Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

A6LFD0 (DDL_PARD8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:BDI_2675
OrganismParabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) [Complete proteome] [HAMAP]
Taxonomic identifier435591 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeParabacteroides

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341143

Regions

Domain121 – 321201ATP-grasp
Nucleotide binding149 – 20456ATP By similarity

Sites

Metal binding2751Magnesium or manganese 1 By similarity
Metal binding2881Magnesium or manganese 1 By similarity
Metal binding2881Magnesium or manganese 2 By similarity
Metal binding2901Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
A6LFD0 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 106F853140EC70B0

FASTA33036,498
        10         20         30         40         50         60 
MKKNIAIVAG GDSSEIVISL KSADGIYSFI DKDKYNLYIA IVKRDEWAVI LPSGEHTPID 

        70         80         90        100        110        120 
KNDFSFKENG VTRHFDFAYI TIHGTPGEDG RLQGYFDMIG MPYSSCGMLV SALTFNKYVC 

       130        140        150        160        170        180 
NHYLKDFGVK IAASIHLFKG ETITDEEVVT RLGLPIFVKP NDGGSSFGVT KVKEVSAIQP 

       190        200        210        220        230        240 
AIAKAFGEGR EVILERFIDG TEVTCGCYKV EGKEVVFPLT EVVTNNEFFD FDAKYNGQVD 

       250        260        270        280        290        300 
EITPARISTE LTELIQCETS RIYDILGAKG LIRVDYIIPA DGEPVLLEIN TTPGMTATSF 

       310        320        330 
IPQQVRAAGL DIKDVMTDII EDELKNRKTK 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000140 Genomic DNA. Translation: ABR44394.1.
RefSeqYP_001304016.1. NC_009615.1.

3D structure databases

ProteinModelPortalA6LFD0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING435591.BDI_2675.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR44394; ABR44394; BDI_2675.
GeneID5307824.
KEGGpdi:BDI_2675.
PATRIC22848566. VBIParDis29947_2652.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMACSGYSRV.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycPDIS435591:GCNH-2669-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_PARD8
AccessionPrimary (citable) accession number: A6LFD0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 24, 2007
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways