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Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase 1 (folE)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi86ZincUniRule annotation1
Metal bindingi89ZincUniRule annotation1
Metal bindingi157ZincUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandGTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IUniRule annotation
Short name:
GTP-CH-IUniRule annotation
Gene namesi
Name:folEUniRule annotation
Ordered Locus Names:BDI_2693
OrganismiParabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)
Taxonomic identifieri435591 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesTannerellaceaeParabacteroides
Proteomesi
  • UP000000566 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000437151 – 196GTP cyclohydrolase 1Add BLAST196

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers.By similarity

Protein-protein interaction databases

STRINGi435591.BDI_2693.

Structurei

3D structure databases

ProteinModelPortaliA6LFE8.
SMRiA6LFE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase I family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EUJ. Bacteria.
COG0302. LUCA.
HOGENOMiHOG000221222.
KOiK01495.
OMAiIVVVECE.
OrthoDBiPOG091H01SE.

Family and domain databases

HAMAPiMF_00223. FolE. 1 hit.
InterProiView protein in InterPro
IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiView protein in Pfam
PF01227. GTP_cyclohydroI. 1 hit.
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiView protein in PROSITE
PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A6LFE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEVNEETLR AREALAGHYK EVLGLLGEDV EREGLLKTPE RVAKAMQFLT
60 70 80 90 100
KGYHEDPEAV LRSAMFQEED YKQMVIVKDI DFFSLCEHHM LPFFGKAHVA
110 120 130 140 150
YIPKKYITGL SKIPRVVDIF ARRLQIQERM TMQIKDCIQR TLDPLGVMVV
160 170 180 190
IEAQHMCMQM RGVEKQNSLT TTSDFTGFFQ QAKTREEFMN LIKHNR
Length:196
Mass (Da):22,802
Last modified:July 24, 2007 - v1
Checksum:i96B38256AAFA7407
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000140 Genomic DNA. Translation: ABR44412.1.
RefSeqiWP_005860986.1. NC_009615.1.

Genome annotation databases

EnsemblBacteriaiABR44412; ABR44412; BDI_2693.
GeneIDi5307842.
KEGGipdi:BDI_2693.

Similar proteinsi

Entry informationi

Entry nameiGCH1_PARD8
AccessioniPrimary (citable) accession number: A6LFE8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: August 30, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families