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A6LG40

- A6LG40_PARD8

UniProt

A6LG40 - A6LG40_PARD8

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Protein
Submitted name:

Glycoside hydrolase family 33, candidate sialidase

Gene

BDI_2946

Organism
Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei26 – 261Phosphate 1Imported
Binding sitei200 – 2001Phosphate 2Imported
Binding sitei236 – 2361Phosphate 4Imported
Binding sitei236 – 2361Phosphate 5Imported
Binding sitei245 – 2451Phosphate 5Imported
Binding sitei261 – 2611Phosphate 3Imported
Binding sitei321 – 3211Phosphate 4Imported
Binding sitei321 – 3211Phosphate 5Imported
Binding sitei384 – 3841Phosphate 6Imported
Binding sitei411 – 4111Phosphate 2Imported
Binding sitei475 – 4751Phosphate 2Imported
Binding sitei506 – 5061Phosphate 2Imported

GO - Molecular functioni

  1. exo-alpha-sialidase activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Enzyme and pathway databases

BioCyciPDIS435591:GCNH-2940-MONOMER.

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
Glycoside hydrolase family 33, candidate sialidaseImported
Gene namesi
Ordered Locus Names:BDI_2946Imported
OrganismiParabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)Imported
Taxonomic identifieri435591 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeParabacteroides
ProteomesiUP000000566: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi435591.BDI_2946.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FJ6X-ray1.90A/B/C/D20-541[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni89 – 902Phosphate 1 bindingImported

Phylogenomic databases

eggNOGiCOG4409.
HOGENOMiHOG000252336.
KOiK01186.
OMAiLNMRDDR.
OrthoDBiEOG67DPK3.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR029456. Sialidase_N.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF14873. BNR_assoc_N. 1 hit.
[Graphical view]
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

A6LG40-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKTFLYFCL LFIVQTAFAA DSIYVREQQI PILIDRIDNV LYEMRIPAQK
60 70 80 90 100
GDVLNEITIQ IGDNVDLSDI QAIRLFYSGV EAPSRKGEHF SPVTYISSHI
110 120 130 140 150
PGNTRKALES YSVRQDEVTA PLSRTVKLTS KQPMLKGINY FWVSIQMKPE
160 170 180 190 200
TSLLAKVATT MPNAQINNKP INITWKGKVD ERHVGIGVRQ AGDDGSAAFR
210 220 230 240 250
IPGLVTTNNG TLLGVYDIRY NSSVDLQEKI DIGVSRSTDK GQTWEPMRVA
260 270 280 290 300
MTFKQTDGLP HGQNGVGDPS ILVDEKTNTI WVVAAWTHGM GNERAWWNSM
310 320 330 340 350
PGMTPDETAQ LMLVKSEDDG KTWSEPINIT SQVKDPSWYF LLQGPGRGIT
360 370 380 390 400
MQDGTLVFPI QFIDATRVPN AGIMYSKDRG KTWHLHNLAR TNTTEAQVAE
410 420 430 440 450
VEPGVLMLNM RDNRGGSRAV ATTKDLGKTW TEHPSSRSAL QESVCMASLI
460 470 480 490 500
KVNAKDNITG KDLLLFSNPN TTKGRNHITI KASLDGGLTW PTEHQVLLDE
510 520 530 540
AEGWGYSCLS MIDKETVGIF YESSVAHMTF QAVKLQDLIH Q
Length:541
Mass (Da):60,191
Last modified:July 24, 2007 - v1
Checksum:i0EBE5CECA9F394CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000140 Genomic DNA. Translation: ABR44654.1.
RefSeqiYP_001304276.1. NC_009615.1.

Genome annotation databases

EnsemblBacteriaiABR44654; ABR44654; BDI_2946.
GeneIDi5308095.
KEGGipdi:BDI_2946.
PATRICi22849100. VBIParDis29947_2908.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000140 Genomic DNA. Translation: ABR44654.1 .
RefSeqi YP_001304276.1. NC_009615.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4FJ6 X-ray 1.90 A/B/C/D 20-541 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 435591.BDI_2946.

Protein family/group databases

CAZyi GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR44654 ; ABR44654 ; BDI_2946 .
GeneIDi 5308095.
KEGGi pdi:BDI_2946.
PATRICi 22849100. VBIParDis29947_2908.

Phylogenomic databases

eggNOGi COG4409.
HOGENOMi HOG000252336.
KOi K01186.
OMAi LNMRDDR.
OrthoDBi EOG67DPK3.

Enzyme and pathway databases

BioCyci PDIS435591:GCNH-2940-MONOMER.

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR026856. Sialidase_fam.
IPR029456. Sialidase_N.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view ]
PANTHERi PTHR10628. PTHR10628. 1 hit.
Pfami PF14873. BNR_assoc_N. 1 hit.
[Graphical view ]
PRINTSi PR01803. TCSIALIDASE.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8503 / DSM 20701 / NCTC 11152Imported.
  2. "Crystal structure of a glycoside hydrolase family 33, candidate sialidase (BDI_2946) from Parabacteroides distasonis ATCC 8503 at 1.90 A resolution."
    JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG)
    Submitted (JUN-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 20-541.

Entry informationi

Entry nameiA6LG40_PARD8
AccessioniPrimary (citable) accession number: A6LG40
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: October 1, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3