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A6LFE8 (GCH1_PARD8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:BDI_2693
OrganismParabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) [Complete proteome] [HAMAP]
Taxonomic identifier435591 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeParabacteroides

Protein attributes

Sequence length196 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 196196GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_1000043715

Sites

Metal binding861Zinc By similarity
Metal binding891Zinc By similarity
Metal binding1571Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
A6LFE8 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 96B38256AAFA7407

FASTA19622,802
        10         20         30         40         50         60 
MSEVNEETLR AREALAGHYK EVLGLLGEDV EREGLLKTPE RVAKAMQFLT KGYHEDPEAV 

        70         80         90        100        110        120 
LRSAMFQEED YKQMVIVKDI DFFSLCEHHM LPFFGKAHVA YIPKKYITGL SKIPRVVDIF 

       130        140        150        160        170        180 
ARRLQIQERM TMQIKDCIQR TLDPLGVMVV IEAQHMCMQM RGVEKQNSLT TTSDFTGFFQ 

       190 
QAKTREEFMN LIKHNR 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000140 Genomic DNA. Translation: ABR44412.1.
RefSeqYP_001304034.1. NC_009615.1.

3D structure databases

ProteinModelPortalA6LFE8.
SMRA6LFE8. Positions 12-194.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING435591.BDI_2693.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR44412; ABR44412; BDI_2693.
GeneID5307842.
KEGGpdi:BDI_2693.
PATRIC22848602. VBIParDis29947_2670.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAFTEWLAD.
OrthoDBEOG6XHC8G.
ProtClustDBPRK09347.

Enzyme and pathway databases

BioCycPDIS435591:GCNH-2687-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_PARD8
AccessionPrimary (citable) accession number: A6LFE8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways