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A6L7T5 (UNG_BACV8) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uracil-DNA glycosylase
Short name=UDG
EC=3.2.2.27
Gene names
Name:ung
Ordered Locus Names:BVU_4148
OrganismBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]
Taxonomic identifier435590 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides ›

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine By similarity. HAMAP-Rule MF_00148

Catalytic activity

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil. HAMAP-Rule MF_00148

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00148.

Sequence similarities

Belongs to the uracil-DNA glycosylase family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   Cellular componentCytoplasm
   Molecular functionGlycosidase
Hydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processbase-excision repair

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionuracil DNA N-glycosylase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Uracil-DNA glycosylase HAMAP-Rule MF_00148
PRO_1000009867

Sites

Active site651Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
A6L7T5 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 9A9134779AE295B0

FASTA22024,956
        10         20         30         40         50         60 
MNVQIEESWK QHLAPEFEKD YFIRLTEFVR SEYQTATIYP PGRFIFNAFN LCPFDKVKVV 

        70         80         90        100        110        120 
IIGQDPYHGP GQAHGLCFSV NDGVPFPPSL QNIFKEIQSD LGAPIPTSGN LTRWANQGVL 

       130        140        150        160        170        180 
LLNATLTVRA HQAGSHQRRG WEEFTDAAIR VLAEQRENIV FILWGSYAQK KGAFIDRNKH 

       190        200        210        220 
LVLASAHPSP LSAYNGFFGN KHFSRTNEYL QAHGQTPIEW

« Hide

References

[1]"Evolution of symbiotic bacteria in the distal human intestine."
Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I.
PLoS Biol. 5:1574-1586(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000139 Genomic DNA. Translation: ABR41749.1.
RefSeqYP_001301371.1. NC_009614.1.

3D structure databases

ProteinModelPortalA6L7T5.
SMRA6L7T5. Positions 7-220.
ModBaseSearch...

Protein-protein interaction databases

STRING435590.BVU_4148.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR41749; ABR41749; BVU_4148.
GeneID5305107.
KEGGbvu:BVU_4148.
PATRIC21073396. VBIBacVul85104_4258.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0692.
HOGENOMHOG000229528.
KOK03648.
OMAAGKEIYP.
ProtClustDBPRK05254.

Enzyme and pathway databases

BioCycBVUL435590:GH96-4138-MONOMER.

Family and domain databases

Gene3D3.40.470.10. 1 hit.
HAMAPMF_00148. UDG.
InterProIPR018085. Ura-DNA_Glyclase_AS.
IPR002043. Ura_DNA_glycsylse.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERPTHR11264. PTHR11264. 1 hit.
PfamPF03167. UDG. 1 hit.
[Graphical view]
SMARTSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMSSF52141. UDNA_glycsylseSF. 1 hit.
TIGRFAMsTIGR00628. ung. 1 hit.
PROSITEPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUNG_BACV8
AccessionPrimary (citable) accession number: A6L7T5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: May 29, 2013
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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