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A6L7E5

- DAPF_BACV8

UniProt

A6L7E5 - DAPF_BACV8

Protein

Diaminopimelate epimerase

Gene

dapF

Organism
Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei15 – 151SubstrateUniRule annotation
    Binding sitei48 – 481SubstrateUniRule annotation
    Binding sitei66 – 661SubstrateUniRule annotation
    Active sitei75 – 751Proton donor/acceptorUniRule annotation
    Binding sitei163 – 1631SubstrateUniRule annotation
    Sitei165 – 1651Important for catalytic activityUniRule annotation
    Binding sitei196 – 1961SubstrateUniRule annotation
    Sitei214 – 2141Important for catalytic activityUniRule annotation
    Active sitei223 – 2231Proton donor/acceptorUniRule annotation

    GO - Molecular functioni

    1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Enzyme and pathway databases

    BioCyciBVUL435590:GH96-3996-MONOMER.
    UniPathwayiUPA00034; UER00025.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diaminopimelate epimeraseUniRule annotation (EC:5.1.1.7UniRule annotation)
    Short name:
    DAP epimeraseUniRule annotation
    Gene namesi
    Name:dapFUniRule annotation
    Ordered Locus Names:BVU_4006
    OrganismiBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154)
    Taxonomic identifieri435590 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
    ProteomesiUP000002861: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 280280Diaminopimelate epimerasePRO_1000011844Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi75 ↔ 223

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi435590.BVU_4006.

    Structurei

    3D structure databases

    ProteinModelPortaliA6L7E5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni75 – 773Substrate bindingUniRule annotation
    Regioni214 – 2152Substrate bindingUniRule annotation
    Regioni224 – 2252Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the diaminopimelate epimerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0253.
    HOGENOMiHOG000220466.
    KOiK01778.
    OMAiLIVEPPY.
    OrthoDBiEOG6ND0M5.

    Family and domain databases

    HAMAPiMF_00197. DAP_epimerase.
    InterProiIPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view]
    PANTHERiPTHR31689. PTHR31689. 1 hit.
    PfamiPF01678. DAP_epimerase. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR00652. DapF. 1 hit.
    PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6L7E5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATTIKFTKM QGTGNDYIYV NTLSSPLQDP IKAARKWSTY HTGIGADGLV    50
    LIGASEKADF SMRIFNADGS EAMMCGNASR CIGKYVYEKG LTDKEVITLE 100
    TLSGIKILKL HTGNGVVKDV TVDMGTPLLS NPGQIATKTG GMLAETIPAD 150
    GKEYKGTFVC MGNPHVVIFV DDIKEVDLPA VGPKLENHPL FPERTNVEFV 200
    EILPDQSLRM RVWERGSGIT MACGTGACAT AVAAVLNHKA GRKSWVRMDG 250
    GDLHIHWNEK DGHVYMTGPA GKVFEGEIEM 280
    Length:280
    Mass (Da):30,295
    Last modified:July 24, 2007 - v1
    Checksum:i250E887C76250C39
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000139 Genomic DNA. Translation: ABR41609.1.
    RefSeqiYP_001301231.1. NC_009614.1.

    Genome annotation databases

    EnsemblBacteriaiABR41609; ABR41609; BVU_4006.
    GeneIDi5304965.
    KEGGibvu:BVU_4006.
    PATRICi21073106. VBIBacVul85104_4115.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000139 Genomic DNA. Translation: ABR41609.1 .
    RefSeqi YP_001301231.1. NC_009614.1.

    3D structure databases

    ProteinModelPortali A6L7E5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 435590.BVU_4006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABR41609 ; ABR41609 ; BVU_4006 .
    GeneIDi 5304965.
    KEGGi bvu:BVU_4006.
    PATRICi 21073106. VBIBacVul85104_4115.

    Phylogenomic databases

    eggNOGi COG0253.
    HOGENOMi HOG000220466.
    KOi K01778.
    OMAi LIVEPPY.
    OrthoDBi EOG6ND0M5.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00025 .
    BioCyci BVUL435590:GH96-3996-MONOMER.

    Family and domain databases

    HAMAPi MF_00197. DAP_epimerase.
    InterProi IPR018510. DAP_epimerase_AS.
    IPR001653. DAP_epimerase_DapF.
    [Graphical view ]
    PANTHERi PTHR31689. PTHR31689. 1 hit.
    Pfami PF01678. DAP_epimerase. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR00652. DapF. 1 hit.
    PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

    Entry informationi

    Entry nameiDAPF_BACV8
    AccessioniPrimary (citable) accession number: A6L7E5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3