A6L8U3 (DAPF_PARD8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Diaminopimelate epimerase
Short name=DAP epimerase
EC=5.1.1.7

Gene names

Name:	dapF
Ordered Locus Names:	BDI_0322

Organism

Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) [Complete proteome] [HAMAP]

Taxonomic identifier

435591 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Parabacteroides

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate. HAMAP MF_00197
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1. HAMAP MF_00197
Subcellular location	Cytoplasm By similarity HAMAP MF_00197.
Sequence similarities	Belongs to the diaminopimelate epimerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lysine biosynthetic process via diaminopimelate Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	diaminopimelate epimerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Diaminopimelate epimerase HAMAP MF_00197		PRO_1000011922
Sites
	Active site	75	1	By similarity
	Active site	212	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6L8U3 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 5D9FC2F04DDA055F	FASTA	269	29,082
	10 20 30 40 50 60 MTKSIRFTKM HGAGNDYIYV NTMAYPIDNP EELSIAWSKP HTGIGSDGLV LIGSSDIADF 70 80 90 100 110 120 SMHIYNADGS EAMMCGNASR CIGKYVYEAG LTQKNKVTLE TLSGIKELQL KIEREEVTEV 130 140 150 160 170 180 TVDMGMPAVG EMALEVEAGG EIYTGTVISM GNPHLVIFVD EMDQVGLASV GPLLECLPLF 190 200 210 220 230 240 PDRTNVEFVQ VLKPDEVRMR VWERGSGITQ ACGTGACATA VAGVVRGKTK RKTKVIMDGG 250 260 PLTIEWDERS GKVFMTGGAV NVFEGFIKV

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8503 / DSM 20701 / NCTC 11152.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000140 Genomic DNA. Translation: ABR42107.1.
RefSeq	YP_001301729.1. NC_009615.1.
3D structure databases
ProteinModelPortal	A6L8U3.
ModBase	Search...
Protein-protein interaction databases
STRING	A6L8U3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5305477.
GenomeReviews	Gene locus BDI_0322 in contig CP000140_GR.
KEGG	pdi:BDI_0322.
PATRIC	22843794. VBIParDis29947_0318.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0253.
HOGENOM	HBG399442.
OMA	FMTGPAT.
ProtClustDB	PRK00450.
Enzyme and pathway databases
BioCyc	PDIS435591:BDI_0322-MONOMER.
Family and domain databases
HAMAP	MF_00197. DAP_epimerase. [Tree]
InterPro	IPR018510. DAP_epimerase_AS. IPR001653. DAP_epimerase_DapF. [Graphical view]
KO	K01778.
Pfam	PF01678. DAP_epimerase. 2 hits. [Graphical view]
TIGRFAMs	TIGR00652. DapF. 1 hit.
PROSITE	PS01326. DAP_EPIMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPF_PARD8

Accession

Primary (citable) accession number: A6L8U3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program