSN FVYRINGTNK 

       670        680        690        700        710        720 
FVSLNLKDQY EVTPIHVDVN IVSNDLLDIE AFKNWRPEYN DAEFVLEDGK YICGWAVEKM 

       730        740        750        760        770        780 
SKSMFNVVNP DMIVEKYGAD TLRLYEMFLG PLEQSKPWDT NGIDGVHRFL KKLWGLFFGN 

       790        800        810        820        830        840 
TDTLQVTDAE PTADELKSLH KLIKKVTFDI EHFSYNTSIS AFMICVNELT SLKCSKRAIL 

       850        860        870        880        890        900 
EPLITLLAPF APHIAEELWH QLGHDTTICD ARWPKHNEEY LKEKSVVYAI SFNGKARYNL 

       910        920        930        940 
ELPADISKED AEKAALNHEN SAKWMEGKTV KKVIVVPGKI VNIVVG 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000140 Genomic DNA. Translation: ABR44716.1.
RefSeqYP_001304338.1. NC_009615.1.

3D structure databases

ProteinModelPortalA6LGA2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING435591.BDI_3008.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR44716; ABR44716; BDI_3008.
GeneID5308157.
KEGGpdi:BDI_3008.
PATRIC22849218. VBIParDis29947_2967.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycPDIS435591:GCNH-3002-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_PARD8
AccessionPrimary (citable) accession number: A6LGA2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries