A6LF90 (SURE_PARD8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	BDI_2635

Organism

Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) [Complete proteome] [HAMAP]

Taxonomic identifier

435591 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Parabacteroides

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 255	255	5'-nucleotidase surE HAMAP MF_00060		PRO_1000007756
Sites
	Metal binding	13	1	Divalent metal cation By similarity
	Metal binding	14	1	Divalent metal cation By similarity
	Metal binding	44	1	Divalent metal cation By similarity
	Metal binding	100	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6LF90 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 9E6DD9EF3EA1EC01	FASTA	255	27,746
	10 20 30 40 50 60 MTNERPLILI TNDDGVWAKG INELIECLKD LGDLVVFAPD GPRSGMGSAI TSLVPIKYTL 70 80 90 100 110 120 LKKEEGLTIY SCTGTPVDCV KLAINEVLER KPDLLVSGIN HGGNMAICVN YSGTMGAAAE 130 140 150 160 170 180 GCIFNVPSMG VSLLDHAADA DFSECCRLGR MLARRVLKEG LPHGTYLNLN VPKLPQVKGL 190 200 210 220 230 240 KVCRQADGRW VREFKRSENA SGEPVFWLTG AFESAKPIHP DNDMLALDSG YASLVPCKID 250 VTDYDFMATL NNWIL

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8503 / DSM 20701 / NCTC 11152.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000140 Genomic DNA. Translation: ABR44354.1.
RefSeq	YP_001303976.1. NC_009615.1.
3D structure databases
ProteinModelPortal	A6LF90.
ModBase	Search...
Protein-protein interaction databases
STRING	A6LF90.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5307784.
GenomeReviews	Gene locus BDI_2635 in contig CP000140_GR.
KEGG	pdi:BDI_2635.
PATRIC	22848484. VBIParDis29947_2611.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0496.
HOGENOM	HBG600532.
OMA	DCVKMGI.
ProtClustDB	PRK00346.
Enzyme and pathway databases
BioCyc	PDIS435591:BDI_2635-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_PARD8

Accession

Primary (citable) accession number: A6LF90

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program