A6LF91 (A6LF91_PARD8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Glycosyltransferase family 19, candidate lipid-alpha-disaccharide synthase EMBL ABR44355.1

Gene names

Ordered Locus Names:

BDI_2636

Organism

Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) [Complete proteome] [HAMAP]

Taxonomic identifier

435591 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Parabacteroides

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A6LF91 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: BD87219DDB94F976	FASTA	377	42,879
	10 20 30 40 50 60 MKYYLIAGEA SGDLHASNLM AALKENDPKA EFRFLGGDLM RAVGGTLVKH YREMAFMGFI 70 80 90 100 110 120 PVLLNLRTIL NNMKTCQEDI RRYQPDVVIL IDYPGFNLKI AKYVKTQLGL PVYYYISPKI 130 140 150 160 170 180 WAWKQYRIRD FRRYVDRMFC ILPFETEFFR KLNYSVDYVG NPSVDSVAYY KEHQAIPKDT 190 200 210 220 230 240 FIKEEGLANK PILALLSGSR KQEIKDNLPT MLKVASAYPD YQPVIAGAPG IDPAYYQEYI 250 260 270 280 290 300 GSYPAKIVFG KTYPLLQHSA AALVTSGTAT LETALFRVPQ VVCYYVVAGQ LASFIFKHFF 310 320 330 340 350 360 HTKYISLVNL IGGREIVQEL FGARFSESQI QDELGRILQD PAYRKRMLDG YDKIIHTLGM 370 PGASKRTARL IVESLGS

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000140 Genomic DNA. Translation: ABR44355.1.
RefSeq	YP_001303977.1. NC_009615.1.
3D structure databases
ProteinModelPortal	A6LF91.
ModBase	Search...
Protein-protein interaction databases
STRING	A6LF91.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5307785.
GenomeReviews	Gene locus BDI_2636 in contig CP000140_GR.
KEGG	pdi:BDI_2636.
PATRIC	22848486. VBIParDis29947_2612.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HBG584837.
OMA	IGLANIM.
ProtClustDB	CLSK2391382.
Enzyme and pathway databases
BioCyc	PDIS435591:BDI_2636-MONOMER.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A6LF91_PARD8

Accession

Primary (citable) accession number: A6LF91

Entry history

Integrated into UniProtKB/TrEMBL:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)