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Protein

Xylose isomerase

Gene

xylA

Organism
Bacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei103UniRule annotation1
Active sitei106UniRule annotation1
Metal bindingi234Magnesium 1UniRule annotation1
Metal bindingi270Magnesium 1UniRule annotation1
Metal bindingi270Magnesium 2UniRule annotation1
Metal bindingi273Magnesium 2UniRule annotation1
Metal bindingi298Magnesium 1UniRule annotation1
Metal bindingi309Magnesium 2UniRule annotation1
Metal bindingi311Magnesium 2UniRule annotation1
Metal bindingi341Magnesium 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:BVU_3953
OrganismiBacteroides vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / NBRC 14291 / NCTC 11154)
Taxonomic identifieri435590 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesBacteroidaceaeBacteroides
Proteomesi
  • UP000002861 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000264301 – 438Xylose isomeraseAdd BLAST438

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi435590.BVU_3953.

Structurei

3D structure databases

ProteinModelPortaliA6L792.
SMRiA6L792.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6L792-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATKEYFPGI GKIKFEGKES KNPMAFRYYD AEKVINGKKM KDWLKFAMAW
60 70 80 90 100
WHTLCAEGGD QFGGGTKKFP WNGDADKVQA AKNKMDAGFE FMQKMGIEYY
110 120 130 140 150
CFHDVDLCEE ADTIEEYEAN LKEIVAYAKQ KQAETGIKLL WGTANVFGHA
160 170 180 190 200
RYMNGAATNP EFDVVARAAV QIKNAIDATI ELGGSNYVFW GGREGYMSLL
210 220 230 240 250
NTDQKREKEH LAQMLTIARD YARSKGFTGT FLIEPKPMEP TKHQYDVDTE
260 270 280 290 300
TVVGFLKTHG LDKDFKVNIE VNHATLAGHT FEHELAVAVD NGMLGSIDAN
310 320 330 340 350
RGDYQNGWDT DQFPIDNYEL TQAMMQIIRN GGLGNGGTNF DAKTRRNSTD
360 370 380 390 400
LEDIFIAHIA GMDAMARALE SAAALLNESP YCKMLSDRYA SFDSGKGKEF
410 420 430
EEGKLTLEDV VAYAKQNGEP KQVSGKQELY EAIVNMYC
Length:438
Mass (Da):49,036
Last modified:July 24, 2007 - v1
Checksum:iF1AC973EF3A2F230
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000139 Genomic DNA. Translation: ABR41556.1.
RefSeqiWP_005851486.1. NC_009614.1.

Genome annotation databases

EnsemblBacteriaiABR41556; ABR41556; BVU_3953.
GeneIDi5304912.
KEGGibvu:BVU_3953.
PATRICi21073000. VBIBacVul85104_4062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000139 Genomic DNA. Translation: ABR41556.1.
RefSeqiWP_005851486.1. NC_009614.1.

3D structure databases

ProteinModelPortaliA6L792.
SMRiA6L792.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi435590.BVU_3953.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR41556; ABR41556; BVU_3953.
GeneIDi5304912.
KEGGibvu:BVU_3953.
PATRICi21073000. VBIBacVul85104_4062.

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.
HOGENOMiHOG000252293.
KOiK01805.
OMAiHTFQHEL.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYLA_BACV8
AccessioniPrimary (citable) accession number: A6L792
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.