ID   A6L734_PHOV8            Unreviewed;       482 AA.
AC   A6L734;
DT   24-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   24-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   RecName: Full=Glutamate decarboxylase {ECO:0000256|ARBA:ARBA00012421, ECO:0000256|RuleBase:RU361171};
DE            EC=4.1.1.15 {ECO:0000256|ARBA:ARBA00012421, ECO:0000256|RuleBase:RU361171};
GN   OrderedLocusNames=BVU_3895 {ECO:0000313|EMBL:ABR41498.1};
OS   Phocaeicola vulgatus (strain ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 /
OS   NBRC 14291 / NCTC 11154) (Bacteroides vulgatus).
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Phocaeicola.
OX   NCBI_TaxID=435590 {ECO:0000313|EMBL:ABR41498.1, ECO:0000313|Proteomes:UP000002861};
RN   [1] {ECO:0000313|EMBL:ABR41498.1, ECO:0000313|Proteomes:UP000002861}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8482 / DSM 1447 / JCM 5826 / CCUG 4940 / NBRC 14291 /
RC   NCTC 11154 {ECO:0000313|Proteomes:UP000002861};
RX   PubMed=17579514; DOI=10.1371/journal.pbio.0050156;
RA   Xu J., Mahowald M.A., Ley R.E., Lozupone C.A., Hamady M., Martens E.C.,
RA   Henrissat B., Coutinho P.M., Minx P., Latreille P., Cordum H.,
RA   Van Brunt A., Kim K., Fulton R.S., Fulton L.A., Clifton S.W., Wilson R.K.,
RA   Knight R.D., Gordon J.I.;
RT   "Evolution of symbiotic bacteria in the distal human intestine.";
RL   PLoS Biol. 5:1574-1586(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-glutamate = 4-aminobutanoate + CO2;
CC         Xref=Rhea:RHEA:17785, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:59888; EC=4.1.1.15;
CC         Evidence={ECO:0000256|ARBA:ARBA00000018,
CC         ECO:0000256|RuleBase:RU361171};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR602129-50, ECO:0000256|RuleBase:RU000382};
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|RuleBase:RU000382}.
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DR   EMBL; CP000139; ABR41498.1; -; Genomic_DNA.
DR   RefSeq; WP_012055931.1; NC_009614.1.
DR   AlphaFoldDB; A6L734; -.
DR   STRING; 435590.BVU_3895; -.
DR   PaxDb; 435590-BVU_3895; -.
DR   KEGG; bvu:BVU_3895; -.
DR   PATRIC; fig|435590.9.peg.3999; -.
DR   eggNOG; COG0076; Bacteria.
DR   HOGENOM; CLU_019582_2_1_10; -.
DR   BioCyc; BVUL435590:G1G59-4031-MONOMER; -.
DR   Proteomes; UP000002861; Chromosome.
DR   GO; GO:0004351; F:glutamate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0006536; P:glutamate metabolic process; IEA:InterPro.
DR   CDD; cd06450; DOPA_deC_like; 1.
DR   Gene3D; 3.90.1150.160; -; 1.
DR   Gene3D; 4.10.280.50; -; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR010107; Glutamate_decarboxylase.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   NCBIfam; TIGR01788; Glu-decarb-GAD; 1.
DR   PANTHER; PTHR43321; GLUTAMATE DECARBOXYLASE; 1.
DR   PANTHER; PTHR43321:SF3; GLUTAMATE DECARBOXYLASE; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Decarboxylase {ECO:0000256|RuleBase:RU361171};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000382};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW   ECO:0000256|RuleBase:RU000382};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002861}.
FT   MOD_RES         276
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR602129-50"
SQ   SEQUENCE   482 AA;  54642 MW;  E31D4BB75B53CE7A CRC64;
     MKECNCDLRD GDAKTAVFGS NEMLQPAPVD TIPMEPTTPQ IAYQMVKDET FAQTQPRLNL
     ATFVTTYMDD YATKLMNEAI SINYIDETEY PRIAVMNAKC INIMANLWNS PEQAKWKTGA
     LAIGSSEACM LGGVAAWLRW KDKRKAQGKP TDKPNFVISS GFQVVWEKFA QLWQIEMRQV
     PLTLDKTTLD PEEALKMCDE NTICIVPIQG VTWTGLNDDV EALDKALDAY NAKTGYDIPI
     HVDAATGGFI LPFLNPDTKW DFRLKWVLSI STSGHKFGLV YPGLGWVVWK DKKYLPDAMS
     FSVNYLGANI TQVGLNFSRP AAQILGQYYQ FIRLGFQGYK AIQYNSMEIT KYIHSEIAKM
     APFVNYSDDV VNPLFIWYMK PEYAKNAKWT LYDLQAKLQQ SGWMVPAYTL PENIQNYVVM
     RVVVRQGFSR DMADMLLNDI KNAICEFEKL EYPTPTRIAQ DKNIAVKGTV FTHNAHSNAA
     KK
//