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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathway: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPDIS435591:GCNH-1012-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:BDI_1014
OrganismiParabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)
Taxonomic identifieri435591 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeParabacteroides
ProteomesiUP000000566 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_0000300533Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi435591.BDI_1014.

Structurei

3D structure databases

ProteinModelPortaliA6LAR6.
SMRiA6LAR6. Positions 4-553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6LAR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSDIEIARE TDLRKIKEVA TTLGIPREEV QNYGRYIAKV PIHLIDKKQM
60 70 80 90 100
DQHNLILVTA ITPTKAGIGK TTVSIGLALG LNKIGKKAVV ALREPSLGPC
110 120 130 140 150
FGMKGGAAGG GYAQVLPMEN INLHFTGDFH AVTSAHNMIT ALLDNYIYQT
160 170 180 190 200
RNTCEGLKEI KWKRVLDVND RSLRNIVSGL GGSANGVPTE TGFDITPASE
210 220 230 240 250
IMAILCLATD IEDLKRRVGN ILLGYTNEDK PFTVNDLGIA GAITVLLKDA
260 270 280 290 300
LLPNLVQTTE NTPAFVHGGP FANIAHGCNS ISATQMALTY GDYVITEAGF
310 320 330 340 350
GADLGAEKFF NIKCRKAGLS PKLTVIVATA QSLKLHGGVP EKEIKEPNIE
360 370 380 390 400
GLKNGFANLD KHIENMKSFG QQVIVTFNRF ATDTDEEIAL VAEHCEEKGV
410 420 430 440 450
GFAMNNVFAE GGEGGTELAR LVVDTIENHP SAPLQYTYDL NDPIRTKVQK
460 470 480 490 500
VAQKIYGASS IVYTTLADKK LRQIESLGIS HYPICIAKTQ YSFSSDPKAY
510 520 530 540 550
GVAKDFELKV RDVIINNGAE MIVVVMGEIM RMPGLPKEPQ ARKIDIVDGM

IEGLS
Length:555
Mass (Da):60,156
Last modified:July 24, 2007 - v1
Checksum:iF8AEF9F9C702CF8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000140 Genomic DNA. Translation: ABR42780.1.
RefSeqiWP_005857104.1. NC_009615.1.
YP_001302402.1. NC_009615.1.

Genome annotation databases

EnsemblBacteriaiABR42780; ABR42780; BDI_1014.
GeneIDi5306167.
KEGGipdi:BDI_1014.
PATRICi22845184. VBIParDis29947_0999.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000140 Genomic DNA. Translation: ABR42780.1.
RefSeqiWP_005857104.1. NC_009615.1.
YP_001302402.1. NC_009615.1.

3D structure databases

ProteinModelPortaliA6LAR6.
SMRiA6LAR6. Positions 4-553.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi435591.BDI_1014.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR42780; ABR42780; BDI_1014.
GeneIDi5306167.
KEGGipdi:BDI_1014.
PATRICi22845184. VBIParDis29947_0999.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciPDIS435591:GCNH-1012-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8503 / DSM 20701 / NCTC 11152.

Entry informationi

Entry nameiFTHS_PARD8
AccessioniPrimary (citable) accession number: A6LAR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 24, 2007
Last modified: May 27, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.