ID   A6LG40_PARD8            Unreviewed;       541 AA.
AC   A6LG40;
DT   24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   SubName: Full=Glycoside hydrolase family 33, candidate sialidase {ECO:0000313|EMBL:ABR44654.1};
GN   OrderedLocusNames=BDI_2946 {ECO:0000313|EMBL:ABR44654.1};
OS   Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM
OS   5825 / NCTC 11152).
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Tannerellaceae;
OC   Parabacteroides.
OX   NCBI_TaxID=435591 {ECO:0000313|EMBL:ABR44654.1, ECO:0000313|Proteomes:UP000000566};
RN   [1] {ECO:0000313|EMBL:ABR44654.1, ECO:0000313|Proteomes:UP000000566}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152
RC   {ECO:0000313|Proteomes:UP000000566};
RX   PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA   Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA   Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA   Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA   Knight R.D., Gordon J.I.;
RT   "Evolution of symbiotic bacteria in the distal human intestine.";
RL   PLoS Biol. 5:1574-1586(2007).
RN   [2] {ECO:0007829|PDB:4FJ6}
RP   X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 19-541.
RG   Joint Center for Structural Genomics (JCSG);
RT   "Crystal structure of a glycoside hydrolase family 33, candidate sialidase
RT   (BDI_2946) from Parabacteroides distasonis ATCC 8503 at 1.90 A
RT   resolution.";
RL   Submitted (JUN-2012) to the PDB data bank.
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DR   EMBL; CP000140; ABR44654.1; -; Genomic_DNA.
DR   RefSeq; WP_011967072.1; NC_009615.1.
DR   PDB; 4FJ6; X-ray; 1.90 A; A/B/C/D=20-541.
DR   PDBsum; 4FJ6; -.
DR   AlphaFoldDB; A6LG40; -.
DR   SMR; A6LG40; -.
DR   STRING; 435591.BDI_2946; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   PaxDb; 435591-BDI_2946; -.
DR   DNASU; 5308095; -.
DR   KEGG; pdi:BDI_2946; -.
DR   PATRIC; fig|435591.13.peg.2908; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_024620_0_0_10; -.
DR   BioCyc; PDIS435591:G1G5A-3023-MONOMER; -.
DR   Proteomes; UP000000566; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.40.1290; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR029456; Sialidase_N.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF19; SIALIDASE; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   Pfam; PF14873; BNR_assoc_N; 1.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:4FJ6};
KW   Hydrolase {ECO:0000313|EMBL:ABR44654.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000566};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..541
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002699286"
FT   DOMAIN          20..169
FT                   /note="Sialidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14873"
FT   DOMAIN          201..481
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
SQ   SEQUENCE   541 AA;  60191 MW;  0EBE5CECA9F394CD CRC64;
     MKKTFLYFCL LFIVQTAFAA DSIYVREQQI PILIDRIDNV LYEMRIPAQK GDVLNEITIQ
     IGDNVDLSDI QAIRLFYSGV EAPSRKGEHF SPVTYISSHI PGNTRKALES YSVRQDEVTA
     PLSRTVKLTS KQPMLKGINY FWVSIQMKPE TSLLAKVATT MPNAQINNKP INITWKGKVD
     ERHVGIGVRQ AGDDGSAAFR IPGLVTTNNG TLLGVYDIRY NSSVDLQEKI DIGVSRSTDK
     GQTWEPMRVA MTFKQTDGLP HGQNGVGDPS ILVDEKTNTI WVVAAWTHGM GNERAWWNSM
     PGMTPDETAQ LMLVKSEDDG KTWSEPINIT SQVKDPSWYF LLQGPGRGIT MQDGTLVFPI
     QFIDATRVPN AGIMYSKDRG KTWHLHNLAR TNTTEAQVAE VEPGVLMLNM RDNRGGSRAV
     ATTKDLGKTW TEHPSSRSAL QESVCMASLI KVNAKDNITG KDLLLFSNPN TTKGRNHITI
     KASLDGGLTW PTEHQVLLDE AEGWGYSCLS MIDKETVGIF YESSVAHMTF QAVKLQDLIH
     Q
//