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A6LAR6

- FTHS_PARD8

UniProt

A6LAR6 - FTHS_PARD8

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 718ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPDIS435591:GCNH-1012-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:BDI_1014
    OrganismiParabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)
    Taxonomic identifieri435591 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeParabacteroides
    ProteomesiUP000000566: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_0000300533Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi435591.BDI_1014.

    Structurei

    3D structure databases

    ProteinModelPortaliA6LAR6.
    SMRiA6LAR6. Positions 4-553.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6LAR6-1 [UniParc]FASTAAdd to Basket

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    MKSDIEIARE TDLRKIKEVA TTLGIPREEV QNYGRYIAKV PIHLIDKKQM    50
    DQHNLILVTA ITPTKAGIGK TTVSIGLALG LNKIGKKAVV ALREPSLGPC 100
    FGMKGGAAGG GYAQVLPMEN INLHFTGDFH AVTSAHNMIT ALLDNYIYQT 150
    RNTCEGLKEI KWKRVLDVND RSLRNIVSGL GGSANGVPTE TGFDITPASE 200
    IMAILCLATD IEDLKRRVGN ILLGYTNEDK PFTVNDLGIA GAITVLLKDA 250
    LLPNLVQTTE NTPAFVHGGP FANIAHGCNS ISATQMALTY GDYVITEAGF 300
    GADLGAEKFF NIKCRKAGLS PKLTVIVATA QSLKLHGGVP EKEIKEPNIE 350
    GLKNGFANLD KHIENMKSFG QQVIVTFNRF ATDTDEEIAL VAEHCEEKGV 400
    GFAMNNVFAE GGEGGTELAR LVVDTIENHP SAPLQYTYDL NDPIRTKVQK 450
    VAQKIYGASS IVYTTLADKK LRQIESLGIS HYPICIAKTQ YSFSSDPKAY 500
    GVAKDFELKV RDVIINNGAE MIVVVMGEIM RMPGLPKEPQ ARKIDIVDGM 550
    IEGLS 555
    Length:555
    Mass (Da):60,156
    Last modified:July 24, 2007 - v1
    Checksum:iF8AEF9F9C702CF8D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000140 Genomic DNA. Translation: ABR42780.1.
    RefSeqiYP_001302402.1. NC_009615.1.

    Genome annotation databases

    EnsemblBacteriaiABR42780; ABR42780; BDI_1014.
    GeneIDi5306167.
    KEGGipdi:BDI_1014.
    PATRICi22845184. VBIParDis29947_0999.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000140 Genomic DNA. Translation: ABR42780.1 .
    RefSeqi YP_001302402.1. NC_009615.1.

    3D structure databases

    ProteinModelPortali A6LAR6.
    SMRi A6LAR6. Positions 4-553.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 435591.BDI_1014.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR42780 ; ABR42780 ; BDI_1014 .
    GeneIDi 5306167.
    KEGGi pdi:BDI_1014.
    PATRICi 22845184. VBIParDis29947_0999.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci PDIS435591:GCNH-1012-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8503 / DSM 20701 / NCTC 11152.

    Entry informationi

    Entry nameiFTHS_PARD8
    AccessioniPrimary (citable) accession number: A6LAR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3