ID   A6L7T1_PHOV8            Unreviewed;       546 AA.
AC   A6L7T1;
DT   24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=Glycoside hydrolase family 33, candidate sialidase {ECO:0000313|EMBL:ABR41745.1};
GN   OrderedLocusNames=BVU_4143 {ECO:0000313|EMBL:ABR41745.1};
OS   Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 /
OS   NBRC 14291 / NCTC 11154) (Bacteroides vulgatus).
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Phocaeicola.
OX   NCBI_TaxID=435590 {ECO:0000313|EMBL:ABR41745.1, ECO:0000313|Proteomes:UP000002861};
RN   [1] {ECO:0000313|EMBL:ABR41745.1, ECO:0000313|Proteomes:UP000002861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 /
RC   NCTC 11154 {ECO:0000313|Proteomes:UP000002861};
RX   PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA   Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA   Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA   Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA   Knight R.D., Gordon J.I.;
RT   "Evolution of symbiotic bacteria in the distal human intestine.";
RL   PLoS Biol. 5:1574-1586(2007).
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DR   EMBL; CP000139; ABR41745.1; -; Genomic_DNA.
DR   RefSeq; WP_005851277.1; NZ_JANSWM010000087.1.
DR   AlphaFoldDB; A6L7T1; -.
DR   SMR; A6L7T1; -.
DR   STRING; 435590.BVU_4143; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   PaxDb; 435590-BVU_4143; -.
DR   GeneID; 69842420; -.
DR   KEGG; bvu:BVU_4143; -.
DR   eggNOG; COG4409; Bacteria.
DR   HOGENOM; CLU_024620_0_0_10; -.
DR   BioCyc; BVUL435590:G1G59-4281-MONOMER; -.
DR   Proteomes; UP000002861; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.40.1290; -; 1.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR029456; Sialidase_N.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF19; SIALIDASE; 1.
DR   Pfam; PF13859; BNR_3; 1.
DR   Pfam; PF14873; BNR_assoc_N; 1.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:ABR41745.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002861};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..546
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002696648"
FT   DOMAIN          24..173
FT                   /note="Sialidase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14873"
FT   DOMAIN          206..485
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13859"
SQ   SEQUENCE   546 AA;  60312 MW;  3CC452B2DF4CB3F0 CRC64;
     MRNPSLLLLI VVFILAPFKL SAAADTVVVR ETRIPVLIER QDNELFHLRI EATQSQMLNE
     VKLDFGKDVN LNEIESVKLY YGGTESVERR GKTYFAPVDY ISNNTPGKTL AANTSYSVLK
     SEVKAPKREV VLKADQKLFP GVNYFWISLQ MKPVASILSK VSAEVVEAKI DGQVAPLKIA
     RKADTHYMGI GVRHAGDDGA AAYRIPGLAT SNKGTLLGVY DVRYNNSADL QEYVEIGLSR
     STDGGQTWEK MRIPMAFGEY DGLPKAQNGV GDPAILVDKK TGTIWIVAAW THGMGNGRAW
     WNSQTGMDRN HTAQLMMVKS DDDGKTWSEP MNITEQVKDP SWYFLLQGPG RGISMEDGTL
     VFASQYIGND RIPNAGIIYS KDHGKTWNIS TLARTNTTES QVAEVEPGVL MLNMRDNRGG
     SRAVSTTTDL GKTWKEHESS RTALQEPVCM ASLISVKAKE NVLGKDILLF SNPNDAKNRH
     SITIKASLDG GVTWLPENQL LLDAGWGWGY SCLTMIDKET VGILYESSVA HMTFQAIKLK
     DIIKTK
//