A6L7P7 (G6PI_BACV8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	BVU_4109

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 447	447	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000013941
Sites
	Active site	289	1	Proton donor By similarity
	Active site	310	1	By similarity
	Active site	424	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6L7P7 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: CDC3ED28BCA73119	FASTA	447	49,048
	10 20 30 40 50 60 MKNISLNIDK VAGFVSKETI AAYEPQVKAC METLENGTGK GNDFLGWLHL PSSITAEHLA 70 80 90 100 110 120 DLKATAQVLR DNCEVVVVAG IGGSYLGARA VIEALSNSFQ WLKAKQDGPV IVFAGHNISE 130 140 150 160 170 180 DYLFELTAYL KDKKFGVINI SKSGTTTETA LAFRLLKKQC EDQLGKEMAK KVIVAVTDAK 190 200 210 220 230 240 KGAARVTADK EGYQTFIIPD NVGGRFSVLT PVGLLPIAVA GFDIEKLVEG ARTMETICGP 250 260 270 280 290 300 ATPFAENPAA VYAATRNELY KDGKKIEILV NFNPKLHYMN EWWKQLYGES EGKDGKGIYP 310 320 330 340 350 360 SAVDFSTDLH SMGQWIQEGE RTIFETVISI ENPEHTLQVP SDSENLDGLN FLAGKRVDEV 370 380 390 400 410 420 NKMAELGTQL AHVDGGVPNM RLIVPELNEY YLGEIIYFFE KACGISGYLL GVNPFNQPGV 430 440 EAYKKNMFAL LNKPGYEEES KAIQARL

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000139 Genomic DNA. Translation: ABR41711.1.
RefSeq	YP_001301333.1. NC_009614.1.
3D structure databases
ProteinModelPortal	A6L7P7.
SMR	A6L7P7. Positions 4-447.
ModBase	Search...
Protein-protein interaction databases
STRING	A6L7P7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5305068.
GenomeReviews	Gene locus BVU_4109 in contig CP000139_GR.
KEGG	bvu:BVU_4109.
NMPDR	fig|435590.6.peg.3821.
PATRIC	21073316. VBIBacVul85104_4219.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HBG615843.
OMA	DNLDGLN.
ProtClustDB	PRK14097.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_BACV8

Accession

Primary (citable) accession number: A6L7P7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program