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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei289 – 2891Proton donorUniRule annotation
Active sitei310 – 3101UniRule annotation
Active sitei424 – 4241UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciPDIS435591:GCNH-148-MONOMER.
UniPathwayiUPA00109; UER00181.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:BDI_0148
OrganismiParabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)
Taxonomic identifieri435591 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPorphyromonadaceaeParabacteroides
ProteomesiUP000000566: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Glucose-6-phosphate isomerasePRO_1000013994Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi435591.BDI_0148.

Structurei

3D structure databases

ProteinModelPortaliA6L8C4.
SMRiA6L8C4. Positions 4-447.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OMAiSFIIPDD.
OrthoDBiEOG64R61J.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6L8C4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNISLNIDK ALGTVSKEQV YAQEAKAMEC IATLHNGNGA GNDFLGWLHL
60 70 80 90 100
PSSITDAELA DIENTANVLR SKCEVVVAIG IGGSYLGTKA VVEALNNSFD
110 120 130 140 150
WLQNDRKNPV MLYAGHNIGE DYLYELSEVL KGKQFGIINI SKSGTTTEPA
160 170 180 190 200
LAFRILKKQL EDAVGKEEAK HRIVAITDAK RGALRTLADQ EGYKTFIIPD
210 220 230 240 250
NVGGRFSVLT PVGLLPIAVA GISIRDLVAG AVSMEKATDA SVPFADNMAA
260 270 280 290 300
IYAATRNELY KNGKKIEILA NFHPKLHYIA EWWKQLYGES EGKDGKGIFP
310 320 330 340 350
ASVDLTTDLH SMGQWIQDGE RTIFETVISV EATDHSVLVP TDEADLDGLN
360 370 380 390 400
FLAGKHVDEV NKMAELGTQL AHVDGGVPNI KVNMPEVSAF YIGQLFYFFE
410 420 430 440
KACGISGYML GVNPFNQPGV EAYKKNMFAL LNKPGYEKES EAIKARL
Length:447
Mass (Da):48,734
Last modified:July 24, 2007 - v1
Checksum:iC12A38CFDE3D7AD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000140 Genomic DNA. Translation: ABR41938.1.
RefSeqiYP_001301560.1. NC_009615.1.

Genome annotation databases

EnsemblBacteriaiABR41938; ABR41938; BDI_0148.
GeneIDi5305239.
KEGGipdi:BDI_0148.
PATRICi22843428. VBIParDis29947_0140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000140 Genomic DNA. Translation: ABR41938.1.
RefSeqiYP_001301560.1. NC_009615.1.

3D structure databases

ProteinModelPortaliA6L8C4.
SMRiA6L8C4. Positions 4-447.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi435591.BDI_0148.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR41938; ABR41938; BDI_0148.
GeneIDi5305239.
KEGGipdi:BDI_0148.
PATRICi22843428. VBIParDis29947_0140.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000100403.
KOiK01810.
OMAiSFIIPDD.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
UPA00138.
BioCyciPDIS435591:GCNH-148-MONOMER.

Family and domain databases

HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8503 / DSM 20701 / NCTC 11152.

Entry informationi

Entry nameiG6PI_PARD8
AccessioniPrimary (citable) accession number: A6L8C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: January 7, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.