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A6L8U3

- DAPF_PARD8

UniProt

A6L8U3 - DAPF_PARD8

Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei15 – 151SubstrateUniRule annotation
    Binding sitei48 – 481SubstrateUniRule annotation
    Binding sitei66 – 661SubstrateUniRule annotation
    Active sitei75 – 751Proton donor/acceptorUniRule annotation
    Binding sitei152 – 1521SubstrateUniRule annotation
    Sitei154 – 1541Important for catalytic activityUniRule annotation
    Binding sitei185 – 1851SubstrateUniRule annotation
    Sitei203 – 2031Important for catalytic activityUniRule annotation
    Active sitei212 – 2121Proton donor/acceptorUniRule annotation

    GO - Molecular functioni

    1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Enzyme and pathway databases

    BioCyciPDIS435591:GCNH-322-MONOMER.
    UniPathwayiUPA00034; UER00025.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
    Short name:
    DAP epimeraseUniRule annotation
    Gene namesi
    Name:dapFUniRule annotation
    Ordered Locus Names:BDI_0322
    OrganismiParabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)
    Taxonomic identifieri435591 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeParabacteroides
    ProteomesiUP000000566: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Diaminopimelate epimerasePRO_1000011922Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi75 ↔ 212

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi435591.BDI_0322.

    Structurei

    3D structure databases

    ProteinModelPortaliA6L8U3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni75 – 773Substrate bindingUniRule annotation
    Regioni203 – 2042Substrate bindingUniRule annotation
    Regioni213 – 2142Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the diaminopimelate epimerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0253.
    HOGENOMiHOG000220466.
    KOiK01778.
    OMAiLIVEPPY.
    OrthoDBiEOG6ND0M5.

    Family and domain databases

    HAMAPiMF_00197. DAP_epimerase.
    InterProiIPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view]
    PANTHERiPTHR31689. PTHR31689. 1 hit.
    PfamiPF01678. DAP_epimerase. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00652. DapF. 1 hit.
    PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6L8U3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTKSIRFTKM HGAGNDYIYV NTMAYPIDNP EELSIAWSKP HTGIGSDGLV    50
    LIGSSDIADF SMHIYNADGS EAMMCGNASR CIGKYVYEAG LTQKNKVTLE 100
    TLSGIKELQL KIEREEVTEV TVDMGMPAVG EMALEVEAGG EIYTGTVISM 150
    GNPHLVIFVD EMDQVGLASV GPLLECLPLF PDRTNVEFVQ VLKPDEVRMR 200
    VWERGSGITQ ACGTGACATA VAGVVRGKTK RKTKVIMDGG PLTIEWDERS 250
    GKVFMTGGAV NVFEGFIKV 269
    Length:269
    Mass (Da):29,082
    Last modified:July 24, 2007 - v1
    Checksum:i5D9FC2F04DDA055F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000140 Genomic DNA. Translation: ABR42107.1.
    RefSeqiYP_001301729.1. NC_009615.1.

    Genome annotation databases

    EnsemblBacteriaiABR42107; ABR42107; BDI_0322.
    GeneIDi5305477.
    KEGGipdi:BDI_0322.
    PATRICi22843794. VBIParDis29947_0318.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000140 Genomic DNA. Translation: ABR42107.1 .
    RefSeqi YP_001301729.1. NC_009615.1.

    3D structure databases

    ProteinModelPortali A6L8U3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 435591.BDI_0322.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR42107 ; ABR42107 ; BDI_0322 .
    GeneIDi 5305477.
    KEGGi pdi:BDI_0322.
    PATRICi 22843794. VBIParDis29947_0318.

    Phylogenomic databases

    eggNOGi COG0253.
    HOGENOMi HOG000220466.
    KOi K01778.
    OMAi LIVEPPY.
    OrthoDBi EOG6ND0M5.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00025 .
    BioCyci PDIS435591:GCNH-322-MONOMER.

    Family and domain databases

    HAMAPi MF_00197. DAP_epimerase.
    InterProi IPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view ]
    PANTHERi PTHR31689. PTHR31689. 1 hit.
    Pfami PF01678. DAP_epimerase. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00652. DapF. 1 hit.
    PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8503 / DSM 20701 / NCTC 11152.

    Entry informationi

    Entry nameiDAPF_PARD8
    AccessioniPrimary (citable) accession number: A6L8U3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3