Cytochrome c-552 precursor - Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152)

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Reviewed, UniProtKB/Swiss-Prot A6L890 (NRFA_PARD8)

Last modified June 16, 2009. Version 17. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Cytochrome c-552
    EC=1.7.2.2
Alternative name(s):
    Ammonia-forming cytochrome c nitrite reductase
      Short name=Cytochrome c nitrite reductase

Gene names

Name:	nrfA
Ordered Locus Names:	BDI_0109

Organism

Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / NCTC 11152) [Complete proteome] [HAMAP]

Taxonomic identifier

435591 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Porphyromonadaceae › Parabacteroides

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Protein attributes

Sequence length	494 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Plays a role in nitrite reduction By similarity.
Catalytic activity	NH₃ + 2 H₂O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H⁺. HAMAP MF_01182
Cofactor	Binds 1 calcium ion per monomer By similarity. Binds 5 heme groups covalently per monomer By similarity.
Pathway	Nitrogen metabolism; nitrate reduction (assimilation). HAMAP MF_01182
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the cytochrome c-552 family.

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Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Periplasm
Domain	Repeat Signal
Ligand	Calcium Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW nitrogen compound metabolic process Inferred from electronic annotation. Source: HAMAP transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW nitrite reductase (cytochrome, ammonia-forming) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 31

Potential

Chain

32 – 494

463

Cytochrome c-552 HAMAP MF_01182

PRO_1000065804

Sites

Metal binding

116

Iron (heme 3 axial ligand) By similarity

Metal binding

148

Iron (heme 1 axial ligand) By similarity

Metal binding

186

Iron (heme 2 axial ligand) By similarity

Metal binding

228

Iron (heme 3 axial ligand) By similarity

Metal binding

230

Calcium By similarity

Metal binding

231

Calcium; via carbonyl oxygen By similarity

Metal binding

276

Calcium; via carbonyl oxygen By similarity

Metal binding

278

Calcium By similarity

Metal binding

290

Iron (heme 5 axial ligand) By similarity

Metal binding

301

Iron (heme 4 axial ligand) By similarity

Metal binding

315

Iron (heme 2 axial ligand) By similarity

Metal binding

332

Iron (heme 5 axial ligand) By similarity

Metal binding

407

Iron (heme 4 axial ligand) By similarity

Binding site

144

Heme 1 (covalent) By similarity

Binding site

147

Heme 1 (covalent) By similarity

Binding site

182

Heme 2 (covalent) By similarity

Binding site

185

Heme 2 (covalent) By similarity

Binding site

224

Heme 3 (covalent) By similarity

Binding site

227

Heme 3 (covalent) By similarity

Binding site

231

Substrate By similarity

Binding site

279

Substrate By similarity

Binding site

297

Heme 4 (covalent) By similarity

Binding site

300

Heme 4 (covalent) By similarity

Binding site

328

Heme 5 (covalent) By similarity

Binding site

331

Heme 5 (covalent) By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

A6L890-1 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 58ECCCF0E077EF53
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FASTA

494

56,145

        10         20         30         40         50         60 
MEKKLKSWQG WLLFGGTMVV VFVLGMIAAS VNERHAEVTS VMNNKKTEIT GIEARNDKFE 

        70         80         90        100        110        120 
SNYPREYQTW EATADTSFKS LYNGNQAVDV LEARPEMVIL WAGYAFSKDY STPRGHMHAI 

       130        140        150        160        170        180 
EDMRNTLRVG APMTENEGPQ PATCWTCKSP DVPRMMQAMG VDNFYKGKWA SLGKEIVNPI 

       190        200        210        220        230        240 
GCADCHEPEN MNLHISRPAL IEAFQRQGKD ITKATQQEMR SLVCAQCHVE YYFKGDGKYL 

       250        260        270        280        290        300 
TFPWDKGSTV EDMEAYYDEA GFADYTHKLS RAPILKAQHP DYEISQMGIH AQRGVSCADC 

       310        320        330        340        350        360 
HMPYKSEGGV KYSDHHIQSP LAMIDRTCQV CHRESEETLR NNVYERQNKA NEMRNRLETE 

       370        380        390        400        410        420 
LAKAHVEAKF AWDKGATEDQ MKDVLKLIRQ AQWRWDFGVA SHGGAFHAPQ EIQRILGNGL 

       430        440        450        460        470        480 
DKAMQARLAT AKVLAKLGYT DDVPMPDFST KEKAQQYIGL DMAAERTAKE KFLNTIVPQW 

       490 
MKEAQENNRL AKNI

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References

[1]

"Evolution of symbiotic bacteria in the distal human intestine."
Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I.
PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases
	CP000140 Genomic DNA. Translation: ABR41904.1.
RefSeq	YP_001301526.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5305200.
GenomeReviews	Gene locus BDI_0109 in contig CP000140_GR.
KEGG	pdi:BDI_0109.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A6L890. HKESGAP.
Family and domain databases
HAMAP	MF_01182. [Tree]
InterPro	IPR003321. Cyt_c552. IPR011031. Multihaem_cyt. [Graphical view]
Pfam	PF02335. Cytochrom_C552. 1 hit. [Graphical view]
PIRSF	PIRSF000243. Cyt_c552. 1 hit.
PROSITE	PS51008. MULTIHEME_CYTC. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

NRFA_PARD8

Accession

Primary (citable) accession number: A6L890

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 24, 2007
Last modified:	June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents