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A6LGA2

- SYL_PARD8

UniProt

A6LGA2 - SYL_PARD8

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei722 – 7221ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPDIS435591:GCNH-3002-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:BDI_3008
    OrganismiParabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)
    Taxonomic identifieri435591 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeParabacteroides
    ProteomesiUP000000566: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 946946Leucine--tRNA ligasePRO_1000009385Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi435591.BDI_3008.

    Structurei

    3D structure databases

    ProteinModelPortaliA6LGA2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi719 – 7235"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6LGA2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEYNFREIEK KWHDYWIAEK VYKVEKDTNK PKYYVLDMFP YPSGAGLHVG    50
    HPLGYIASDI YSRFKRLQGF NVLHPMGYDA YGLPAEQYAI QTGQHPEITT 100
    KNNIARYREQ LEKIGFCYDW SREIRTCDPE YYKWTQWAFI RMFNSYYCND 150
    EKQARPISEL IQAFETSGTE GLNVACGEEL SFTAEEWKAK SDKEKQEILL 200
    NYRIAYRGET MVNWCAALGT VLANDEVVNG VSERGGYPVE QKIMRQWCLR 250
    VSAYAQRLLD GLDTIDWTDS LKETQKNWIG RSEGAEVRFK VKDSDKEFTI 300
    FTTRADTMFG VTFMVLAPES ELVQQLTTAD QKAEVDAYLD RTKKRTERER 350
    IADRQVTGVF SGSYAINPFT GEAVPIWISD YVLAGYGTGA IMAVPAHDSR 400
    DYAFAKHFGL EIRPLVEGCD VSKESFDAKE GIVCNSPRTG VTPYCDLSLN 450
    GLTIKEAIAA TKKYVKDHDL GRVKINYRLR DAIFSRQRYW GEPFPVYYDA 500
    DSMPQMLPEE CLPLLLPEVD KFLPTETGEP PLGHAVKWAW DTVNQKVTEV 550
    SKIDNQTIFP LELCTMPGFA GSSAYYLRYM DPHNDKALVA KDVDEYWRNV 600
    DLYIGGTEHA TGHLIYSRFW NKFLFDLGIV CEEEPFKKLI NQGMIQGRSN 650
    FVYRINGTNK FVSLNLKDQY EVTPIHVDVN IVSNDLLDIE AFKNWRPEYN 700
    DAEFVLEDGK YICGWAVEKM SKSMFNVVNP DMIVEKYGAD TLRLYEMFLG 750
    PLEQSKPWDT NGIDGVHRFL KKLWGLFFGN TDTLQVTDAE PTADELKSLH 800
    KLIKKVTFDI EHFSYNTSIS AFMICVNELT SLKCSKRAIL EPLITLLAPF 850
    APHIAEELWH QLGHDTTICD ARWPKHNEEY LKEKSVVYAI SFNGKARYNL 900
    ELPADISKED AEKAALNHEN SAKWMEGKTV KKVIVVPGKI VNIVVG 946
    Length:946
    Mass (Da):108,495
    Last modified:July 24, 2007 - v1
    Checksum:i735FA3BCA5F4A5AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000140 Genomic DNA. Translation: ABR44716.1.
    RefSeqiYP_001304338.1. NC_009615.1.

    Genome annotation databases

    EnsemblBacteriaiABR44716; ABR44716; BDI_3008.
    GeneIDi5308157.
    KEGGipdi:BDI_3008.
    PATRICi22849218. VBIParDis29947_2967.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000140 Genomic DNA. Translation: ABR44716.1 .
    RefSeqi YP_001304338.1. NC_009615.1.

    3D structure databases

    ProteinModelPortali A6LGA2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 435591.BDI_3008.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR44716 ; ABR44716 ; BDI_3008 .
    GeneIDi 5308157.
    KEGGi pdi:BDI_3008.
    PATRICi 22849218. VBIParDis29947_2967.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PDIS435591:GCNH-3002-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8503 / DSM 20701 / NCTC 11152.

    Entry informationi

    Entry nameiSYL_PARD8
    AccessioniPrimary (citable) accession number: A6LGA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3