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A6LG40

- A6LG40_PARD8

UniProt

A6LG40 - A6LG40_PARD8

Protein
Submitted name:

Glycoside hydrolase family 33, candidate sialidase

Gene

BDI_2946

Organism
Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei26 – 261Phosphate 1Imported
    Binding sitei200 – 2001Phosphate 2Imported
    Binding sitei236 – 2361Phosphate 4Imported
    Binding sitei236 – 2361Phosphate 5Imported
    Binding sitei245 – 2451Phosphate 5Imported
    Binding sitei261 – 2611Phosphate 3Imported
    Binding sitei321 – 3211Phosphate 4Imported
    Binding sitei321 – 3211Phosphate 5Imported
    Binding sitei384 – 3841Phosphate 6Imported
    Binding sitei411 – 4111Phosphate 2Imported
    Binding sitei475 – 4751Phosphate 2Imported
    Binding sitei506 – 5061Phosphate 2Imported

    GO - Molecular functioni

    1. exo-alpha-sialidase activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Keywords - Molecular functioni

    HydrolaseImported

    Enzyme and pathway databases

    BioCyciPDIS435591:GCNH-2940-MONOMER.

    Protein family/group databases

    CAZyiGH33. Glycoside Hydrolase Family 33.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Glycoside hydrolase family 33, candidate sialidaseImported
    Gene namesi
    Ordered Locus Names:BDI_2946Imported
    OrganismiParabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)Imported
    Taxonomic identifieri435591 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeParabacteroides
    ProteomesiUP000000566: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi435591.BDI_2946.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4FJ6X-ray1.90A/B/C/D20-541[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni89 – 902Phosphate 1 bindingImported

    Phylogenomic databases

    eggNOGiCOG4409.
    HOGENOMiHOG000252336.
    KOiK01186.
    OMAiLNMRDDR.
    OrthoDBiEOG67DPK3.

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR026856. Sialidase_fam.
    IPR029456. Sialidase_N.
    IPR008377. Sialidase_trypan.
    IPR011040. Sialidases.
    [Graphical view]
    PANTHERiPTHR10628. PTHR10628. 1 hit.
    PfamiPF14873. BNR_assoc_N. 1 hit.
    [Graphical view]
    PRINTSiPR01803. TCSIALIDASE.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6LG40-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKTFLYFCL LFIVQTAFAA DSIYVREQQI PILIDRIDNV LYEMRIPAQK    50
    GDVLNEITIQ IGDNVDLSDI QAIRLFYSGV EAPSRKGEHF SPVTYISSHI 100
    PGNTRKALES YSVRQDEVTA PLSRTVKLTS KQPMLKGINY FWVSIQMKPE 150
    TSLLAKVATT MPNAQINNKP INITWKGKVD ERHVGIGVRQ AGDDGSAAFR 200
    IPGLVTTNNG TLLGVYDIRY NSSVDLQEKI DIGVSRSTDK GQTWEPMRVA 250
    MTFKQTDGLP HGQNGVGDPS ILVDEKTNTI WVVAAWTHGM GNERAWWNSM 300
    PGMTPDETAQ LMLVKSEDDG KTWSEPINIT SQVKDPSWYF LLQGPGRGIT 350
    MQDGTLVFPI QFIDATRVPN AGIMYSKDRG KTWHLHNLAR TNTTEAQVAE 400
    VEPGVLMLNM RDNRGGSRAV ATTKDLGKTW TEHPSSRSAL QESVCMASLI 450
    KVNAKDNITG KDLLLFSNPN TTKGRNHITI KASLDGGLTW PTEHQVLLDE 500
    AEGWGYSCLS MIDKETVGIF YESSVAHMTF QAVKLQDLIH Q 541
    Length:541
    Mass (Da):60,191
    Last modified:July 24, 2007 - v1
    Checksum:i0EBE5CECA9F394CD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000140 Genomic DNA. Translation: ABR44654.1.
    RefSeqiYP_001304276.1. NC_009615.1.

    Genome annotation databases

    EnsemblBacteriaiABR44654; ABR44654; BDI_2946.
    GeneIDi5308095.
    KEGGipdi:BDI_2946.
    PATRICi22849100. VBIParDis29947_2908.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000140 Genomic DNA. Translation: ABR44654.1 .
    RefSeqi YP_001304276.1. NC_009615.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4FJ6 X-ray 1.90 A/B/C/D 20-541 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 435591.BDI_2946.

    Protein family/group databases

    CAZyi GH33. Glycoside Hydrolase Family 33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR44654 ; ABR44654 ; BDI_2946 .
    GeneIDi 5308095.
    KEGGi pdi:BDI_2946.
    PATRICi 22849100. VBIParDis29947_2908.

    Phylogenomic databases

    eggNOGi COG4409.
    HOGENOMi HOG000252336.
    KOi K01186.
    OMAi LNMRDDR.
    OrthoDBi EOG67DPK3.

    Enzyme and pathway databases

    BioCyci PDIS435591:GCNH-2940-MONOMER.

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR026856. Sialidase_fam.
    IPR029456. Sialidase_N.
    IPR008377. Sialidase_trypan.
    IPR011040. Sialidases.
    [Graphical view ]
    PANTHERi PTHR10628. PTHR10628. 1 hit.
    Pfami PF14873. BNR_assoc_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01803. TCSIALIDASE.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8503 / DSM 20701 / NCTC 11152Imported.
    2. "Crystal structure of a glycoside hydrolase family 33, candidate sialidase (BDI_2946) from Parabacteroides distasonis ATCC 8503 at 1.90 A resolution."
      JOINT CENTER FOR STRUCTURAL GENOMICS (JCSG)
      Submitted (JUN-2012) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 20-541.

    Entry informationi

    Entry nameiA6LG40_PARD8
    AccessioniPrimary (citable) accession number: A6LG40
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 24, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3