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A6LG40

- A6LG40_PARD8

UniProt

A6LG40 - A6LG40_PARD8

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Protein
Submitted name: Glycoside hydrolase family 33, candidate sialidase
Gene
BDI_2946
Organism
Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei26 – 261Phosphate 1Imported
Binding sitei200 – 2001Phosphate 2Imported
Binding sitei236 – 2361Phosphate 4Imported
Binding sitei236 – 2361Phosphate 5Imported
Binding sitei245 – 2451Phosphate 5Imported
Binding sitei261 – 2611Phosphate 3Imported
Binding sitei321 – 3211Phosphate 4Imported
Binding sitei321 – 3211Phosphate 5Imported
Binding sitei384 – 3841Phosphate 6Imported
Binding sitei411 – 4111Phosphate 2Imported
Binding sitei475 – 4751Phosphate 2Imported
Binding sitei506 – 5061Phosphate 2Imported

GO - Molecular functioni

  1. exo-alpha-sialidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseImported

Enzyme and pathway databases

BioCyciPDIS435591:GCNH-2940-MONOMER.

Protein family/group databases

CAZyiGH33. Glycoside Hydrolase Family 33.

Names & Taxonomyi

Protein namesi
Submitted name:
Glycoside hydrolase family 33, candidate sialidaseImported
Gene namesi
Ordered Locus Names:BDI_2946Imported
OrganismiParabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)Imported
Taxonomic identifieri435591 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeParabacteroides
ProteomesiUP000000566: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi435591.BDI_2946.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FJ6X-ray1.90A/B/C/D20-541[»]

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni89 – 902Phosphate 1 bindingImported

Phylogenomic databases

eggNOGiCOG4409.
HOGENOMiHOG000252336.
KOiK01186.
OMAiLNMRDDR.
OrthoDBiEOG67DPK3.

Family and domain databases

Gene3Di2.120.10.10. 1 hit.
InterProiIPR026856. Sialidase_fam.
IPR029456. Sialidase_N.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view]
PANTHERiPTHR10628. PTHR10628. 1 hit.
PfamiPF14873. BNR_assoc_N. 1 hit.
[Graphical view]
PRINTSiPR01803. TCSIALIDASE.
SUPFAMiSSF50939. SSF50939. 1 hit.

Sequencei

Sequence statusi: Complete.

A6LG40-1 [UniParc]FASTAAdd to Basket

« Hide

MKKTFLYFCL LFIVQTAFAA DSIYVREQQI PILIDRIDNV LYEMRIPAQK    50
GDVLNEITIQ IGDNVDLSDI QAIRLFYSGV EAPSRKGEHF SPVTYISSHI 100
PGNTRKALES YSVRQDEVTA PLSRTVKLTS KQPMLKGINY FWVSIQMKPE 150
TSLLAKVATT MPNAQINNKP INITWKGKVD ERHVGIGVRQ AGDDGSAAFR 200
IPGLVTTNNG TLLGVYDIRY NSSVDLQEKI DIGVSRSTDK GQTWEPMRVA 250
MTFKQTDGLP HGQNGVGDPS ILVDEKTNTI WVVAAWTHGM GNERAWWNSM 300
PGMTPDETAQ LMLVKSEDDG KTWSEPINIT SQVKDPSWYF LLQGPGRGIT 350
MQDGTLVFPI QFIDATRVPN AGIMYSKDRG KTWHLHNLAR TNTTEAQVAE 400
VEPGVLMLNM RDNRGGSRAV ATTKDLGKTW TEHPSSRSAL QESVCMASLI 450
KVNAKDNITG KDLLLFSNPN TTKGRNHITI KASLDGGLTW PTEHQVLLDE 500
AEGWGYSCLS MIDKETVGIF YESSVAHMTF QAVKLQDLIH Q 541
Length:541
Mass (Da):60,191
Last modified:July 24, 2007 - v1
Checksum:i0EBE5CECA9F394CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000140 Genomic DNA. Translation: ABR44654.1.
RefSeqiYP_001304276.1. NC_009615.1.

Genome annotation databases

EnsemblBacteriaiABR44654; ABR44654; BDI_2946.
GeneIDi5308095.
KEGGipdi:BDI_2946.
PATRICi22849100. VBIParDis29947_2908.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000140 Genomic DNA. Translation: ABR44654.1 .
RefSeqi YP_001304276.1. NC_009615.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4FJ6 X-ray 1.90 A/B/C/D 20-541 [» ]
ModBasei Search...

Protein-protein interaction databases

STRINGi 435591.BDI_2946.

Protein family/group databases

CAZyi GH33. Glycoside Hydrolase Family 33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR44654 ; ABR44654 ; BDI_2946 .
GeneIDi 5308095.
KEGGi pdi:BDI_2946.
PATRICi 22849100. VBIParDis29947_2908.

Phylogenomic databases

eggNOGi COG4409.
HOGENOMi HOG000252336.
KOi K01186.
OMAi LNMRDDR.
OrthoDBi EOG67DPK3.

Enzyme and pathway databases

BioCyci PDIS435591:GCNH-2940-MONOMER.

Family and domain databases

Gene3Di 2.120.10.10. 1 hit.
InterProi IPR026856. Sialidase_fam.
IPR029456. Sialidase_N.
IPR008377. Sialidase_trypan.
IPR011040. Sialidases.
[Graphical view ]
PANTHERi PTHR10628. PTHR10628. 1 hit.
Pfami PF14873. BNR_assoc_N. 1 hit.
[Graphical view ]
PRINTSi PR01803. TCSIALIDASE.
SUPFAMi SSF50939. SSF50939. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8503 / DSM 20701 / NCTC 11152.
  2. "Crystal structure of a glycoside hydrolase family 33, candidate sialidase (BDI_2946) from Parabacteroides distasonis ATCC 8503 at 1.90 A resolution."
    JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG)
    Submitted (JUN-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 20-541 IN COMPLEX WITH PHOSPHATE.

Entry informationi

Entry nameiA6LG40_PARD8
AccessioniPrimary (citable) accession number: A6LG40
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: September 3, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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