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A6LEL8 (UPPP_PARD8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:BDI_2407
OrganismParabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) [Complete proteome] [HAMAP]
Taxonomic identifier435591 [NCBI]
Taxonomic lineageBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeParabacteroides

Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 266266Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000303032

Regions

Transmembrane41 – 6121Helical; Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane107 – 12721Helical; Potential
Transmembrane140 – 16021Helical; Potential
Transmembrane180 – 20021Helical; Potential
Transmembrane213 – 23321Helical; Potential
Transmembrane245 – 26521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A6LEL8 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 25771B7C03967631

FASTA26628,577
        10         20         30         40         50         60 
MSWFEALILG IVQGLTEYLP VSSSGHLAIG SALFGIEGEE NLAFTIVVHV ATVFSTLVVL 

        70         80         90        100        110        120 
WKEIDWIFRG LFKFQMNAET KYVINILISM IPIGIVGVFF KDTVEQIFGS GLLVVGCMLL 

       130        140        150        160        170        180 
LTAALLAFSY YAKPRQKESI SMKDAFIIGL AQACAVMPGL SRSGSTIATG LLLGNNKAKL 

       190        200        210        220        230        240 
AQFSFLMVIP PILGEALLDV MKMVKGEDVA GDIPALSLAV GFMAAFVSGC VACKWMINIV 

       250        260 
KKGKLIYFAI YCAIAGLVTI ACTLLK 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000140 Genomic DNA. Translation: ABR44132.1.
RefSeqYP_001303754.1. NC_009615.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING435591.BDI_2407.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR44132; ABR44132; BDI_2407.
GeneID5307556.
KEGGpdi:BDI_2407.
PATRIC22848038. VBIParDis29947_2394.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBCLSK823439.

Enzyme and pathway databases

BioCycPDIS435591:GCNH-2401-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_PARD8
AccessionPrimary (citable) accession number: A6LEL8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 24, 2007
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families