A6L8C4 (G6PI_PARD8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	BDI_0148

Organism

Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) [Complete proteome] [HAMAP]

Taxonomic identifier

435591 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Parabacteroides

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 447	447	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000013994
Sites
	Active site	289	1	Proton donor By similarity
	Active site	310	1	By similarity
	Active site	424	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6L8C4 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: C12A38CFDE3D7AD5	FASTA	447	48,734
	10 20 30 40 50 60 MKNISLNIDK ALGTVSKEQV YAQEAKAMEC IATLHNGNGA GNDFLGWLHL PSSITDAELA 70 80 90 100 110 120 DIENTANVLR SKCEVVVAIG IGGSYLGTKA VVEALNNSFD WLQNDRKNPV MLYAGHNIGE 130 140 150 160 170 180 DYLYELSEVL KGKQFGIINI SKSGTTTEPA LAFRILKKQL EDAVGKEEAK HRIVAITDAK 190 200 210 220 230 240 RGALRTLADQ EGYKTFIIPD NVGGRFSVLT PVGLLPIAVA GISIRDLVAG AVSMEKATDA 250 260 270 280 290 300 SVPFADNMAA IYAATRNELY KNGKKIEILA NFHPKLHYIA EWWKQLYGES EGKDGKGIFP 310 320 330 340 350 360 ASVDLTTDLH SMGQWIQDGE RTIFETVISV EATDHSVLVP TDEADLDGLN FLAGKHVDEV 370 380 390 400 410 420 NKMAELGTQL AHVDGGVPNI KVNMPEVSAF YIGQLFYFFE KACGISGYML GVNPFNQPGV 430 440 EAYKKNMFAL LNKPGYEKES EAIKARL

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8503 / DSM 20701 / NCTC 11152.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000140 Genomic DNA. Translation: ABR41938.1.
RefSeq	YP_001301560.1. NC_009615.1.
3D structure databases
ProteinModelPortal	A6L8C4.
SMR	A6L8C4. Positions 4-447.
ModBase	Search...
Protein-protein interaction databases
STRING	A6L8C4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5305239.
GenomeReviews	Gene locus BDI_0148 in contig CP000140_GR.
KEGG	pdi:BDI_0148.
PATRIC	22843428. VBIParDis29947_0140.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG615843.
OMA	DNLDGLN.
ProtClustDB	PRK14097.
Enzyme and pathway databases
BioCyc	PDIS435591:BDI_0148-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_PARD8

Accession

Primary (citable) accession number: A6L8C4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program