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A6LEU5 (A6LEU5_PARD8) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP MF_00639 RuleBase RU003664
EC=6.3.2.9 HAMAP MF_00639 RuleBase RU003664
Alternative name(s):
D-glutamic acid-adding enzyme HAMAP MF_00639
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase HAMAP MF_00639
Gene names
Name:murD HAMAP MF_00639
Ordered Locus Names:BDI_2489
OrganismParabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) [Complete proteome] [HAMAP]
Taxonomic identifier435591 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Parabacteroides

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Subcellular location

Cytoplasm By similarity HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762.

Sequence similarities

Belongs to the MurCDEF family. HAMAP MF_00639 RuleBase RU003630

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding110 – 1167ATP By similarity HAMAP MF_00639

Sequences

Sequence LengthMass (Da)Tools
A6LEU5 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 9EF662082FDFCC08

FASTA44549,355
        10         20         30         40         50         60 
MSKRMVILGA GESGAGAAVL AKAKGFDVFV SDKSSIKPKY KEMLDNHGIR WEEGQHTEAD 

        70         80         90        100        110        120 
ILNADEIVKS PGIPDKAPII QLLKKQGTPI ISEIEFAGRY TDSKMICITG SNGKTTTTML 

       130        140        150        160        170        180 
TYHILKEAGV DVGLAGNVGN SLALQVAEDP HAVYVIELSS FQLDNMYDFK ADIAIILNIT 

       190        200        210        220        230        240 
PDHLDRYNYE MQNYVDAKFR ILQNQTKDDA FIFWNDDPII AREIAKRHPE ATLYPFAETH 

       250        260        270        280        290        300 
ENGMKGYTEN NQVVIETANG TFTMEQDLLA LTGTHNLYNS LASGIASKIV DIHDEKIRAS 

       310        320        330        340        350        360 
LSDFTGVEHR LEKVLRVRGV DYINDSKATN VNSCWYALQS MTTPVVLILG GTDKGNDYSE 

       370        380        390        400        410        420 
IEELVSKKVH SLIFMGVDNT KLHAFFDGKV ANIEDARSME EAVAKAYKMA HKGDTVLLSP 

       430        440 
CCASFDLFKS YEDRGDQFKA CVRNL

« Hide

References

[1]"Evolution of symbiotic bacteria in the distal human intestine."
Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I.
PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000140 Genomic DNA. Translation: ABR44209.1.
RefSeqYP_001303831.1. NC_009615.1.

3D structure databases

ProteinModelPortalA6LEU5.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6LEU5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5307638.
GenomeReviewsGene locus BDI_2489 in contig CP000140_GR.
KEGGpdi:BDI_2489.
PATRIC22848204. VBIParDis29947_2472.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0771.
HOGENOMHBG750024.
OMAACASWDM.

Enzyme and pathway databases

BioCycPDIS435591:BDI_2489-MONOMER.

Family and domain databases

HAMAPMF_00639. MurD.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01925.
PANTHERPTHR23135:SF2. PTHR23135:SF2. 1 hit.
PfamPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01087. MurD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA6LEU5_PARD8
AccessionPrimary (citable) accession number: A6LEU5
Entry history
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info