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A6LCZ1 (GLPK_PARD8) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:BDI_1816
OrganismParabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) [Complete proteome] [HAMAP]
Taxonomic identifier435591 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Parabacteroides

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 499499Glycerol kinase HAMAP MF_00186
PRO_1000058455

Regions

Nucleotide binding412 – 4165ATP By similarity

Sites

Binding site151Substrate By similarity
Binding site191ATP By similarity
Binding site851Substrate By similarity
Binding site1371Substrate By similarity
Binding site2461Substrate By similarity
Binding site2681ATP By similarity
Binding site3111ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
A6LCZ1 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 1DDD22626F6DCE38

FASTA49955,778
        10         20         30         40         50         60 
MNFRNKYVLA IDQGTTSSRA ILFNHQGTII TLAQKPFQQY FPKPGWVEHD PNEIWYTQSS 

        70         80         90        100        110        120 
VIKEAMAKAD VTDSHIACIG IANQRETTII WDRETGFPVY NAIVWQDRRT ADYCEELKSQ 

       130        140        150        160        170        180 
GWAERILQKT GLVIDAYFSA TKIKWILDNV KGIRERAERG ELCFGTVDTW LVWKLTRGAQ 

       190        200        210        220        230        240 
FITDVTNASR TMLFNIRTLQ WDQELLDLFT IPASMLPQVK ACSEVYCETS TPIFKKGIPV 

       250        260        270        280        290        300 
SGMAGDQQAA LFGQLCVEDG MIKTTYGTGC FMILNTGKEP VLSQNNLLTT IAWKLGDQTT 

       310        320        330        340        350        360 
YALEGSVFVG GAVVQWLRDG IGLIPNASIT EQMAKSVSDN GGVYFVPALT GLGAPYWDQY 

       370        380        390        400        410        420 
ARGAIIGITR GTTAAHLTRA ALEGICYQVY DVLMAMENDI HAKPKEIRVD GGAIANNFLM 

       430        440        450        460        470        480 
QFQSDICRCP VVRPNVLETT ALGAAYLAGL AIGYWKDIDE LKEQWCLDKV FNPQMKEDTA 

       490 
RKLLNEWHKA VGRSQNWAE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000140 Genomic DNA. Translation: ABR43555.1.
RefSeqYP_001303177.1. NC_009615.1.

3D structure databases

ProteinModelPortalA6LCZ1.
SMRA6LCZ1. Positions 5-499.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6LCZ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5306966.
GenomeReviewsGene locus BDI_1816 in contig CP000140_GR.
KEGGpdi:BDI_1816.
PATRIC22846832. VBIParDis29947_1803.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0554.
HOGENOMHBG511469.
OMAALYGQLC.

Enzyme and pathway databases

BioCycPDIS435591:BDI_1816-MONOMER.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_PARD8
AccessionPrimary (citable) accession number: A6LCZ1
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 24, 2007
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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