A6L7E5 (DAPF_BACV8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Diaminopimelate epimerase
Short name=DAP epimerase
EC=5.1.1.7

Gene names

Name:	dapF
Ordered Locus Names:	BVU_4006

Organism

Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / NCTC 11154) [Complete proteome] [HAMAP]

Taxonomic identifier

435590 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate. HAMAP MF_00197
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1. HAMAP MF_00197
Subcellular location	Cytoplasm By similarity HAMAP MF_00197.
Sequence similarities	Belongs to the diaminopimelate epimerase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lysine biosynthetic process via diaminopimelate Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	diaminopimelate epimerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Diaminopimelate epimerase HAMAP MF_00197		PRO_1000011844
Sites
	Active site	75	1	By similarity
	Active site	223	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6L7E5 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 250E887C76250C39	FASTA	280	30,295
	10 20 30 40 50 60 MATTIKFTKM QGTGNDYIYV NTLSSPLQDP IKAARKWSTY HTGIGADGLV LIGASEKADF 70 80 90 100 110 120 SMRIFNADGS EAMMCGNASR CIGKYVYEKG LTDKEVITLE TLSGIKILKL HTGNGVVKDV 130 140 150 160 170 180 TVDMGTPLLS NPGQIATKTG GMLAETIPAD GKEYKGTFVC MGNPHVVIFV DDIKEVDLPA 190 200 210 220 230 240 VGPKLENHPL FPERTNVEFV EILPDQSLRM RVWERGSGIT MACGTGACAT AVAAVLNHKA 250 260 270 280 GRKSWVRMDG GDLHIHWNEK DGHVYMTGPA GKVFEGEIEM

References

[1]

"Evolution of symbiotic bacteria in the distal human intestine." Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C., Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H., Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K., Knight R.D., Gordon J.I. PLoS Biol. 5:1574-1586(2007) [PubMed: 17579514] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8482 / DSM 1447 / NCTC 11154.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000139 Genomic DNA. Translation: ABR41609.1.
RefSeq	YP_001301231.1. NC_009614.1.
3D structure databases
ProteinModelPortal	A6L7E5.
ModBase	Search...
Protein-protein interaction databases
STRING	A6L7E5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5304965.
GenomeReviews	Gene locus BVU_4006 in contig CP000139_GR.
KEGG	bvu:BVU_4006.
NMPDR	fig|435590.6.peg.3721.
PATRIC	21073106. VBIBacVul85104_4115.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0253.
HOGENOM	HBG399442.
OMA	AMARPAE.
ProtClustDB	PRK00450.
Family and domain databases
HAMAP	MF_00197. DAP_epimerase. [Tree]
InterPro	IPR018510. DAP_epimerase_AS. IPR001653. DAP_epimerase_DapF. [Graphical view]
KO	K01778.
Pfam	PF01678. DAP_epimerase. 2 hits. [Graphical view]
TIGRFAMs	TIGR00652. DapF. 1 hit.
PROSITE	PS01326. DAP_EPIMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPF_BACV8

Accession

Primary (citable) accession number: A6L7E5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program