A6LAR6 (FTHS_PARD8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase
EC=6.3.4.3

Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS

Gene names

Name:	fhs
Ordered Locus Names:	BDI_1014

Organism

Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) [Complete proteome] [HAMAP]

Taxonomic identifier

435591 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Parabacteroides

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 555	555	Formate--tetrahydrofolate ligase HAMAP MF_01543		PRO_0000300533
Regions
	Nucleotide binding	64 – 71	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6LAR6 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: F8AEF9F9C702CF8D	FASTA	555	60,156
	10 20 30 40 50 60 MKSDIEIARE TDLRKIKEVA TTLGIPREEV QNYGRYIAKV PIHLIDKKQM DQHNLILVTA 70 80 90 100 110 120 ITPTKAGIGK TTVSIGLALG LNKIGKKAVV ALREPSLGPC FGMKGGAAGG GYAQVLPMEN 130 140 150 160 170 180 INLHFTGDFH AVTSAHNMIT ALLDNYIYQT RNTCEGLKEI KWKRVLDVND RSLRNIVSGL 190 200 210 220 230 240 GGSANGVPTE TGFDITPASE IMAILCLATD IEDLKRRVGN ILLGYTNEDK PFTVNDLGIA 250 260 270 280 290 300 GAITVLLKDA LLPNLVQTTE NTPAFVHGGP FANIAHGCNS ISATQMALTY GDYVITEAGF 310 320 330 340 350 360 GADLGAEKFF NIKCRKAGLS PKLTVIVATA QSLKLHGGVP EKEIKEPNIE GLKNGFANLD 370 380 390 400 410 420 KHIENMKSFG QQVIVTFNRF ATDTDEEIAL VAEHCEEKGV GFAMNNVFAE GGEGGTELAR 430 440 450 460 470 480 LVVDTIENHP SAPLQYTYDL NDPIRTKVQK VAQKIYGASS IVYTTLADKK LRQIESLGIS 490 500 510 520 530 540 HYPICIAKTQ YSFSSDPKAY GVAKDFELKV RDVIINNGAE MIVVVMGEIM RMPGLPKEPQ 550 ARKIDIVDGM IEGLS

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8503 / DSM 20701 / NCTC 11152.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000140 Genomic DNA. Translation: ABR42780.1.
RefSeq	YP_001302402.1. NC_009615.1.
3D structure databases
ProteinModelPortal	A6LAR6.
SMR	A6LAR6. Positions 4-553.
ModBase	Search...
Protein-protein interaction databases
STRING	A6LAR6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5306167.
GenomeReviews	Gene locus BDI_1014 in contig CP000140_GR.
KEGG	pdi:BDI_1014.
PATRIC	22845184. VBIParDis29947_0999.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
HOGENOM	HBG677721.
OMA	EIMAVLC.
ProtClustDB	PRK13505.
Enzyme and pathway databases
BioCyc	PDIS435591:BDI_1014-MONOMER.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FTHS_PARD8

Accession

Primary (citable) accession number: A6LAR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program