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A6LAR6

- FTHS_PARD8

UniProt

A6LAR6 - FTHS_PARD8

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, BDI_1014
Organism
Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 718ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPDIS435591:GCNH-1012-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:BDI_1014
OrganismiParabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)
Taxonomic identifieri435591 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeParabacteroides
ProteomesiUP000000566: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000300533Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi435591.BDI_1014.

Structurei

3D structure databases

ProteinModelPortaliA6LAR6.
SMRiA6LAR6. Positions 4-553.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6LAR6-1 [UniParc]FASTAAdd to Basket

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MKSDIEIARE TDLRKIKEVA TTLGIPREEV QNYGRYIAKV PIHLIDKKQM    50
DQHNLILVTA ITPTKAGIGK TTVSIGLALG LNKIGKKAVV ALREPSLGPC 100
FGMKGGAAGG GYAQVLPMEN INLHFTGDFH AVTSAHNMIT ALLDNYIYQT 150
RNTCEGLKEI KWKRVLDVND RSLRNIVSGL GGSANGVPTE TGFDITPASE 200
IMAILCLATD IEDLKRRVGN ILLGYTNEDK PFTVNDLGIA GAITVLLKDA 250
LLPNLVQTTE NTPAFVHGGP FANIAHGCNS ISATQMALTY GDYVITEAGF 300
GADLGAEKFF NIKCRKAGLS PKLTVIVATA QSLKLHGGVP EKEIKEPNIE 350
GLKNGFANLD KHIENMKSFG QQVIVTFNRF ATDTDEEIAL VAEHCEEKGV 400
GFAMNNVFAE GGEGGTELAR LVVDTIENHP SAPLQYTYDL NDPIRTKVQK 450
VAQKIYGASS IVYTTLADKK LRQIESLGIS HYPICIAKTQ YSFSSDPKAY 500
GVAKDFELKV RDVIINNGAE MIVVVMGEIM RMPGLPKEPQ ARKIDIVDGM 550
IEGLS 555
Length:555
Mass (Da):60,156
Last modified:July 24, 2007 - v1
Checksum:iF8AEF9F9C702CF8D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000140 Genomic DNA. Translation: ABR42780.1.
RefSeqiYP_001302402.1. NC_009615.1.

Genome annotation databases

EnsemblBacteriaiABR42780; ABR42780; BDI_1014.
GeneIDi5306167.
KEGGipdi:BDI_1014.
PATRICi22845184. VBIParDis29947_0999.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000140 Genomic DNA. Translation: ABR42780.1 .
RefSeqi YP_001302402.1. NC_009615.1.

3D structure databases

ProteinModelPortali A6LAR6.
SMRi A6LAR6. Positions 4-553.
ModBasei Search...

Protein-protein interaction databases

STRINGi 435591.BDI_1014.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABR42780 ; ABR42780 ; BDI_1014 .
GeneIDi 5306167.
KEGGi pdi:BDI_1014.
PATRICi 22845184. VBIParDis29947_0999.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci PDIS435591:GCNH-1012-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8503 / DSM 20701 / NCTC 11152.

Entry informationi

Entry nameiFTHS_PARD8
AccessioniPrimary (citable) accession number: A6LAR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 24, 2007
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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